Ran Nir‐Paz
A5036534146- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Listeria monocytogenes in Food Safety
- Antibiotic Resistance in Bacteria
- Cancer Research and Treatments
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Bacterial Infections and Vaccines
- Antibiotics Pharmacokinetics and Efficacy
- Biomedical Ethics and Regulation
- Antibiotic Use and Resistance
- Herpesvirus Infections and Treatments
- Olfactory and Sensory Function Studies
- Vibrio bacteria research studies
- Hepatitis B Virus Studies
- Infection Control and Ventilation
Hadassah Medical Center
2015-2024
Hebrew University of Jerusalem
2009-2024
Comer Children's Hospital
2023
European Society of Clinical Microbiology and Infectious Diseases
2023
Institut de Recherche Vaccinale
2022
University Medical Center
2003-2021
Active Implants (United States)
2019
Israel Ministry of Health
2015
University of California, Berkeley
2005-2011
Sidney Kimmel Cancer Center
2011
Abstract Purpose: Listeria monocytogenes (Lm)-based vaccines stimulate both innate and adaptive immunity. ANZ-100 is a live-attenuated Lm strain (Lm ΔactA/ΔinlB). Uptake by phagocytes in the liver results local inflammatory responses activation recruitment of natural killer (NK) T cells, association with increased survival mice bearing hepatic metastases. The ΔactA/ΔinlB strain, engineered to express human mesothelin (CRS-207), tumor-associated antigen expressed variety tumors, induces...
Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I receptor transgenic cells specific for an ovalbumin (OVA) peptide, IL-1 results in increase the numbers wild-type but not IL1R1−/− cells, particularly spleen, liver, and lung, upon immunization with OVA lipopolysaccharide. administration also enhancement frequency antigen-specific are granzyme B+, have cytotoxic activity, and/ or produce interferon γ (IFN-γ). Cells...
A patient with a trauma-related left tibial infection associated extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated bacteriophages antibiotics. There rapid tissue healing positive culture eradication. As result, the patient's leg did not have to be amputated he is undergoing rehabilitation.
Mycoplasma pneumoniae is a common cause of respiratory tract infections with community-acquired pneumonia as the major disease-related burden. Compared other pathogens, M atypical in many ways: it one smallest self-replicating organisms, has reduced and highly stable genome (0·8 Mbp), lacks cell wall, grows slowly (generation time 6 h), requires close contact for transmission, distinct disease presentation (atypical pneumonia), pathogenesis which might involve host cell-mediated...
BackgroundMycoplasma pneumoniae respiratory infections are transmitted by aerosol and droplets in close contact.AimWe investigated global M. incidence after implementation of non-pharmaceutical interventions (NPIs) against COVID-19 March 2020.MethodsWe surveyed detections from laboratories surveillance systems (national or regional) across the world 1 April 2020 to 31 2021 compared them with cases corresponding months between 2017 2020. Macrolide-resistant (MRMp) data were collected...
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
ObjectivesTo characterize longitudinal symptoms of mild coronavirus disease 2019 (COVID-19) patients for a period 6 months, to potentially aid in management.MethodsPhone interviews were conducted with 103 COVID-19 Israel over 6-month (April 2020 October 2020). Patients recruited via social media and word mouth interviewed up 4 times, depending on reports their unresolved symptoms. Inclusion criteria required participants be residents aged 18 years or older, positive real-time PCR results...
<h3>Importance</h3> Despite the high 3-dose vaccination rate among health care workers (HCWs) in Israel, a of SARS-CoV-2 breakthrough infections this group was observed during Omicron wave. As result, Israeli Ministry Health decided to recommend fourth vaccine dose medical staff. <h3>Objective</h3> To evaluate benefit BNT162b2 on infection HCWs. <h3>Design, Setting, and Participants</h3> This multicenter cohort study performed January 2022, first month 4-dose campaign, surge variant All at...
The use of bacteriophages (phages) is reemerging as a potential treatment option for antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses that may serve personalized therapeutic with minimal collateral damage to the patient microbiome. In 2018 we established Israeli Phage Therapy Center (IPTC) shared initiative Hadassah Medical and Hebrew University Jerusalem, aiming conduct all steps required phage-based solutions, from phage isolation...
ABSTRACT Left ventricular assist devices (LVAD) are increasingly used for management of heart failure; infection remains a frequent complication. Phage therapy has been successful in variety antibiotic refractory infections and is interest treating LVAD infections. We performed retrospective review four patients that underwent five separate courses intravenous (IV) phage with concomitant treatment endovascular Pseudomonas aeruginosa infection. assessed susceptibility, bacterial strain...
Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or preterm delivery, the neonate prone to neonatal sepsis death.We created cohort of all L. cases during 10 years (1998-2007) Israel, by comprehensive review hospitals throughout country reported Ministry Health.One hundred sixty-six pregnancy-related listeriosis were identified, resulting yearly incidence 5-25 per 100...
Macrolide resistance in Mycoplasma pneumoniae is often found Asia but rare elsewhere. We report the emergence of macrolide-resistant M. Israel and vivo evolution such during treatment a 6-year-old boy with pneumonia.
Objective Stripping of the membranes is an established and widely utilized obstetric procedure associated with higher spontaneous vaginal delivery rates, reduced need for formal induction labor a lower likelihood post-term pregnancy. Due to theoretical concern bacterial seeding during many practitioners choose not sweep in Group B Streptococcus (GBS) colonized patients. We conducted 'the STRIP-G study' order determine whether maternal neonatal outcomes are affected by GBS carrier status...
Background Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, with large epidemics previously described to occur every 4 7 years. Aim To better understand the diagnostic methods used detect M . ; M. testing and surveillance in use; identify epidemics; determine detection number per age group, demographics for positive detections, concurrence annual peaks across geographical areas; effect location on timing epidemics. Methods A questionnaire was sent May 2016 experts...