A5058702768- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Photochromic and Fluorescence Chemistry
- Nuclear Receptors and Signaling
- Magnetism in coordination complexes
- Neurological disorders and treatments
- Photochemistry and Electron Transfer Studies
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Cancer-related gene regulation
- Trace Elements in Health
- Biomedical Research and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Long-Term Effects of COVID-19
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Animal Genetics and Reproduction
- Digestive system and related health
- Electron Spin Resonance Studies
- Organic Light-Emitting Diodes Research
Qingdao University
2018-2024
Zhengzhou University
2022-2023
Olfactory dysfunction represents a prodromal stage in Parkinson's disease (PD). However, the mechanisms underlying hyposmia are not specified yet. In this study, we first observed an early olfactory mice with intragastric rotenone administration, consistent dopaminergic neurons loss and α-synuclein pathology bulb. much severer was without bulb when of substantia nigra occurred. Then, established models by intrastriatal preformed fibrils injection demonstrated performance discrimination test...
Nedd4 family interacting protein 1 (Ndfip1) is an adaptor of Nedd4-family ubiquitin ligases. Experimental results showed that Ndfip1 had a potential neuroprotective effect in neurology diseases. However, the and underlying mechanisms Parkinson's disease (PD) have not yet been fully elucidated. Therefore, this study, we explored against mitochondrial complex I inhibitor rotenone human dopaminergic neuroblastoma SH-SY5Y cell line further elucidated its possible mechanisms. Our could induce...
Iron is the most abundant transition metal in brain and essential for development neuronal function; however, its abnormal accumulation also implicated various neurological disorders. The olfactory bulb (OB), an early target neurodegenerative diseases, acts as a gateway environmental toxins contains diverse populations with distinct roles. This study explored cell-specific vulnerability to iron OB using mouse model of intranasal administration ferric ammonium citrate (FAC). Olfactory...
We report the first demonstration using π-conjugated radicals for reactive oxygen species (ROS) scavenging. The ester-derived 1,2,4-benzotriazinyl monoradical VER and its carboxyl counterpart VAR exhibit typical antiferromagnetic behavior with a thermally populated spin-triplet state. Upon self-assembly DSPE-PEG1000, formed ∼25 nm size nanoparticles (NPs) good water dispersibility stability, no obvious aggregation degradation were observed after storing at ambient environment 14 days. In...
Stable magnetic coordination particles based on π-conjugated 1,2,4-benzotriazinyl radical ligands were synthesized using a sonochemical method.
As a pathological biomarker of Parkinson’s disease, α-synuclein is thought to be prion-like protein, but evidence for the transmission from blood brain unclear. The goals this study were determine whether blood-derived could enter brains mice and in cleared by parabiosis. Heterochronic parabiosis was performed on SNCAA53T transgenic (A53T mice) wildtype mice. levels human substantia nigra significantly increased after 4-month with A53T Moreover, expression filament, not total α-synuclein,...