Jessica Day
A5070801160- Inflammatory Myopathies and Dermatomyositis
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Peripheral Neuropathies and Disorders
- Parkinson's Disease and Spinal Disorders
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Muscle and Compartmental Disorders
- Immunodeficiency and Autoimmune Disorders
- Muscle Physiology and Disorders
- Viral Infections and Immunology Research
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Microbial infections and disease research
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders Research
- Myasthenia Gravis and Thymoma
- Celiac Disease Research and Management
- Autoimmune Bullous Skin Diseases
- Dermatological and COVID-19 studies
- Chronic Disease Management Strategies
The Royal Melbourne Hospital
2013-2025
Walter and Eliza Hall Institute of Medical Research
2021-2025
The University of Melbourne
2017-2025
Inova Fairfax Hospital
2024
University Medical Center
2024
University Hospital and Clinics
2024
Tulane University
2024
Louisiana State University
2024
Florida State University
2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
BackgroundMycoplasma pneumoniae respiratory infections are transmitted by aerosol and droplets in close contact.AimWe investigated global M. incidence after implementation of non-pharmaceutical interventions (NPIs) against COVID-19 March 2020.MethodsWe surveyed detections from laboratories surveillance systems (national or regional) across the world 1 April 2020 to 31 2021 compared them with cases corresponding months between 2017 2020. Macrolide-resistant (MRMp) data were collected...
Muscle cell death in polymyositis is induced by CD8+ cytotoxic T lymphocytes. We hypothesized that the injured muscle fibers release pro-inflammatory molecules, which would further accelerate lymphocytes-induced injury, and inhibition of could be a novel therapeutic strategy to suppress both injury inflammation polymyositis. Here, we show pattern FAS ligand-dependent necroptosis, while satellite cells myoblasts perforin 1/granzyme B-dependent apoptosis, using human biopsy specimens patients...
Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy manage pandemic. Although none of currently approved vaccines are live-attenuated, several reports disease flares, waning protection, acute-onset syndromes emerged as short-term adverse events after...
Abstract Introduction/Aims In this study we investigated COVID‐19 vaccination–related adverse events (ADEs) 7 days postvaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune disorders (SAIDs). Methods Seven‐day vaccine ADEs were collected an international patient self‐reported e‐survey. Descriptive statistics obtained multivariable regression was performed. Results Ten thousand nine hundred respondents analyzed (1227 IIM cases, 4640 SAID 5033...
Abstract Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain evidence of their safety patients with systemic autoimmune and inflammatory disorders (SAIDs). vaccination-related adverse events (AEs) SAIDs controls (HC) seven days post-vaccination were assessed COVAD study, a patient self-reported cross-sectional survey. Methods The survey was circulated early 2021 by >110 collaborators (94 countries) collect SAID details, vaccination...
COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for IIMs, other AIRDs, non-rheumatic (nrAIDs) healthy controls (HCs), using data from two international Vaccination Autoimmune Diseases (COVAD) e-surveys.The first second COVAD patient self-reported e-surveys were...
Abstract Objective Flares of autoimmune rheumatic diseases (AIRDs) following COVID-19 vaccination are a particular concern in vaccine-hesitant individuals. Therefore, we investigated the incidence, predictors and patterns flares individuals living with AIRDs, using global Vaccination Autoimmune Diseases (COVAD) surveys. Methods The COVAD surveys were used to extract data on flare demographics, comorbidities, history, details for patients AIRDs. identified as patient-reported (a), increased...
To determine the frequency, clinical correlates and implications of evidence muscle disease in systemic sclerosis (SSc). Australian Scleroderma Cohort Study participants with ≥1 creatine kinase (CK) proximal power assessment were subdivided according to presence weakness (PW: power<5/5) CK elevation(≥140IU/L). Participants assigned one four groups: concurrent PW&CK elevation, PW alone, elevation alone or neither. Between-group comparisons made chi-squared, ANOVA Kruskal-Wallis tests....
Abstract Objectives To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared those non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic (nrAIDs) and without (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination disease (COVAD-2) e-survey database. Methods Demographics, diagnosis, comorbidities, activity, treatments PROMIS were analysed....
The deleterious consequences of chronic synovitis on cartilage, tendon and bone in rheumatoid arthritis (RA) are well-described. In contrast, its effects periarticular skeletal muscle under-studied. Further, while TNF inhibition is an effective therapy for RA synovitis, it exacerbates fibrosis injury models. We aimed to investigate whether myositis features inflammatory evaluate targeted therapies influence these disease features. Periarticular was analysed murine models poly- mono-articular...
Abstract Objectives The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term vaccination-related adverse events (AEs) RA patients. Methods An online self-reported questionnaire (March–December 2021) was used capture data related AEs RA, other rheumatic (AIRDs) (excluding and inflammatory myositis), non-rheumatic (nrAIDs) healthy controls (HCs). Descriptive multivariable regression analyses were performed. Results Of the 9462 complete respondents, 14.2% (n =...
MLKL and RIPK3 are the core signaling proteins of inflammatory cell death pathway, necroptosis, which is a known mediator modifier human disease. Necroptosis has been implicated in progression disease almost every physiological system recent reports suggest role for necroptosis aging. Here, we present first comprehensive analysis age-related histopathological immunological phenotypes cohort Mlkl-/- Ripk3-/- mice on congenic C57BL/6 J genetic background. We show that deletion Mlkl female...
This study assesses the burden, distribution, and evolution of muscle inflammation damage on MRI among subtypes idiopathic inflammatory myopathy (IIM).Musculoskeletal MRIs performed in 66 patients with IIM 10 non-IIM between 2009 2016 were retrospectively graded for edema, fatty replacement (FR), atrophy.Immune-mediated necrotizing (IMNM) had severe extensive lower limb FR, atrophy. The pelvic muscles adductors significantly more affected than dermatomyositis polymyositis. Inclusion body...
Abstract Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire’s disease, form severe community-acquired pneumonia. Infection can have high morbidity, with proportion patients requiring ICU admission, and up to 10% mortality, which exacerbated by lack efficacy typical empirical antibiotic therapy against spp. The fastidious nature entire Legionellaceae family historically required inclusion activated charcoal in solid medium remove growth inhibitors,...
Abstract Objectives Disease flares in the post–coronavirus disease 2019 (COVID-19) vaccination period represent a prominent concern, though risk factors are poorly understood. We studied these among patients with idiopathic inflammatory myopathies (IIMs) and other autoimmune rheumatic diseases (AIRDs). Methods The COVAD-1 -2 global surveys were circulated early 2021 2022, respectively, we captured demographics, comorbidities, AIRDs details, COVID-19 infection history details. Flares of IIMs...