A5088938516- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Osteoarthritis Treatment and Mechanisms
- Water Treatment and Disinfection
- Mercury impact and mitigation studies
- Chemical Analysis and Environmental Impact
- DNA Repair Mechanisms
- Respiratory viral infections research
- Sperm and Testicular Function
- Lung Cancer Research Studies
- Analytical chemistry methods development
- Reproductive System and Pregnancy
- Inflammatory mediators and NSAID effects
- Hepatitis C virus research
- Environmental Toxicology and Ecotoxicology
- Global Health Care Issues
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Genetic Associations and Epidemiology
- Bone Metabolism and Diseases
Center for Disease Control
2024-2025
Nanjing Medical University
2008-2025
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Bengbu Medical College
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2023
First Affiliated Hospital of Zhengzhou University
2016-2023
Chinese Center For Disease Control and Prevention
2016-2023
Institute of Hematology & Blood Diseases Hospital
2023
Hainan General Hospital
2022
Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline a community-based longitudinal study of Chinese elderly.The included 1,159 aged over 60 years (women: 48.7%, mean age: 79.4 years), who free dementia, Parkinson disease stroke at baseline. Blood total (TC), high-density lipoprotein (HDL-C), low-density (LDL-C),...
The size of any causal contribution central and general adiposity to CKD risk the underlying mechanism mediation are unknown.Data from 281,228 UK Biobank participants were used estimate relevance waist-to-hip ratio body mass index (BMI) prevalence. Conventional approaches logistic regression. Genetic analyses Mendelian randomization (MR) data 394 773 BMI-associated loci. Models assessed role known mediators (diabetes mellitus BP) by adjusting for measured values (conventional analyses) or...
Phytoestrogens (PEs) are naturally occurring chemical constituents of certain plants. The internal PE exposures, mainly from diet, vary among different populations and in regions due to various eating habits. To investigate the potential relationship between urinary levels idiopathic male infertility semen quality Chinese adult males, 608 infertile men 469 fertile controls were recruited by eligibility screening procedures. Individual exposure PEs was measured using UPLC–MS/MS as spot...
A method was developed to determine nine environmental phenols, including bisphenol A, 2,3,4-trichlorophenol, 2,4,5-trichlorophenol, pentachlorophenol, triclosan (2,4,4'-trichloro-2'-hydroxyphenylether), 4-tert-octylphenol, 4-n-octylphenol, 4-n-nolyphenol and benzophenone-3 (2-hydroxy-4-methoxybenzophenone) in human urine using ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC–MS-MS). The analytes were extracted preconcentrated with solid-phase extraction, then...
Most of the general populations are exposed to polycyclic aromatic hydrocarbons (PAHs) at different levels. A limited number studies have suggested that PAHs exposure may be associated with semen quality. To examine association four PAH metabolites, 1-hydroxynapthalene (1-N), 2-hydroxynapthalene (2-N), 1-hydroxypyrene (1-OHP) and 2-hydroxyfluorene (2-OHF) altered quality, 542 subjects were recruited through clinic following strict eligibility screening. Using LC-MS/MS, individual exposures...
X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing polycyclic aromatic hydrocarbons (PAHs)-induced DNA damage. We examined the effects of exposure to PAHs and XRCC1 polymorphism, alone or combined, on sperm integrity male fertility. A total 620 idiopathic infertile subjects 273 fertile controls were recruited this study. was indicated by urinary 1-hydroxypyrene level. Genotypes determined PCR-RFLP, damage detected Tdt-mediated dUTP nick end labelling assay using flow...
Objective The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate therapeutic role Thiolutin (THL), an inhibitor inflammasome, on oligoasthenospermia (OA) and elucidate its mechanisms.
Abstract Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalance in synovial inflammatory microenvironment, which accelerates progression OA. Despite this knowledge, specific molecular mechanisms synovium affect OA are still unclear. Methods Both vitro vivo experiments were undertaken explore role ADAM8 playing A small...
Human exposure to disinfection by-products (DBPs) primarily occurs through the consumption of drinking water.
Osteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain disability. Macrophages in synovium are important mediators of synovial inflammatory activity pathological pain. Previous studies have demonstrated significant involvement κ-opioid receptor (KOR) regulation inflammation. Our study reveals reduction KOR expression among patients mice with OA. Here, we find activation effectively inhibits expressions LPS-induced-inflammatory cytokines...
Abstract Background Whether measures of central adiposity are more or less strongly associated with risk albuminuria than body mass index (BMI), and by how much diabetes/levels glycosylated haemoglobin (HbA1c) explain modify these associations, is uncertain. Methods Ordinal logistic regression was used to estimate associations between values (waist-to-hip ratio) and, separately, general (BMI) categories urinary albumin-to-creatinine ratio (uACR) in 408,527 UK Biobank participants. Separate...