A5101565354- Pharmacogenetics and Drug Metabolism
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Hormonal Regulation and Hypertension
- Animal Genetics and Reproduction
- Reproductive biology and impacts on aquatic species
- Protein Hydrolysis and Bioactive Peptides
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Effects and risks of endocrine disrupting chemicals
- Nuclear Receptors and Signaling
- Birth, Development, and Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture disease management and microbiota
- Pharmacological Effects and Toxicity Studies
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Parkinson's Disease Mechanisms and Treatments
- Aldose Reductase and Taurine
- Drug Transport and Resistance Mechanisms
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
Wenzhou Medical University
2013-2025
Fujian Agriculture and Forestry University
2024
Jinzhou Medical University
2023
Kunming University of Science and Technology
2016-2023
South China Agricultural University
2020-2023
Weifang University
2021
Heilongjiang University of Chinese Medicine
2021
University of Shanghai for Science and Technology
2018-2021
Fujian Medical University
2019
Qingdao University
2019
The objective of this study was to purify cells in the Leydig cell lineage following regeneration after ethane dimethanesulfonate (EDS) treatment and compare their steroidogenic capacity. Regenerated progenitor (RPLCs), immature (RILCs), adult (RALCs) were isolated from testes 21, 28 56 days EDS respectively. Production rates for androgens including androsterone 5α-androstane-17β, 3α-diol (DIOL), testosterone androstenedione measured RPLCs, RILCs RALCs media 3-h vitro culture with 100 ng/ml...
Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, turn, increase the risk of certain cancers. The coexistence these diseases makes use combination drugs more common clinical practice, but potential interactions and regulatory mechanisms drug combinations are poorly understood. We humanized CYP2D6 mouse model to predict effect apatinib on pharmacokinetics pharmacodynamics metoprolol investigated...
As the risk of extreme fault conditions to power supply reliability escalates, importance recovery within active distribution networks (ADNs) is exponentially increasing. However, utilization a single resource strategy insufficient fully exploit potential ADN’s diverse and flexible resources. Therefore, coordination for ADN considering multiple demand responses proposed. This utilizes distributed generation (DG) energy storage system (ESS) as units, involves operational flexibility soft open...
Chinese medicine, as a treasure of China’s traditional culture, has long history and deep cultural heritage, talents are the first resource for development medicine. In ancient times, there were many famous medicine practitioners with excellent medical skills fame, their main ways success through teaching family tradition. The cultivation high ethics, benevolence love, helping world people is source motivation success; familiarizing oneself classics, understanding humanities, being...
Pearl oyster meat, a by-product of pearl production, is rich in protein, but has low utilization rate. Our previous study showed that meat hydrolysates have potential anti-inflammatory activity. In this study, highly active peptides from were purified, identified, and extracted, their activity was further investigated. A total 206 three novel peptides, TWP (402.1903 Da), TAMY (484.1992 Da) FPGA (390.1903 screened by molecular docking. The docking results TWP, can bind to key regions the...
Objective The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate therapeutic role Thiolutin (THL), an inhibitor inflammasome, on oligoasthenospermia (OA) and elucidate its mechanisms.
BackgroundThe purpose of this study is to describe the prevalence overweight, general obesity, and abdominal obesity examine their associations with socioeconomic status in a rural Chinese adult population. MethodsThis cross-sectional was performed on 15,236 participants ≥ 35 years age (6,313 men [41.4%] 8,923 women [58.6%]). Each participant's weight, height, waist circumference (WC), hipline (HC) were measured, demographic data collected using questionnaires. ResultsThe mean body mass...
Although sperm cryopreservation has been widely used in human reproductive medicine as an integral infertility management clinics and for banking banks, the freezing/thawing protocols are not optimal. The freezing thawing processes result changes at both structural molecular levels, some even detrimental, when compared with fresh sperm. change of proteins after may play negative roles fertilization early embryo development. Conventionally, cryostraws (CS) cryovials (CV) most carriers (CPCs)...
In this study, the effects of different dietary iron levels on growth performance, body composition and antioxidant responses were investigated in coho salmon Oncorhynchus kisutch alevins. Six experimental diets formulated to contain graded (23.7, 46.4, 59.8, 77.3, 101.7 127.7 mg/kg) provided as FeSO4∙7H2O. Each diet was fed triplicate groups alevins with initial mean weight 0.35 ± 0.02 g a flow-through rearing system for 84 days. The results showed that there no significant difference...
The objective of the present study is to determine whether methoxychlor (MXC) exposure in adulthood affects rat Leydig cell regeneration and compare its effects with estradiol (E2). Adult 90-day-old male Sprague-Dawley rats received ethane dimethane sulfonate (EDS) eliminate adult population. Subsequently, were randomly assigned four groups gavaged corn oil (control), 0.25 mg/kg E2 10 or 100 MXC daily from days 5 30 post-EDS treatment. results showed that reduced serum testosterone levels on...
Liver fibrosis is a disease that causes high morbidity and has become major health problem. can lead to the end stage of liver diseases (livercirrhosisand hepatocellularcarcinoma). Currently, transplantation only effective treatment for end-stage disease. However, shortage organ donors, cost medical surgery, immunological rejection complications severely hamper therapy. Mesenchymal stem cells (MSCs) have been regarded as promising clinical applications in cell therapy due their unique...
The aim of this study is to investigate the effects CYP3A4 genetic polymorphisms on metabolism cyclosporine (CsA) in vitro and identify drugs that interact with CsA. An enzymatic incubation system was developed evaluate kinetic parameters CsA catalysis. A total 132 were screened potential drug-drug interactions. Sprague-Dawley rats used determine interaction between nimodipine nisoldipine. metabolite AM1 measured by ultra-performance liquid chromatography-tandem mass spectrometry. results...
The cytochrome P450 2A1 (CYP2A1) is a enzyme that catalyzes the metabolism of testosterone. CYP2A1 has been reported to be present in rat testis. However, its developmental changes and function have not well characterized. purpose this study was measure abundance (Cyp2a1) mRNA developing testis Leydig cells examine effects product, 7α-hydroxytestosterone (7HT), on an important enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts active corticosterone inactive...