A5004754581- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Psychiatric care and mental health services
- Autism Spectrum Disorder Research
- Mental Health Treatment and Access
- Treatment of Major Depression
- Neuroscience and Music Perception
- Circadian rhythm and melatonin
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Personality Disorders and Psychopathology
- Health and Medical Studies
- Stress Responses and Cortisol
University of Cologne
2016-2025
University Hospital Cologne
2011-2025
Universitat Autònoma de Barcelona
2025
Centro de Investigación Biomédica en Red de Salud Mental
2025
Scania (Sweden)
2021-2024
Lund University
2021-2024
Authorised Association Consortium
2024
University of Basel
2022-2023
Ludwig-Maximilians-Universität München
2023
Karolinska Institutet
2013-2022
Context: Indicated prevention is currently regarded as the most promising strategy to attenuate, delay, or even avert psychosis.Existing criteria need improvement in terms of specificity and individual risk assessment allow for better targeted earlier interventions.Objective: To develop a differential predictive clinical model transition first-episode psychosis.Design: Prospective multicenter, naturalistic field study with total follow-up time 18 months.Setting: Six early-detection...
This guidance paper from the European Psychiatric Association (EPA) aims to provide evidence-based recommendations on early intervention in clinical high risk (CHR) states of psychosis, assessed according EPA detection. The were derived a meta-analysis current empirical evidence efficacy psychological and pharmacological interventions CHR samples. Eligible studies had investigate conversion rate and/or functioning as treatment outcome patients defined by ultra-high basic symptom criteria....
Multiple sclerosis is an autoimmune disease that caused by the interplay of genetic, particularly HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating autoreactive CD4+ T cell repertoire not clear. Here, we demonstrate self-reactivity, defined as "autoproliferation" peripheral Th1 cells, elevated in patients carrying haplotype. Autoproliferation mediated memory B cells a HLA-DR-dependent manner. Depletion vitro therapeutically vivo...
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify attributable all interrogated variants. We have quantified variance liability disease explained by SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded point estimate 0.58 (se = 0.09, p 5.64e-12) TS, 0.37...
Social and occupational impairments contribute to the burden of psychosis depression. There is a need for risk stratification tools inform personalized functional-disability preventive strategies individuals in at-risk early phases these illnesses.To determine whether predictors associated with social role functioning can be identified patients clinical high-risk (CHR) states or recent-onset depression (ROD) using clinical, imaging-based, combined machine learning; assess geographic,...
The proper identification of differentially methylated CpGs is central in most epigenetic studies. Illumina HumanMethylation450 BeadChip widely used to quantify DNA methylation; nevertheless, the design an appropriate analysis pipeline faces severe challenges due convolution biological and technical variability presence a signal bias between Infinium I II probe types. Despite recent attempts investigate how analyze methylation data with such array design, it has not been possible perform...
Diverse models have been developed to predict psychosis in patients with clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining and biological broadening the risk spectrum young depressive syndromes remains unclear.To evaluate whether transition predicted CHR or recent-onset depression (ROD) using multimodal machine learning that optimally integrates neurocognitive data, structural magnetic resonance imaging (sMRI), polygenic scores (PRS) for...
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 particularly affected displays methylation-sensitive regulatory properties vitro. Causal inference Mendelian randomization provide evidence HLA variants mediate MS via changes DMR modify expression. Meta-analysis...
Abstract We report the cases of two drug‐resistant major depressed psychotic patients, who were treated with 10 sessions transcranial magnetic stimulations (TMS) and afterwards electroconvulsive therapy (ECT) without changing concomitant neuroleptic antidepressive medication. TMS did not exert a therapeutic effect in one patient only slight other. However, there was clear beneficial for ECT responding to In summary, no clear‐cut evidence effectiveness as treatment patients psychotic,...
Background Young people with self-experienced cognitive thought and perception deficits (basic symptoms) may present an early initial prodromal state (EIPS) of psychosis in which most the disability neurobiological schizophrenia have not yet occurred. Aims To investigate effects integrated psychological intervention (IPI), combining individual cognitive–behavioural therapy, group skills training, remediation multifamily psychoeducation, on prevention EIPS. Method A randomised controlled,...
Symptom development during the prodromal phase of psychosis was explored retrospectively in first-episode patients with special emphasis on assumed time-related syndromic sequence "unspecific symptoms (UN)–predictive basic (BS)–attenuated psychotic (APS)–(transient) (PS)." Onset syndromes defined by first occurrence any their respective symptoms. Group means were inspected for time differences between and influence sociodemographic clinical characteristics recalled sequence. The...
Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its initial prodromal states of psychosis. measured the levels and structural analog oleoylethanolamide cerebrospinal fluid serum patients state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal were significantly elevated. Patients with lower showed higher risk transiting...