A5086589946- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Genetic Associations and Epidemiology
- Digital Mental Health Interventions
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Impact of Technology on Adolescents
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Stuttering Research and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Social and Educational Sciences
- Cardiac Health and Mental Health
- Acute Myocardial Infarction Research
- Eating Disorders and Behaviors
- Behavioral and Psychological Studies
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Language Development and Disorders
- Eosinophilic Esophagitis
- Resilience and Mental Health
- Family and Disability Support Research
- Reproductive System and Pregnancy
Karolinska Institutet
2018-2025
Stockholm Health Care Services
2019-2025
Humboldt-Universität zu Berlin
2024
California University of Pennsylvania
2023
The London College
2023
University of Gothenburg
2023
Karolinska University Hospital
2021-2022
Child Health and Development Institute
2021
Stockholm County Council
2021
Uppsala University
2016
Importance Cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) is a highly specialized treatment that in short supply worldwide. Objectives To investigate whether both therapist-guided and unguided internet-based CBT (ICBT) are noninferior to face-to-face adults with OCD, conduct health economic evaluation, determine effects were moderated by source of participant referral. Design, Setting, Participants This study single-blinded, noninferiority, randomized clinical...
Abstract Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on genetic etiology underlying biological mechanisms disorder. We conducted GWAS meta-analysis combining 53,660 OCD cases 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent significant SNPs SNP-based heritability 6.7%. Separate for clinical, biobank, comorbid,...
This study applied supervised machine learning with multi-modal data to predict remission of major depressive disorder (MDD) after psychotherapy. Genotyped adult patients (n = 894, 65.5% women, age 18-75 years) diagnosed mild-to-moderate MDD and treated guided Internet-based Cognitive Behaviour Therapy (ICBT) at the Internet Psychiatry Clinic in Stockholm were included (2008-2016). Predictor types demographic, clinical, process (e.g., time complete online questionnaires), genetic (polygenic...
To date, four genome-wide association studies (GWAS) of obsessive-compulsive disorder (OCD) have been published, reporting a high single-nucleotide polymorphism (SNP)-heritability 28% but finding only one significant SNP. A sub-stantial increase in sample size will likely lead to further identification SNPs, genes, and biological pathways mediating the susceptibility OCD. We conducted GWAS meta-analysis with 2-3-fold case (OCD cases: N = 37,015, controls: 948,616) compared last OCD GWAS,...
A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors change in symptom severity after treatment could inform clinical decision-making, allow better-tailored interventions, and avoid failure. Prior research on response has, however, yielded inconsistent findings with limited utility. Here, we investigated the predictive power nine polygenic risk scores (PRSs)...
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from GWAS in the largest case-control sample (N = 14,140 cases and N 562,117 controls) to date. We explored genetic architecture of OCD, including its relationships other psychiatric non-psychiatric phenotypes. In analysis, one SNP associated with at significant level. Subsequent...
Major depressive disorder is heritable and a leading cause of disability. Cognitive behavior therapy an effective treatment for major depression. By quantifying genetic risk scores based on common variants, the aim this report was to explore utility psychiatric cognitive trait scores, predicting response 894 adults with therapy. The participants were recruited in setting, primary outcome score measured using Montgomery Åsberg Depression Rating Scale-Self Rated. Single-nucleotide polymorphism...
Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across allele frequency spectrum this heritability remains uncertain. The authors used two new homogeneous cohorts estimate OCD from inherited and contrasted results with those previous studies.The sample consisted 2,090 Swedish-born individuals diagnosed 4,567 control subjects, all genotyped for common variants, specifically >400,000 single-nucleotide polymorphisms...
<b><i>Introduction:</i></b> The operational definitions of treatment response, partial and remission in obsessive-compulsive disorder (OCD) are widely used clinical trials regular practice. However, the clinimetric sensitivity these definitions, that is, whether they identify patients experience meaningful changes their everyday life, remains unexplored. <b><i>Objective:</i></b> objective was to examine children adults with OCD....
Abstract Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology unknown and treatment outcomes could be improved if biological targets identified. Unfortunately, genetic findings for OCD are lagging behind other disorders. Thus, there pressing need to understand the causal mechanisms implicated in order improve clinical reduce morbidity societal costs. Specifically, large‐scale, etiologically informative study integrating environmental factors that...
Abstract Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution OCD large, copy number (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of CNVs called genotype array data in 2,248 deeply phenotyped cases 3,608 unaffected controls Sweden Norway. We found that...
Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped phenotyped individuals with depression or disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose to improve risk stratification, outcome prediction secondary preventive interventions. precision medicine initiative that combines clinical, genetic nationwide register data. Participants...
Abstract Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due significant challenges defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed derive a stringent definition treatment investigate the overlap between MDD. Using electronic medical records on use antidepressants electroconvulsive therapy (ECT) from Swedish registers, we derived phenotype treatment-resistant depression (TRD)...
Abstract Objective Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of common genetic variation across allele frequency spectrum this heritability remains uncertain. We use two new, homogenous cohorts estimate OCD from and contrast results with prior studies. Methods The sample consisted 2096 Swedish-born individuals diagnosed 4609 controls, all genotyped for variants, specifically >400,000 single nucleotide polymorphisms (SNPs) minor...
Abstract Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression anxiety disorders. However, up 50% of patients do not experience sufficient symptom relief. Identifying patient characteristics predictive higher post-treatment severity crucial devising personalized interventions avoid failures reduce healthcare costs. Using the new Swedish multimodal database MULTI-PSYCH, we expand upon established predictors outcome...
Abstract Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due significant challenges defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed derive a stringent definition treatment investigate overlap between MDD. Using electronic medical records on the use antidepressants electroconvulsive therapy (ECT) from Swedish registers, we derived phenotype treatment-resistant depression (TRD)...
Couples with one partner who stutters completed questionnaires about the fluent partners' awareness of their spouses' stuttering; general knowledge how spouses had helped partners; and nature benefits spousal participation in therapy. Findings strongly suggested that may be helpful Considerations suggestions for involving are made on basis these findings those surveys by speech-language pathologists (SLPs) include fluency