A5100599894- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Cancer Genomics and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Facial Rejuvenation and Surgery Techniques
- Systemic Lupus Erythematosus Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Effects and risks of endocrine disrupting chemicals
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Toxic Organic Pollutants Impact
- Reconstructive Facial Surgery Techniques
- Melanoma and MAPK Pathways
- Advanced Nanomaterials in Catalysis
- Skin Protection and Aging
Yanbian University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Guang’anmen Hospital
2025
First People’s Hospital of Zunyi
2013-2025
Anhui University of Traditional Chinese Medicine
2025
Peking University
2015-2024
Peking University Cancer Hospital
2015-2024
Sun Yat-sen University
2017-2024
Sun Yat-sen University Cancer Center
2022-2024
Soochow University
2023-2024
Abstract Background The programmed cell death‐1/programmed death‐1 ligand ( PD ‐1/ ‐ L 1) pathway plays a crucial role in tumor evasion. This study evaluated the association between circulating ‐L1 expression and clinical characteristics patients with advanced non‐small lung cancer NSCLC ). Methods A total of 109 65 healthy from B eijng C ancer H ospital were enrolled study. Circulating 1 was tested by enzyme‐linked immunosorbent assay. associations level clinicopathologic features prognosis...
This randomized, controlled clinical trial aims to compare the efficacy and safety of glucocorticoid combined with MMF monotherapy for patients IgG4-related disease. Sixty-nine newly diagnosed disease were randomly divided into two groups (35 in Group I 34 II). Patients received (0.6–0.8 mg/(kg·day) tapered gradually); II therapy (1–1.5 g/day). All followed up at 1, 3, 6 12 months. The primary endpoint was response rate months secondary endpoints relapse, remission adverse reactions. shared...
Abstract Aim to evaluate the efficacy and safety of glucocorticoid monotherapy vs combination therapy cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD). 102 newly diagnosed IgG4-RD patients were enrolled assigned 2 groups: Group I was prednisone (0.5–1.0 mg/kg.d, tapered gradually) II CYC (50–100 mg per day). Patients assessed at different periods. Primary end point relapse rate; secondary points included response, remission rate adverse effects. 52 in 50 II. At 1 month, both groups...
This phase 2b, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of telitacicept, a novel fusion protein that neutralises signals B lymphocyte stimulator proliferation-inducing ligand, in active systemic lupus erythematosus (SLE).
To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with at pathophysiologically relevant concentrations. Secretion levels interleukin-6 (IL-6), tumor necrosis factor- α (TNF- α), interleukin-1 β (IL-1 β), NF- κ B nuclear translocation, activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPAR α) mRNA protein levels, as well cell proliferation ability measured end treatment...
A method was developed to determine nine environmental phenols, including bisphenol A, 2,3,4-trichlorophenol, 2,4,5-trichlorophenol, pentachlorophenol, triclosan (2,4,4'-trichloro-2'-hydroxyphenylether), 4-tert-octylphenol, 4-n-octylphenol, 4-n-nolyphenol and benzophenone-3 (2-hydroxy-4-methoxybenzophenone) in human urine using ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC–MS-MS). The analytes were extracted preconcentrated with solid-phase extraction, then...
Objective This study was aimed to evaluate the anti-photoaging effects of baicalin on Ultraviolet B (UVB)-induced photoaging in dorsal skin hairless mice and premature senescence human dermal fibroblasts. Methods We established vivo vitro models by repeated exposures UVB irradiation. By HE staining, masson immunohistostaing real-time RT-PCR, we analyzed epidermal thickness, collagen expression mRNA protein levels type I collagen, III interstitial collagenase (MMP-1 MMP-3) exposed skin. The...
Autophagy is a cellular catabolic mechanism that activated in response to stress conditions, including ultraviolet (UV) irradiation, starvation, and misfolded protein accumulation. Abnormalities autophagy are associated with several pathologies, aging cancer. Furthermore, recent studies have demonstrated microRNAs (miRNAs) potent modulators of the pathway. As result, current study aims elucidate role autophagy-related miRNA miR-23ain process photoaging. Experiments antagomir-mediated...
Enhanced aldehyde dehydrogenase (ALDH) activity has been shown to serve as a hallmark for cancer stem cells (CSCs). Recent evidence suggests that its role cell-related marker come down the specific isoform. However, little is known about ALDH isoform contributing aldefluor in gastric cancer. In this study, we isolated ALDHbright from 2 human cell lines MKN-45 and SGC‑7901 by using an Aldefluor assay found elevated self-renewal, differentiation tumorigenicity, demonstration of stemness...
Programmed cell death-1/programmed death ligand-1 (PD-1/PD-L1) inhibitors are increasingly used in China, but no real-world data available about the immune-related adverse events (irAEs). This retrospective study aimed to assess safety and effectiveness of PD-1/PD-L1 patients with non-small lung cancer (NSCLC) analyze association between irAEs effectiveness.This was a clinical NSCLC treated from August 2016 November 2019 at Beijing Cancer Hospital. The were divided into irAE or non-irAE...
Small cell lung cancer (SCLC) is characterized by aggressive spread and poor prognosis, but has limited treatment options. Results of prognostic factors from randomized trials on arrangement are conflicting large-scale real-world analysis lacking.Patients diagnosed SCLC between 2008 2018 in Peking University Cancer Hospital were included this study. Kaplan-Meier methods adopted, univariate multivariate Cox regression models constructed to analyze factors.Among 1045 patients who presented our...
Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is key period for prevention control adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer viable approach to prevent slow down progression. Nonetheless, these lack robust, high-quality, large-scale, multi-center evidence conclusively support such assertions. purpose this research...
Convergent Cross Mapping (CCM) is a powerful method for detecting causality in coupled nonlinear dynamical systems, providing model-free approach to capture dynamic causal interactions. Partial (PCM) was introduced as an extension of CCM address indirect three-variable systems by comparing cross-mapping quality between direct cause-effect mapping and through intermediate conditioning variable. However, PCM remains limited univariate delay embeddings its processes. In this work, we extend the...
This study explores the mechanisms of Astragaloside A (AS-A), a significant active ingredient in Astragalus, traditional Chinese medicine is both medication and food, combating lung adenocarcinoma using network pharmacology, molecular docking, dynamics, experimental validation. protein-protein interaction (PPI) was developed, identifying 10 key targets, including STAT3 AKT1. GO KEGG enrichment analyses indicated that these targets primarily participated biological processes pathways,...
The article evaluates and predicts the effectiveness of medical English teaching through stepwise regression analysis in multivariate method. It constructs an analytical prediction model evaluation based on analysis. After initially establishing index system teaching, effective indexes are screened out regression, is constructed, multiple equations for quality (students’ performance English) established. constructed by eliminating influential factors abnormal data that do not have...