A5100449495- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Genetics, Aging, and Longevity in Model Organisms
- Redox biology and oxidative stress
- Bacterial biofilms and quorum sensing
- PI3K/AKT/mTOR signaling in cancer
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Protein Structure and Dynamics
- Biochemical and Molecular Research
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Microbial Metabolic Engineering and Bioproduction
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Plant biochemistry and biosynthesis
- Drug Transport and Resistance Mechanisms
- Nuts composition and effects
- Birth, Development, and Health
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Biofuel production and bioconversion
- Pregnancy and preeclampsia studies
Chinese Academy of Sciences
2016-2025
National Cheng Kung University Hospital
2025
University of Chinese Academy of Sciences
2016-2025
China Academy of Chinese Medical Sciences
2025
Czech Academy of Sciences, Institute of Biophysics
2022-2025
Shenzhen Second People's Hospital
2024
South China Sea Institute Of Oceanology
2011-2024
Institute of Oceanology
2010-2024
Institute of Biophysics
2015-2024
Chinese Institute for Brain Research
2015-2024
Endothelin-1 is implicated in the pathogenesis of hypertension, but underlying mechanisms remained elusive. Our previous study found that inhibition mitochondrial fission smooth muscle cells suppressed phenylephrine- and high K+-induced artery constriction. Here, we studied effects inhibitors on endothelin-1-induced vasoconstriction.The tension rat mesenteric arteries thoracic aorta was measured by using a multi-wire myograph system. Mitochondrial morphology aortic observed transmission...
Heterochromatin in aging stem cells Analysis of human syndromes, such as Werner syndrome (WS), may lead to greater understanding both premature and normal aging. Zhang et al. generated isogenic WS-specific embryonic cell lines (see the Perspective by Brunauer Kennedy). WS-mesenchymal displayed features characteristic aging, including heterochromatin disorganization. WRN protein thus functions maintenance heterochromatin, alterations represent a driving force Science , this issue p. 1160 ;...
The use of alkaline salt lands for crop production is hindered by a scarcity knowledge and breeding efforts plant tolerance. Through genome association analysis sorghum, naturally high-alkaline-tolerant crop, we detected major locus, Alkaline Tolerance 1 (AT1), specifically related to alkaline-salinity sensitivity. An at1 allele with carboxyl-terminal truncation increased sensitivity, whereas knockout AT1 tolerance alkalinity in millet, rice, maize. encodes an atypical G protein γ subunit...
Moonlighting proteins comprise a class of multifunctional in which single polypeptide chain performs multiple biochemical functions that are not due to gene fusions, RNA splice variants or pleiotropic effects. The known moonlighting perform variety diverse many different cell types and species, information about their structures is scattered publications. We have constructed the manually curated, searchable, internet-based MoonProt Database (http://www.moonlightingproteins.org) with over 200...
Type VI protein secretion systems (T6SS) are essential for virulence of several Gram-negative bacteria. In this study, we identified a T6SS in Vibrio anguillarum, marine bacterium that causes hemorrhagic septicemia fish. A partial operon vtsA-H (vibrio type six secretion) was sequenced and shown to encode eight proteins. VtsE-H signature proteins found other T6SSs, while VtsA-D not associated with studied so far. In-frame deletions were made each gene. Secretion haemolysin-co-regulated-like...
Cardiac hypertrophy involves a remodeling process of the heart in response to diverse pathological stimuli. Both calcineurin/nuclear factor activated T cells pathway and microRNA-133 (miR-133) have been shown play critical role cardiac hypertrophy. It has recognized that expression activity calcineurin increases miR-133 decreases hypertrophic heart, inhibition or increase protects against Here we tested interaction between vivo vitro was induced by transverse aortic constriction...
Identifying the key factor mediating pathological cardiac hypertrophy is critically important for developing strategy to protect against heart failure. Bone morphogenetic protein-4 (BMP4) a mechanosensitive and proinflammatory gene. In this study, we investigated role of BMP4 in hypertrophy, apoptosis, fibrosis experimentally hypertrophy. The vivo models were induced by pressure-overload angiotensin (Ang) II constant infusion mice, vitro model was Ang exposure cultured cardiomyocytes....
There are sex differences in many inflammatory and immune diseases, the tend to diminish after menopause. The underlying reasons unclear, but hormone levels likely be an important factor. Blood leukocyte count composition provide indicator of status individual. We performed a cross-sectional analysis blood data from 46,879 individuals (26,212 men 20,667 women, aged 18 93 years) who underwent routine health checkup. In women around 50 years, neutrophil percentage (NE%) dropped whilst...
Aging is tightly associated with redox events. The free radical theory of aging indicates that imbalance may be an important factor in the process. Most studies about and focused on static status oxidative stress levels, there has been little research investigating differential responses to challenge during aging. In this study, we used Caenorhabditis elegans human fibroblasts as models compare young old individuals. response paraquat stress, individuals generated more ROS activated...
MoonProt 2.0 (http://moonlightingproteins.org) is an updated, comprehensive and open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins contain two or more physiologically relevant distinct functions performed by a single polypeptide chain. Here, we describe developments in the website since our previous report Database Issue of Nucleic Acids Research. For this V release, expanded number annotated to 370 modified several dozen protein with...
The majority of diabetic patients develop neuropathy and there is an increasing prevalence neurodegeneration in the central nervous system (CNS). However, mechanism behind this poorly understood. Here we first observed that macroautophagy/autophagy was suppressed hippocampus GK rats with hyperglycemia, whereas it unchanged ob/ob mice without hyperglycemia. Autophagy could be directly inhibited by high glucose mouse primary hippocampal neurons. Moreover, autophagy protective...
Abstract Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent liver protection effects on several liver‐related diseases. However, the anti‐inflammatory potential of celastrol in fibrosis and detailed mechanisms remain uncovered. This study was to investigate effect further reveal celastrol‐induced with focus AMPK‐SIRT3 signalling. Celastrol showed ameliorative both activated hepatic stellate cells (HSCs) fibrotic liver. remarkably suppressed...
Abstract Herein, we report on the design of a programmable DNA ribbon using long‐chain molecules with user‐defined repetitive padlock sequence. The can be further combined gold nanoparticles (AuNPs) to create composite nanomaterial that contains an AuNP core and high‐density crown carrying cancer‐cell‐targeting aptamer, fluorescent tag for location tracking, cell‐killing drug. This material efficiently internalized by cancer cells its cellular tracked fluorescence imaging. system offers...
Over 50 billion cells undergo apoptosis each day in an adult human to maintain immune homeostasis. Hydrogen sulfide (H
Enzymatic reaction kinetics are central in analyzing enzymatic mechanisms and target-enzyme optimization, thus biomanufacturing other industries. The enzyme turnover number (kcat) Michaelis constant (Km), key kinetic parameters for measuring catalytic efficiency, crucial the directed evolution of target enzymes. Experimental determination kcat Km is costly terms time, labor, cost. To consider intrinsic connection between further improve prediction performance, we propose a universal...
Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1, abbreviated as APE1) is a molecule with dual functions in DNA repair and redox regulation of transcription factors. Accumulated work has shown that the biological activities APE1 are sensitive to oxidative stress; however, whether can be regulated by nitrosative stress remains unknown. In this investigation, we found S-nitrosoglutathion (GSNO), nitric oxide donor also an S-nitrosating agent, effectively stimulated...