A5045953890- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
- 14-3-3 protein interactions
- Cancer-related gene regulation
- Sodium Intake and Health
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Protein Kinase Regulation and GTPase Signaling
- Thyroid Disorders and Treatments
- Renal and related cancers
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Alcohol Consumption and Health Effects
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Acid Research Studies
- Signaling Pathways in Disease
- Acute Ischemic Stroke Management
- Cyclopropane Reaction Mechanisms
- Advanced NMR Techniques and Applications
- Microtubule and mitosis dynamics
- Cardiac electrophysiology and arrhythmias
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
University of California, Davis
2024
Nanjing Medical University
2019-2021
Suzhou Municipal Hospital
2020-2021
Liaoning Provincial People's Hospital
2020
China Medical University
2020
University of California, Berkeley
2016
Smith College
2016
QB3
2016
Howard Hughes Medical Institute
2016
Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit occurs remains elusive. We show human CaMKII holoenzyme exists dodecameric tetradecameric forms, calmodulin (CaM)-binding element can bind to hub destabilize it release dimers. structures from two distantly diverged organisms suggest CaM-binding activated acts as a wedge docking...
N6-methyladenosine (m6A) is the most prevalent epigenetic modification of messenger RNA (mRNA) in higher eukaryotes; this mainly catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as key factor. Although m6A has been proven to play an essential role diverse biological processes, our knowledge Mettl3 still limited because mutations are lethal embryos both mammals and plants. In study, we knocked down microinjection its specific short interfering RNAs (siRNAs)...
BackgroundLimited data exists on how early-life weight changes relate to metabolic syndrome (MetS) risk in midlife. This study examines the association between long-term trajectories of body mass index (BMI), its variability, and MetS Chinese individuals.MethodsIn Hanzhong Adolescent Hypertension (March 10, 1987–June 3, 2017), 1824 participants with at least five BMI measurements from 1987 2017 were included. Using group-based trajectory modeling, different identified. variability was...
Abstract Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted interventional trial to assess effects of altered salt intake on plasma urine UA levels the relationship between sensitivity in humans. Ninety subjects (18–65 years old) were sequentially maintained a normal diet 3 days at baseline, low-salt 7 (3.0 g/day, NaCl), high-salt additional (18.0 g/day NaCl). Plasma significantly increased from baseline decreased diet. By...
The ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) protein recognizes DNA methylation histone modification plays a critical role in epigenetic regulation. Recently, UHRF1 was shown to have oocytes early embryos. Here, we reveal that maternal determines the quality of mouse oocytes. We generated oocyte-specific Uhrf1-knockout mice found females were sterile, few UHRF1-null embryos developed into blastocysts. had an increased incidence aneuploidy damage. In addition...
Zygotic genomic activation (ZGA) is a landmark event in the maternal-to-zygotic transition (MZT), and regulation of ZGA by maternal factors remains to be elucidated. In this study, depletion ring finger protein 114 (RNF114), ubiquitin E3 ligase, led developmental arrest two-cell mouse embryos. Using immunofluorescence transcriptome analysis, RNF114 was proven play crucial role major ZGA. To study underlying mechanism, we performed profiling mature oocytes found potential substrate for...
<b><i>Background/Aims: </i></b>The aim of our study was to investigate the effect high-salt diet on renal expression renalase and potential role local renin-angiotensin system in this process. <b><i>Methods: </i></b>Sprague-Dawley (SD) rats were divided into groups according salt content drug treatment as follows: normal-salt (NS), (HS), intake with hydralazine (HS+H), enalapril (HS+E), valsartan (HS+V). The dietary intervention drugs given for...
Left atrial diameter (LAD) has been considered an independent risk factor for fibrillation (AF) relapse after pulmonary vein isolation (PVI). However, whether LAD or other factors are more predictive of late recurrence in patients with paroxysmal AF remains unclear. We aimed to evaluate the value (PV) parameters predicting 1 year underwent cryoablation AF. Ninety-seven who PVI successfully were included. PV measured through computed tomography scans prior PVI. A total 28 had at one-year...
Abstract Density functional theory was used to elucidate the mechanism and pericyclicity of chromium‐catalyzed bicyclization reactions that purportedly involve 8‐electron electrocyclization steps. Our computational results indicate these do indeed proceed via rather than an alternative pathway involving 4‐electron followed by Cope rearrangement. The role C=[M] groups on electrocyclization, specifically its pericyclicity, examined in detail using modern theoretical tools.
Objective: Data on the association between longitudinal patterns of weight change in early life and incidence metabolic syndrome (MetS) midlife are limited. This study aims to investigate long-term trajectories body mass index (BMI), its variability, risk MetS Chinese subjects. Design method: The prospective Hanzhong Adolescent Hypertension began 1987, present included 1824 participants with at least five BMI measurements available from 1987 2017. We used group-based trajectory modeling...
Background Salt reduction are crucial in the management of hypertension. Over past few decades, Series national activities and studies focusing on salt intake education were promoted by Chinese government. However, current status dietary sodium potassium population is unclear. Objective The aim this study to analyze through summarizing previous from 1998 2011 then propose appropriate initiatives. Design Relevant considered for review if they satisfied following criteria: 1) Papers reported...
Objectives: To investigate the effect of high salt on level adiponectin in SD rats and expression AMPK its sodium metabolism kidney. Methods: were randomized to a normal diet, diet + hydralazine intervention. After 8 weeks, SBP albuminuria analyzed, was evaluated by ELISA. Renal pAMPK activity Western Blot. Results: (1) two weeks intervention, higher than group (P < 0.01); later, average significantly 0.01). (2) 24 h urinary excretion At same time, comparing with group, protein increased (3)...
Objectives: Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted interventional trial to assess the effects of altered salt intake on plasma urine UA levels relationship between sensitivity in humans. Methods: Ninety subjects (18–65 years age) were selected from a rural community northern China. All sequentially maintained normal diet three days at baseline, low-salt 7 (3.0 g/day, NaCl), high-salt additional (18.0 g/day NaCl)....