A5062707573- Statistical Methods and Inference
- Obesity, Physical Activity, Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Statistical Methods and Bayesian Inference
- Venous Thromboembolism Diagnosis and Management
- Climate Change and Health Impacts
- Physical Activity and Health
- Inflammatory Myopathies and Dermatomyositis
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Nutritional Studies and Diet
- Advanced Statistical Methods and Models
- Advanced Causal Inference Techniques
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Statistical Methods in Clinical Trials
- Neonatal Respiratory Health Research
- Obsessive-Compulsive Spectrum Disorders
- Acute Ischemic Stroke Management
- Pregnancy and preeclampsia studies
- Workplace Health and Well-being
- Noise Effects and Management
Karolinska Institutet
2016-2025
Covance (United States)
2023
CSL (Switzerland)
2023
Center for Rheumatology
2023
Pfizer (United Kingdom)
2023
Novartis (Switzerland)
2023
Octapharma (Austria)
2023
Merck (Germany)
2023
Galapagos (Belgium)
2023
Janssen (Switzerland)
2023
<h3>Objective</h3> To develop and validate new classification criteria for adult juvenile idiopathic inflammatory myopathies (IIM) their major subgroups. <h3>Methods</h3> Candidate variables were assembled from published expert opinion using consensus methodology. Data collected 47 rheumatology, dermatology, neurology paediatric clinics worldwide. Several statistical methods used to derive the criteria. <h3>Results</h3> Based on data 976 IIM patients (74% adults; 26% children) 624 non-IIM...
To develop and validate new classification criteria for adult juvenile idiopathic inflammatory myopathies (IIM) their major subgroups.Candidate variables were assembled from published expert opinion using consensus methodology. Data collected 47 rheumatology, dermatology, neurology, pediatric clinics worldwide. Several statistical methods utilized to derive the criteria.Based on data 976 IIM patients (74% adults; 26% children) 624 non-IIM with mimicking conditions (82% 18% children),...
In longitudinal studies, measurements of the same individuals are taken repeatedly through time. Often, primary goal is to characterize change in response over time and factors that influence change. Factors can affect not only location but also more generally shape distribution To make inference about a population distribution, widely popular mixed-effects regression, for example, would be inadequate, if approximately Gaussian. We propose novel linear model quantile regression (QR) includes...
Background: Prolonged high temperatures and air pollution from wildfires often occur together, the two may interact in their effects on mortality. However, there are few data such possible interactions. Methods: We analyzed day-to-day variations number of deaths Moscow, Russia, relation to levels temperature during disastrous heat wave wildfire 2010. Corresponding for period 2006–2009 were used comparison. Daily average PM10 ozone obtained several continuous measurement stations. The daily...
Background Exposure to arsenic through drinking water has been associated with impaired cognitive function in school-aged children a few cross-sectional studies; however, there is little information on critical windows of exposure. Methods We conducted population-based longitudinal study rural Bangladesh. assessed the association exposure, based urinary (U-As; twice during pregnancy and childhood), development about 1700 at 5 years age using Wechsler Pre-school Primary Scale Intelligence...
The standard two-stage approach for estimating non-linear dose-response curves based on aggregated data typically excludes those studies with less than three exposure groups. We develop the one-stage method as a linear mixed model and present main aspects of methodology, including specification, estimation, testing, prediction, goodness-of-fit, comparison, quantification between-studies heterogeneity. Using both fictitious real from published meta-analysis, we illustrated features proposed...
Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, we evaluated levels phthalates, non-phthalate plasticizers and bisphenols dust from 100 Swedish preschools identified important exposure factors indoor environment. addition, children's total these was determined by urine analysis investigate relation with exposure, explore time trends comparing children who provided fifteen years earlier. The most abundant preschool were...
We followed prospectively 834 consecutive patients (70% inpatients), evaluated for suspected pulmonary embolism, a median time of 2.1 years (range, 0-4.8 yr), and compared the survival rates in with proven embolism (n = 320) those without 514). In multivariate analysis, we modeled probability surviving as function extent vascular obstruction at baseline. Among scintigraphic follow-up was pursued to assess restoration perfusion over 1-year period. found that massive (vascular ≥50%) is risk...
Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited.The aim the present study was to assess effects maternal Cd exposure pregnancy on size at birth.This prospective cohort nested population-based nutritional supplementation trial conducted rural Bangladesh. We selected women recruited February 2002 through January 2003 who had singleton birth with measurements donated urine sample early for analyses (n = 1,616). Urinary...
