Ignacio García‐De La Torre
A5028240228- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Celiac Disease Research and Management
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diabetes and associated disorders
- Autoimmune Bullous Skin Diseases
- Viral Infections and Immunology Research
- Platelet Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
Universidad de Guadalajara
2015-2024
Secretaría de Salud de Jalisco
2012-2024
Hospital Universitario Ramón y Cajal
2024
Instituto Ramón y Cajal de Investigación Sanitaria
2024
Secretaria de Salud
1995-2023
LUPUS UK
2022
Hospital de Basurto
2018-2022
Karolinska University Hospital
2022
Hospital Civil de Guadalajara
1998-2021
Secretaria de Salud
2020
<h3>Objective</h3> To develop and validate new classification criteria for adult juvenile idiopathic inflammatory myopathies (IIM) their major subgroups. <h3>Methods</h3> Candidate variables were assembled from published expert opinion using consensus methodology. Data collected 47 rheumatology, dermatology, neurology paediatric clinics worldwide. Several statistical methods used to derive the criteria. <h3>Results</h3> Based on data 976 IIM patients (74% adults; 26% children) 624 non-IIM...
To develop and validate new classification criteria for adult juvenile idiopathic inflammatory myopathies (IIM) their major subgroups.Candidate variables were assembled from published expert opinion using consensus methodology. Data collected 47 rheumatology, dermatology, neurology, pediatric clinics worldwide. Several statistical methods utilized to derive the criteria.Based on data 976 IIM patients (74% adults; 26% children) 624 non-IIM with mimicking conditions (82% 18% children),...
Anti-nuclear antibodies (ANA) are fundamental for the diagnosis of autoimmune diseases, and have been determined by indirect immunofluorescence assay (IIFA) decades. As demand ANA testing increased, alternative techniques were developed challenging classic IIFA. These platforms differ in their antigen profiles, sensitivity specificity, raising uncertainties regarding standardisation interpretation incongruent results. Therefore, an international group experts has created recommendations...
Abstract Antinuclear antibodies wer demonstrated in the sera of 43 45 (96%) patients with progressive systemic sclerosis (22 24 diffuse scleroderma and 21 CREST syndrome variant). This high percentage positive reactions resulted from use a tissue culture substrate (Hep‐2) to detect antinuclear by indirect immunofluorescent method. Patterns nuclear staining included fine speckles, large coarse nucleolar centromere staining. When organ sections such as mouse kidney were used for detection...
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals European (EA), African (AA) Hispanic Amerindian (HA) ancestry. identify 58 distinct non-HLA regions in EA, 9 AA 16 HA (∼50% these have multiple independent associations); include 24 novel (P<5 × 10-8), refined signals established regions, extended associations to additional...
The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of antinuclear antibodies (ANA). dichotomous outcome, negative or positive, integrated in diagnostic and classification criteria several systemic autoimmune diseases. However, the IIFA test has much more to offer: besides titre fluorescence intensity, it also provides pattern(s). latter include nucleus cytoplasm interphase as well patterns associated with mitotic cells. International Consensus ANA...
To evaluate the beneficial effect of antimalarial treatment on lupus survival in a large, multiethnic, international longitudinal inception cohort.Socioeconomic and demographic characteristics, clinical manifestations, classification criteria, laboratory findings, variables were examined patients with systemic erythematosus (SLE) from Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL) cohort. The diagnosis SLE, according to American College Rheumatology was assessed within 2...
Objective To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) their major subgroups. Methods An international, multidisciplinary group of myositis experts produced a set 93 potentially relevant variables be tested inclusion in criteria. Rheumatology, dermatology, neurology paediatric clinics worldwide collected data on 976 IIM cases (74% adults, 26% children) 624 non-IIM comparator with mimicking conditions...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with strong genetic component. We undertook the present work to perform first genome-wide association study on individuals from Americas who are enriched for Native American heritage.We analyzed 3,710 US and 4 countries of Latin America were diagnosed as having SLE, healthy controls. Samples genotyped HumanOmni1 BeadChip. Data out-of-study controls HumanOmni2.5 also included. Statistical analyses performed using SNPtest...
The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in indirect immunofluorescence assay HEp-2 cells. One of topics discussed at second ICAP workshop, addressed this paper, harmonization reporting test results. This discussion centered issue if cytoplasmic mitotic should be reported positive or negative. report outlines issues that impact two major different methods....
To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Expert surveys, logistic regression, conjoint analysis were used to 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in where different levels of 2 measures presented. The PAPRIKA (Potentially All Pairwise Rankings Possible Alternatives) method determined the relative weights definitions. performance characteristics evaluated on patient...
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents significant challenge for both diagnosis treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice American patients lupus. Two independent teams (rheumatologists experience management methodologists) had an initial meeting Panama City, Panama, April 2016. They...
The second meeting for the International Consensus on Antinuclear antibody (ANA) Pattern (ICAP) was held 22 September 2015, one day prior to opening of 12th Dresden Symposium Autoantibodies in Dresden, Germany. ultimate goal ICAP is promote harmonization and understanding autoantibody nomenclature, thereby optimizing ANA usage patient care. newly developed website www.ANApatterns.org introduced more than 50 participants. This followed by several presentations discussions focusing key issues...
The establishment of the International Consensus on ANA Patterns (ICAP) in 2014-2015 was welcomed by members medical community as a significant improvement guiding harmonization test interpretation and reporting. In subsequent years, several itinerant meetings continuous interaction with contributed to disseminate ICAP immunofluorescence patterns observed indirect assay HEp-2 cells (HEp-2 IFA) promote progressive classification IFA patterns. 6th Workshop held person September 6, 2021...
Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy manage pandemic. Although none of currently approved vaccines are live-attenuated, several reports disease flares, waning protection, acute-onset syndromes emerged as short-term adverse events after...
American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) a higher prevalence of nephritis than do Caucasians. The aim this study was to analyze the relationship between genetic ancestry sociodemographic characteristics clinical features in large cohort Indian-European SLE patients.A total 2,116 patients origin 4,001 European descent for whom we had data were included study. Genotyping 253 continental ancestry-informative...
Recent reports have associated NCF2, encoding a core component of the multi-protein NADPH oxidase (NADPHO), with systemic lupus erythematosus (SLE) susceptibility in individuals European ancestry. To identify ethnicity-specific and -robust variants within we assessed 145 SNPs around NCF2 gene 5325 cases 21 866 controls European-American (EA), African-American (AA), Hispanic (HS) Korean (KR) Subsequent imputation, conditional, haplotype bioinformatic analyses identified seven potentially...
Objective To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods Expert surveys, logistic regression, conjoint analysis were used to 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in where different levels of 2 measures presented. The PAPRIKA (Potentially All Pairwise Rankings Possible Alternatives) method determined the relative weights definitions. performance characteristics...
The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution reducing poor clinical outcomes, vaccine hesitancy an obstacle achieving high levels uptake. This represents particular risk patients with autoimmune diseases, group already at increased hospitalization outcomes related infection. there is paucity long-term safety efficacy data in current evidence...
Abstract Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain evidence of their safety patients with systemic autoimmune and inflammatory disorders (SAIDs). vaccination-related adverse events (AEs) SAIDs controls (HC) seven days post-vaccination were assessed COVAD study, a patient self-reported cross-sectional survey. Methods The survey was circulated early 2021 by &gt;110 collaborators (94 countries) collect SAID details, vaccination...
Abstract Objectives Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There many variables influencing IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on testing that offer novel features adopted some clinical laboratories include automated...