A5006680675- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Pharmacogenetics and Drug Metabolism
- Animal Genetics and Reproduction
- Advanced Proteomics Techniques and Applications
- Ubiquitin and proteasome pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Nuclear Structure and Function
- Cancer-related molecular mechanisms research
- Palliative Care and End-of-Life Issues
- Microtubule and mitosis dynamics
- Lipid metabolism and biosynthesis
- Schizophrenia research and treatment
- Ruminant Nutrition and Digestive Physiology
Nanjing Medical University
2016-2025
Nanjing Agricultural University
2022-2025
Suzhou Municipal Hospital
2020-2024
University of Iowa
2020-2024
Peking University
2014-2024
Peking University Third Hospital
2021-2024
University of Hong Kong - Shenzhen Hospital
2016-2024
University of Hong Kong
2016-2024
Research Center for Rural Economy
2024
Shandong Provincial Hospital
2023-2024
Background Gestational diabetes mellitus (GDM) is one type of that presents during pregnancy and significantly increases the risk a number adverse consequences for fetus mother. The microRNAs (miRNA) have recently been demonstrated to abundantly stably exist in serum be potentially disease-specific. However, no reported study investigates associations between miRNA GDM. Methodology/Principal Findings We systematically used TaqMan Low Density Array followed by individual quantitative reverse...
<h3>BACKGROUND/AIMS</h3> To evaluate prevalence, aetiology, prognosis, and associated neurological ophthalmological problems in children with cortical visual impairment (CVI). <h3>METHODS</h3> The records of 7200 outpatients seen the paediatric ophthalmology practice over past 15 years were reviewed order to compile data concerning CVI. In addition, authors devised applied a system for grading recovery assess prognosis. <h3>RESULTS</h3> CVI occurred 2.4% all patients examined. four most...
Abstract Cancer-testis ( CT ) genes represent the similarity between processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver in cancer. In this study, we integrate transcriptomics data from multiple databases systematically 876 new 19 cancer types. We explore relationship with testis-specific regulatory elements. propose extremely highly expressed (EECTGs) are potential drivers activated through epigenetic mechanisms....
N6-methyladenosine (m6A) is the most prevalent epigenetic modification of messenger RNA (mRNA) in higher eukaryotes; this mainly catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as key factor. Although m6A has been proven to play an essential role diverse biological processes, our knowledge Mettl3 still limited because mutations are lethal embryos both mammals and plants. In study, we knocked down microinjection its specific short interfering RNAs (siRNAs)...
Abstract Aims A mechanistic link between depression and risk of arrhythmias could be attributed to altered catecholamine metabolism in the heart. Monoamine oxidase-A (MAO-A), a key enzyme involved longstanding antidepressant target, is highly expressed myocardium. The present study aimed elucidate functional significance underlying mechanisms cardiac MAO-A arrhythmogenesis. Methods results Analysis TriNetX database revealed that depressed patients treated with MAO inhibitors had lower...
The mature mouse oocyte contains the full complement of maternal proteins required for fertilization, reprogramming, zygotic gene activation (ZGA), and early stages embryogenesis. However, due to limitations traditional proteomics strategies, only a few abundantly expressed have yet been identified. Our laboratory applied more effective strategy: one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (1D SDS-PAGE) reverse-phase liquid chromatography tandem mass...
Abstract Mammalian spermatozoa contain a complex population of mRNAs, some which have been demonstrated to be translated de novo by mitochondrial‐type ribosomes using D‐chloramphenicol (CP), specific inhibitor mitochondrial translation. However, little is known about the functions these mRNAs in mature sperm. In present study, differential proteomic approaches were applied study sperm protein profiles CP and 44 proteins identified with lower expression CP‐treated comparison capacitated...
Spermiogenesis is a unique process in mammals during which haploid round spermatids mature into spermatozoa the testis. Its successful completion necessary for fertilization and its malfunction an important cause of male infertility. Here, we report high-confidence identification 2116 proteins mouse germ cells undergoing spermiogenesis: 299 these were testis-specific 155 novel. Analysis showed many possibly functioning processes spermiogenesis. Of 84 annotated to be involved vesicle-related...
The regulation of chromatin structure in eukaryotic cells involves abundant architectural factors such as high mobility group B (HMGB) proteins.It is not understood how these control the interplay between genome accessibility and compaction.In vivo, HMO1 binds promoter coding regions most ribosomal RNA genes, facilitating transcription possibly stabilizing absence histones.To understand performs functions, we combine single molecule stretching atomic force microscopy (AFM).By HMO1-bound DNA,...
Scientific Report10 January 2017free access Source DataTransparent process The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition Ye Yang State Key Laboratory of Reproductive Medicine, Department Histology Embryology, Nanjing Medical University, Nanjing, China Reproduction, Obstetrics Gynecology Hospital Affiliated to Search more papers by this author Cheng Zhou Ying Wang Weixiao Liu Stem Cell Biology, Institute Zoology, the Chinese Academy...
Abstract The human zona pellucida (ZP) is a highly organized glycoprotein matrix that encircles oocytes and plays an essential role in successful reproduction. Previous studies have reported mutations ZP1, ZP2 ZP3 influence their functions result lack of ZP or abnormal empty follicle syndrome, which leads to female infertility. Here, we performed whole‐exome sequencing two probands with primary infertility whose lacked ZP, identified heterozygous mutation ZP1 (NM_207341:c.326G>A...
Entomopathogenic fungi represent a valuable natural resource with significant potential as biological agents for pest management. However, different species or strains of demonstrate varying effectiveness against specific targets. In this study, we assessed the impact two fungal strains, Beauveria bassiana KN801 and KN802, on rice planthoppers Ninaparvata lugens Sogatella furcifera, in combination insecticides. Our findings indicate that both B. can effectively infect nymphs adults N. S....
We characterized cellular and molecular mechanisms involved in spermatogenesis following short-term heat exposure of murine testis. For these studies, we utilized a proteomic approach with two-dimensional gel electrophoresis (2DE) analyses mass spectroscopic identification proteins altered expression mouse testes at different times after shock. established proteome reference map from 7-wk-old testis linked to federated database. used tools analyze quantitative variations the tissue over time...