Lisa Osiecki
A5009372831- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Williams Syndrome Research
- Genetic Associations and Epidemiology
- Eating Disorders and Behaviors
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Virology and Viral Diseases
- Trypanosoma species research and implications
- Child and Adolescent Psychosocial and Emotional Development
- Plant Virus Research Studies
- Schizophrenia research and treatment
- Plant Reproductive Biology
- Hereditary Neurological Disorders
- Child Nutrition and Feeding Issues
- Attention Deficit Hyperactivity Disorder
- Urticaria and Related Conditions
- Chromosomal and Genetic Variations
Harvard University
2012-2025
Massachusetts General Hospital
2015-2025
NeuroDevelopment Center
2021-2024
Harvard University Press
2023
Yale University
2021
Broad Institute
2014-2019
Stanley Foundation
2019
Center for Human Genetics
2010-2017
Brigham and Women's Hospital
2014-2017
VA Boston Healthcare System
2017
Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully these comorbidities. Furthermore, most included relatively participants (<200), and none has examined the ages highest risk for each TS-associated comorbidity or their etiologic relationship to TS.To characterize lifetime prevalence, clinical associations, risk, etiology among individuals with TS.Cross-sectional structured diagnostic interviews conducted between April 1, 1992,...
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify attributable all interrogated variants. We have quantified variance liability disease explained by SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded point estimate 0.58 (se = 0.09, p 5.64e-12) TS, 0.37...
Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex remains elusive. The authors report a combined genome-wide association study (GWAS) OCD. Method: conducted GWAS in 2,723 cases (1,310 with OCD, 834 syndrome, 579 OCD plus syndrome/chronic tics), 5,667 ancestry-matched controls, 290...
Obsessive-compulsive disorder (OCD) affects ~1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on genetic etiology underlying biological mechanisms disorder. We conducted GWAS meta-analysis combining 53,660 OCD cases 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent significant SNPs SNP-based heritability 6.7%. Separate for clinical, biobank, comorbid, self-report...
Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie neurobiology through genome-wide analysis. We analyzed genotypic data 3581 individuals with TS and 7682 ancestry-matched controls investigated associations sets genes are expressed in particular cell types operate specific neuronal glial functions. employed self-contained, set-based association method...
Abstract Tourette syndrome (TS) is a childhood‐onset neuropsychiatric disorder that familial and highly heritable. Although genetic influences are thought to play significant role in the development of TS, no definite TS susceptibility genes have been identified date. believed be genetically related both obsessive‐compulsive (OCD) grooming disorders (GD) such as trichotillomania (TTM). SAP90/PSD95‐associated protein 3 ( SAPAP3/DLGAP3 ) post‐synaptic scaffolding expressed glutamatergic...
Phenotypic heterogeneity in Tourette syndrome is partly due to complex genetic relationships among syndrome, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity (ADHD). Identifying symptom-based endophenotypes across diagnoses may aid gene-finding efforts.Assessments for OCD, ADHD symptoms were conducted a discovery sample of 3,494 individuals recruited studies. Symptom-level factor latent class analyses families replicated an independent 882 individuals. Classes...
Background The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns heritability OCD ADHD in TS families. Method were examined patients their family members ( N = 3494) using exploratory factor analyses (EFA) for symptoms separately, followed by latent class (LCA) the resulting sum scores jointly; clinical relevance factors...
Persistent motor or vocal tic disorder (PMVT) has been hypothesized to be a forme fruste of Tourette syndrome (TS). Although the primary diagnostic criterion for PMVT (presence tics, but not both) is clear, less known about its clinical presentation.The goals this study were compare prevalence and number comorbid psychiatric disorders, severity, age at onset, family history TS PMVT.We analyzed data from two independent cohorts using generalized linear equations confirmed our findings...
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from GWAS in the largest case-control sample (N = 14,140 cases and N 562,117 controls) to date. We explored genetic architecture of OCD, including its relationships other psychiatric non-psychiatric phenotypes. In analysis, one SNP associated with at significant level. Subsequent...
Tourette Syndrome (TS) and Persistent Motor or Vocal Tic Disorders (PMVT) are more prevalent in males (vs. females). Females with TS may have a delay diagnosis, complex tic features males). With respect to comorbidities, obsessive-compulsive disorder (OCD) is females; attention-deficit hyperactivity (ADHD) males. Less known about sex differences PMVT. This study analyzes outcomes among individuals PMVT the Association of America International Consortium for Genetics dataset (TAAICG).
To analyze sex differences in outcomes Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) the Association of America International Consortium for Genetics (TAAICG) dataset. The relationship between clinical measures was explored 2,403 participants (N = 2,109 with TS; N 294 PMVT) from TAAICG dataset using generalized estimating equation regression models, adjusted age family relationships. Female (vs male) TS (25.5% sample) had 0.46 times lower odds being formally...
Background The effects of the menstrual cycle on neuropsychiatric and physical symptoms have been examined in multiple psychiatric illnesses, but research Tourette syndrome (TS) menstruation is limited inconclusive. One study published 1992 reported that 34% female respondents experienced tic fluctuations with their cycles; however, a subsequent 2001 found no significant relationship between cycle-related hormonal changes across participants. There has further exploration this topic...
To identify heritable symptom-based subtypes of Tourette syndrome (TS).