There is limited knowledge of the prognostic value quantitative computed tomography (CT) measures emphysema and airway wall thickness (AWT) on mortality.To examine 8-year mortality in relation to CT-measured AWT, assess if potential impact these predictors remained after adjustment for lung function.In Norwegian GenKOLS study 2003-2005, 947 ever-smokers (49% with COPD) aged 40-85 years performed spirometry CT examination. Mortality data from 2003-2011 were gathered Cause Death Registry. %...
Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood.We evaluated the associations between cadmium and neurobehavioral development in preschool children.In our population-based mother-child cohort study rural Bangladesh, we assessed 1,305 women early pregnancy their children at 5 years age by measuring concentrations urine (U-Cd), using inductively coupled plasma mass spectrometry. Children's IQ age, including Verbal...
Dietary cadmium exposure was recently found to alter DNA methylation in adults, but data on effects early life are lacking. Our objective evaluate associations between prenatal exposure, and birth weight. In total 127 mother-child pairs from rural Bangladesh were studied. For comparison, we included 56 children at 4.5 y. Cadmium concentrations mothers' blood (gestational week 14) children's urine measured by ICPMS. Global analyzed Infinium HumanMethylation450K BeadChip cord blood. Maternal...
Abstract The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development estrogen-dependent malignancies, such as breast cancer. However, no prospective studies exposure and cancer risk have been reported. We examined association between dietary (at baseline, 1987) overall receptor (ER)–defined (ER+ or ER−) within a population-based cohort 55,987 postmenopausal women. During average 12.2 years follow-up, 2,112 incident cases invasive were...
Background. In suspected acute bacterial meningitis (ABM), cerebral computerized tomography (CT) is recommended before lumbar puncture (LP) if mental impairment. Despite guideline emphasis on early treatment, performing CT prior to LP implies a risk of delayed treatment and unfavorable outcome. Therefore, Swedish guidelines were revised in 2009, deleting impaired status as contraindication for without scan. The aim the present study was evaluate revision. Methods. quality registry...
<h3>Importance</h3> Smoking tobacco is a well-established risk factor for multiple sclerosis (MS), chronic inflammatory disorder of the central nervous system usually characterized by bouts and remissions typically followed secondary progressive (SP) course. However, it not clear whether smoking after diagnosis detrimental. <h3>Objective</h3> To determine MS associated with change in time to SP disease. <h3>Design, Setting, Participants</h3> Cross-sectional study patients prevalent who...
Data on familial recurrence rates of complex diseases such as multiple sclerosis give important hints to aetiological factors the importance genes and environment. By linking national registries, we sought avoid common limitations clinic-based studies low numbers, poor representation population selection bias. Through Swedish Multiple Sclerosis Registry a nationwide hospital registry, total 28 396 patients with were identified. We used Multi-Generation identify first second degree relatives...
Rationale: Long-term exposure to air pollution has been related lung function decrements in children, but the role of timing remains unknown.Objectives: To assess long-term on school-age children.Methods: More than 1,900 children Swedish birth cohort BAMSE were followed with repeated questionnaires, dynamic spirometry, and IgE measurements until 8 years age. Outdoor concentrations particulate matter an aerodynamic diameter less 10 μm (PM10) from road traffic estimated for residential, day...
Objective To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) their major subgroups. Methods An international, multidisciplinary group of myositis experts produced a set 93 potentially relevant variables be tested inclusion in criteria. Rheumatology, dermatology, neurology paediatric clinics worldwide collected data on 976 IIM cases (74% adults, 26% children) 624 non-IIM comparator with mimicking conditions...
Relapse is the main reason for treatment failure in childhood acute lymphoblastic leukemia. Despite improvements up-front therapy, survival after relapse still relatively poor, especially high-risk relapses. The aims of this study were to assess outcomes following leukemia common initial Nordic Society Paediatric Haematology and Oncology protocol treatment; validate currently used risk stratifications, identify additional prognostic factors overall survival. Altogether, 516 2735 patients...
In this prospective cohort study, based on 1,505 mother-infant pairs in rural Bangladesh, we evaluated the associations between early-life exposure to arsenic, cadmium, and lead, assessed via concentrations maternal child urine, children's weights heights up age 5 years, during period 2001-2009. Concurrent prenatal exposures were using linear regression analysis, while longitudinal was mixed-effects regression. An inverse association found weight height, age-adjusted z scores, growth...
<h3>Objectives</h3> To analyse the association between dietary long-chain n-3 polyunsaturated fatty acids (PUFAs) and incidence of rheumatoid arthritis (RA) in middle-aged older women from Swedish Mammography Cohort, a population-based prospective study. <h3>Methods</h3> Data on diet were collected 1987 1997 via self-administered food-frequency questionnaire (FFQ). The risk RA associated with PUFAs fish intake was estimated using Cox proportional hazard regression models, adjusted for age,...