A5003624509- Schizophrenia research and treatment
- Animal Nutrition and Physiology
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Psychosomatic Disorders and Their Treatments
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Mental Health Treatment and Access
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Axon Guidance and Neuronal Signaling
- Listeria monocytogenes in Food Safety
- Muscle Physiology and Disorders
- Infant Health and Development
- Aquaculture Nutrition and Growth
- Maternal Mental Health During Pregnancy and Postpartum
Birmingham Women’s and Children’s NHS Foundation Trust
2018-2025
University of Birmingham
2008-2024
Institute for New Economic Thinking
2022-2024
Institute of Mental Health
2024
Pennsylvania State University
2014-2023
Primary Health Care
2022
University of Oxford
2022
University of Warwick
2022
Women’s Health Care
2022
Australian Regenerative Medicine Institute
2022
Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype environmental risk factors. The offspring of women who experience infection while pregnant have an increased for these disorders. Maternal immune activation (MIA) in rodents produces with abnormalities behavior, histology, gene expression that reminiscent schizophrenia autism, making MIA useful model However, mechanism by which causes long-term behavioral deficits is unknown. Here we show...
Maternal viral infection is known to increase the risk for schizophrenia and autism in offspring. Using this observation an animal model, we find that respiratory of pregnant mice (both BALB/c C57BL/6 strains) with human influenza virus yields offspring display highly abnormal behavioral responses as adults. As autism, these deficits prepulse inhibition (PPI) acoustic startle response. Compared control mice, infected also striking acute administration antipsychotic (clozapine chlorpromazine)...
Context: Indicated prevention is currently regarded as the most promising strategy to attenuate, delay, or even avert psychosis.Existing criteria need improvement in terms of specificity and individual risk assessment allow for better targeted earlier interventions.Objective: To develop a differential predictive clinical model transition first-episode psychosis.Design: Prospective multicenter, naturalistic field study with total follow-up time 18 months.Setting: Six early-detection...
A protein secreted by cultured rat heart cells can direct the choice of neurotransmitter phenotype made sympathetic neurons. Structural analysis and biological assays demonstrated that this is identical to a regulates growth differentiation embryonic stem myeloid cells, stimulates bone remodeling acute-phase synthesis in hepatocytes. This has been termed D factor, DIA, DIF, DRF, HSFIII, LIF. Thus, cytokine, like IL-6 TGFβ, embryo adult many tissues, now including nervous system.
Rat sympathetic ganglia were disrupted by mechanical agitation to yield dissociated primary neurons, and the conditions for long-term growth in culture of isolated neurons examined. The grown with or without non-neural cells, simply addition deletion bicarbonate during culture. Fluorescence histochemistry indicated that contained catecholamines; incubations radioactive precursors used verify synthesis accumulation both dopamine norepinephrine. also produced octopamine using tyramine as...
Expansion of the polyglutamine repeat within protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and accumulation mutant Htt in diseased neurons. Understanding mechanisms that influence cellular degradation may target treatments designed to activate clearance pathways. We find is phosphorylated by inflammatory kinase IKK, enhancing its normal proteasome lysosome. Phosphorylation regulates additional post-translational modifications,...
Brain injury, genetic manipulations, and pharmacological treatments can result in alterations of motor skills mice. Fine coordination balance be assessed by the beam walking assay. The goal this test is for mouse to stay upright walk across an elevated narrow a safe platform. This takes place over 3 consecutive days: 2 days training 1 day testing. Performance on quantified measuring time it traverse number paw slips that occur process. Here we report protocol used our laboratory,...
Increasing evidence highlights a role for the immune system in pathogenesis of autism spectrum disorder (ASD), as dysregulation is observed brain, periphery, and gastrointestinal tract ASD individuals. Furthermore, maternal infection (maternal activation, MIA) risk factor ASD. Modeling this mice yields offspring with cardinal behavioral neuropathological symptoms human In study, we find that immune-activated mothers display altered profiles function, characterized by systemic deficit CD4 +...
<b>Objective</b> To determine whether cognitive therapy is effective in preventing the worsening of emerging psychotic symptoms experienced by help seeking young people deemed to be at risk for serious conditions such as schizophrenia. <b>Design</b> Multisite single blind randomised controlled trial. <b>Setting</b> Diverse services five UK sites. <b>Participants</b> 288 participants aged 14-35 years (mean 20.74, SD 4.34 years) high psychosis: 144 were assigned plus monitoring mental state...
The effects of several non-neuronal cell types on neurotransmitter synthesis in cultures dissociated sympathetic neurons from the new-born rat were studied. Acetylcholine radioactive choline was increased 100- to 1000-fold presence cells ganglia. This increase roughly dependent number ganglionic present. effect did not appear be due an plating efficiency neurons, since capable increasing acetylcholine after only 48-hr contact with that had been previously grown without for 2 weeks. C6 glioma...
* Abbreviations: ASD — : autism spectrum disorder GI gastrointestinal 5-HT serotonin Autism disorders (ASDs) are a set of complex neurodevelopmental defined behaviorally by impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range interests. ASDs represent significant public health issue with recent estimates indicating that as many 1% children in the United States diagnosed an ASD.1,2 Many individuals have symptoms associated...
In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which multiple target mRNAs mapped a single sample, essential for studying regulatory interactions, but remain cumbersome most model organisms. Programmable amplifiers based on mechanism of chain reaction (HCR) overcome this longstanding challenge by operating independently enabling multiplexed experiments be performed with an experimental timeline...