A5079804745- Gene expression and cancer classification
- Blood Pressure and Hypertension Studies
- Molecular Biology Techniques and Applications
- Cardiovascular Health and Disease Prevention
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Birth, Development, and Health
- Advanced Biosensing Techniques and Applications
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Sodium Intake and Health
- Cancer-related gene regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Virus-based gene therapy research
- Cancer Research and Treatments
- Heart Rate Variability and Autonomic Control
- Obesity, Physical Activity, Diet
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Epigenetics and DNA Methylation
Shenzhen Technology University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2015-2023
Army Medical University
2021-2023
Southwest Hospital
2021-2023
Xi'an Jiaotong University
2015-2022
Chinese Preventive Medicine Association
2022
Shenyang Pharmaceutical University
2022
Inner Mongolia Agricultural University
2021
Southern Medical University
2007-2018
Shantou University
2012
Abstract Background The triglyceride-glucose index (TyG index) has emerged as a reliable surrogate marker of insulin resistance associated with arterial stiffness. However, most studies were based on cross-sectional design, and few have evaluated the longitudinal impact TyG This study aimed to investigate associations single time point measurement long-term trajectory stiffness in Chinese cohort. Methods Data are derived from Hanzhong Adolescent Hypertension Cohort study. A total 2480...
MicroRNAs are a class of small non-coding RNAs that involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose this study was to investigate the effect miR-32 on cell proliferation, migration apoptosis determine functional connection between FBXW7 breast cancer.In study, quantitative RT-PCR used evaluate levels 27 cancer tissues, adjacent normal tissues human lines. biological functions MCF-7 cells were determined assays...
Background Although high BP is one of the most important factors affecting renal function, whether longitudinal trajectories in early life course are associated with function damage later unclear. Methods To investigate correlation between from childhood to adulthood and middle age, we used group-based trajectory models identify 2430 individuals (aged 6–15 years old at baseline) participating ongoing Hanzhong Adolescent Hypertension Cohort. We tested association these subclinical adjusting...
Abstract Cancer stemness represents a major source of development and progression colorectal cancer (CRC). c-Met critically contributes to CRC stemness, but how is activated in remains elusive. We previously identified the lipolytic factor ABHD5 as an important tumour suppressor gene CRC. Here, we show that loss promotes activation sustain non-canonical manner. Mechanistically, demonstrate interacts cytoplasm with core subunit SET1A methyltransferase complex, DPY30, thereby inhibiting...
Abstract Purpose Soil microorganisms play an indispensable role in the material and energy cycle of grassland ecosystems. The abundance these organisms vary according to environmental factors, such as time year soil depth. There have been few studies on transformation microbial communities degraded typical steppe temporal spatial changes. In this study, we analyze community structure diversity bacteria fungi, impact changing factors upon structure. Methods From May September 2018, collected...
MicroRNAs (miRNAs) can function as tumor suppressors or oncogene promoters during development. In this study, low levels of expression miR-196b were detected in patients with chronic myeloid leukemia. Bisulfite genomic sequencing PCR and methylation-specific used to examine the methylation status CpG islands promoter K562 cells, leukemia healthy individuals. The showed more compared individuals (P<0.05), which indicated that may be associated an increase islands. dual-luciferase reporter...
Abstract Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted interventional trial to assess effects of altered salt intake on plasma urine UA levels the relationship between sensitivity in humans. Ninety subjects (18–65 years old) were sequentially maintained a normal diet 3 days at baseline, low-salt 7 (3.0 g/day, NaCl), high-salt additional (18.0 g/day NaCl). Plasma significantly increased from baseline decreased diet. By...
Bone sialoprotein (BSP) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin cementum. Although role for BSP mineralization has been indicated, also appears to function patho-physiological processes, the metastasis of breast prostate cancer cells bone. The purpose this study was determine homing provide insights into physiological as well pathological processes. We established cultures MDA-231 stably transfected with DNA...
Abstract High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA urinary sodium excretion, as well its interaction on risk of prehypertension. A total 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi Province, China. The classified normotensive or prehypertensive basis their blood pressure. Increasing quartiles excretion UA/creatinine levels...
Objective: Atherosclerotic diseases are the leading cause of death worldwide. This study aimed to investigate predictors brachial–ankle pulse wave velocity (baPWV) and carotid intima–media thickness (CIMT) progression in a Chinese cohort over 12-year follow-up period determine whether these differ by time. Methods: A total 202 participants were recruited from previously established Shaanxi Province, China. Both baPWV CIMT measured 2013 2017. Multivariable regression was used progression....
Obesity and hypertension play important roles in the development of arterial stiffness. We aimed to examine sex differences impact cumulative long-term burden trends body mass index (BMI) blood pressure (BP) since childhood on adult stiffness (AS).This longitudinal study consisted 1553 individuals aged 6-15 years, who were examined 4 or more times for BMI BP childhood, with a follow-up period 30 years. The area under curve (AUC) was calculated as measure (total AUC) (incremental from...
Cell cycle progression is regulated by both transcriptional and post-transcriptional mechanisms. MicroRNAs (miRNAs) emerge as a new class of small non-coding RNA regulators cell recent evidence suggests. It hypothesized that expression specific miRNAs oscillates orderly along with progression. However, the oscillated patterns many candidate have yet to be determined. Here, we describe miRNA profiling in double-thymidine synchronized HeLa cells progresses. Twenty-five differentially expressed...
The oncogene, microRNA-155, is significantly elevated in GBM (glioblastoma multiforme), regulating multiple genes associated with cancer cell proliferation, apoptosis and invasiveness. Thus, miR-155 can theoretically become a target for enhancement of the chemotherapy cancer. Down-regulating to enhance effect taxol has not been studied human GBM. Human U251 cells were treated inhibitor alone or combination. IC50 values dramatically decreased combined taxol, greater extent than those alone....