A5007913729- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Bat Biology and Ecology Studies
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Trace Elements in Health
- Sirtuins and Resveratrol in Medicine
- Inflammatory Bowel Disease
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Influenza Virus Research Studies
- Polysaccharides and Plant Cell Walls
- Marine animal studies overview
- Ideological and Political Education
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Biochemical effects in animals
- FOXO transcription factor regulation
- Heavy Metal Exposure and Toxicity
- Tryptophan and brain disorders
- Nephrotoxicity and Medicinal Plants
Hunan University of Traditional Chinese Medicine
2025
Johns Hopkins All Children's Hospital
2025
Johns Hopkins University
2025
University of Florida
2020-2024
Qingdao University
2008-2023
Dalian Medical University
2019
Central South University of Forestry and Technology
2015-2018
Central South University
2015-2018
Institute of Food Science & Technology
2015-2017
Yunnan Normal University
2014-2016
Maternal viral infection is known to increase the risk for schizophrenia and autism in offspring. Using this observation an animal model, we find that respiratory of pregnant mice (both BALB/c C57BL/6 strains) with human influenza virus yields offspring display highly abnormal behavioral responses as adults. As autism, these deficits prepulse inhibition (PPI) acoustic startle response. Compared control mice, infected also striking acute administration antipsychotic (clozapine chlorpromazine)...
Abstract Epidemiological studies have shown that maternal infection can increase the risk for mental illness in offspring. In a mouse model of respiratory with influenza virus, adult offspring display striking behavioral, pharmacological and histological abnormalities. Although primarily infects system, there are reports viral mRNA protein fetus infected pregnant animals. To determine extent spread following infection, we used RT–PCR to assay various fetal tissues A mRNAs coding...
Octacosanol has multiple biological functions. In this study, the anti-inflammatory effect and molecular mechanism of octacosanol were evaluated by using dextran sulfate sodium (DSS)-induced ulcerative colitis model in mice lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells. The was induced 3.0% DSS 8-week ICR orally administered with 100 mg/kg/day. results showed that significantly improved health status reduced DSS-induced pathological damage colonic tissues. obviously...
Oral administration of oat β-glucan ameliorates DSS induced colitis in mice by decreasing the expression inflammatory cytokines TNF-α, IL-1β, IL-6 and iNOS.
Hyperlipidemia occurs very often in modern society along with a high calorie intake and is regarded as one of the greatest risk factors for prevalence cardiac vascular disease (CVD). In this study, we investigated anti-hyperlipidemic effect rice bran polysaccharides (RBP) its mechanism fat diet animal model. 60 ICR mice were randomly divided into 3 groups, which included Control, HFD (high diet) + RBP, each group 20 mice. The control was fed standard while other two groups HFD. addition, RBP...
The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate function of nigrostriatal system for motor coordination. Here we describe a novel mechanism by which nigral inhibiting voltage-gated potassium Kv7/KCNQ/M-channels through its receptor GHS-R1a and activation PLC-PKC pathway. Brain slice recordings compacta reveal that inhibits native Kv7/KCNQ/M-currents. This effect is abolished selective...
Scope In this study, the anti-inflammatory effects and molecular mechanism of alliin were analyzed in dextran sulfate sodium (DSS)-induced colitis mice lipopolysaccharide-stimulated RAW264.7 cell model. Methods The phenotype was recorded DSS-induced and/or (500 mg/kg) groups. Histopathological alterations by H&E staining. MPO MDA colon tissues measured. mRNA expression levels inflammatory factors determined qRT-PCR, protein expressions or activation kinases Western blotting. Results Oral...
To evaluate the anti-inflammatory effect of β-glucans from<italic>Lentinus edodes</italic>, and its molecular mechanism, dextran sulfate sodium salt (DSS) induced colitis model mice LPS-stimulated RAW264.7 cell inflammation were used in this study.
Adipose plasticity is critical for metabolic homeostasis. Adipocyte transdifferentiation plays an important role in adipose plasticity, but the molecular mechanism of remains incompletely understood. Here we show that transcription factor FoxO1 regulates by mediating Tgfβ1 signaling pathway. treatment induced whitening phenotype beige adipocytes, reducing UCP1 and mitochondrial capacity enlarging lipid droplets. Deletion (adO1KO) dampened downregulating Tgfbr2 Smad3 browning tissue mice,...
Abstract Browning of white adipose tissue is hallmarked by increased mitochondrial density and metabolic improvements. However, it remains largely unknown how turnover quality control are regulated during browning. In the present study, we found that mice lacking adipocyte FoxO1, a transcription factor regulates autophagy, adopted an alternate mechanism mitophagy to maintain Post-developmental deletion FoxO1 (adO1KO) suppressed Bnip3 but activated Fundc1/Drp1/OPA1 cascade, concurrent with...
IL-2 gene expression in activated T-cells is initiated by chromatin remodeling at the proximal promoter and conversion of a transcriptional repressor into potent activator. A purine-box regulator complex was purified from Jurkat T-cell nuclei based on sequence-specific DNA binding to antigen receptor response element (ARRE)/nuclear factor (NF-AT) target sequence promoter. ARRE DNA-binding subunits were identified as NF90, NF45 systemic lupus erythematosis autoantigens, Ku80 Ku70. Monoclonal...
δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated purified from rice bran. The anti-inflammatory effect mechanism against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that significantly inhibited LPS-stimulated nitric...
Summary Inflammatory bowel disease ( IBD ) is highly prevalent worldwide and includes ulcerative colitis UC Crohn's disease. It a high incidence rate all over the world an inducement of colon cancer. The aim this study was to investigate potential protective effect Fuzhuan brick tea FBT against induced by dextran sulphate sodium DSS in mice. ICR mice were administered orally for 7 days before drinking 3% (w/v). significantly attenuated symptoms including diarrhoea, rectal bleeding loss body...
The aim of this study was to determine the therapeutic effect curcumin on dextran sulfate sodium-induced ulcerative colitis (UC) and explore related mechanism.Sixty mice were randomly divided into 6 groups.A group normal control group; B model C 1.5 mg/kg dexamethasone based D, E F groups 15, 30, 60 mg/ kg groups, respectively, group.The killed 7 days after treatment; expression TNF-α MPO in colon tissue determined with ELISA, p-p38MAPK p38MAPK mRNA evaluated by immunohistochemistry RT-PCR,...
Abstract Iron importer divalent metal transporter 1 (DMT1) plays a crucial role in the nigal iron accumulation Parkinson’s disease (PD). Membrane hyperpolarization is one of factors that could affect its transport function. Besides iron, selective activation ATP-sensitive potassium (K ATP ) channels also contributes to vulnerability dopaminergic neurons PD. Interestingly, K induce membrane hyperpolarization. Therefore, it vital importance study effects on DMT1-mediated uptake In present...