Takeshi Saraya
A5018133311- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Microbial infections and disease research
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Disorders and Syndromes
- Lung Cancer Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Respiratory and Cough-Related Research
- Infectious Diseases and Tuberculosis
- IL-33, ST2, and ILC Pathways
- Congenital Diaphragmatic Hernia Studies
- Inflammatory Myopathies and Dermatomyositis
- Fungal Infections and Studies
- Mycobacterium research and diagnosis
- Phonocardiography and Auscultation Techniques
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
Kyorin University
2016-2025
Weatherford College
2024
Comer Children's Hospital
2023
Fukujuji Hospital
2022
Kyorin University Hospital
2014-2020
Chinese Academy of Sciences
2019
Advantest (Singapore)
2019
École Polytechnique Fédérale de Lausanne
2019
The University of Tokyo
2019
Georgia Institute of Technology
2019
Mycoplasma pneumoniae is a common cause of respiratory tract infections with community-acquired pneumonia as the major disease-related burden. Compared other pathogens, M atypical in many ways: it one smallest self-replicating organisms, has reduced and highly stable genome (0·8 Mbp), lacks cell wall, grows slowly (generation time 6 h), requires close contact for transmission, distinct disease presentation (atypical pneumonia), pathogenesis which might involve host cell-mediated...
To identify initial predictors of poor survival in patients with PM/DM-associated interstitial lung disease (ILD).We established a multicentre retrospective cohort incident cases ILD from 44 institutions across Japan (Multicentre Retrospective Cohort Japanese Patients Myositis-associated ILD, JAMI). Inclusion criteria were an onset age ⩾16 years; PM/DM or clinically amyopathic DM according to the published criteria; imaging evidence ILD; and availability serum samples for assays...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of disease 2019 (COVID-19), is an enveloped, single-stranded RNA virus. Favipiravir orally administrable antiviral drug whose mechanism action to selectively inhibit RNA-dependent polymerase. A preliminary trial in COVID-19 patients reported significant improvements across a multitude clinical parameters, but these findings have not been confirmed adequate well-controlled trial. We conducted randomized, single-blind,...
Abstract Capsid protein of norovirus genogroup II (GII) plays crucial roles in host infection. Although studies on capsid gene evolution have been conducted for a few genotypes norovirus, the molecular GII is not well understood. Here we report all genotypes, using various bioinformatics techniques. The time-scaled phylogenetic tree showed that present strains diverged from GIV around 1630CE at high evolutionary rate (around 10 −3 substitutions/site/year), resulting three lineages. had large...
Secondary pulmonary alveolar proteinosis (sPAP) is a very rare lung disorder comprising approximately 10% of cases acquired PAP. Hematological disorders are the most common underlying conditions sPAP, which 74% demonstrate myelodysplastic syndrome (MDS). However, impact sPAP on prognosis MDS remains unknown. The purpose this study was to evaluate whether development worsens MDS. Thirty-one and were retrospectively classified into mild severe consisting low-/low-risk groups...
Background/Objectives: Bronchoscopy is an invasive procedure, and patient coughing during the examination has been reported to cause significant distress. This study aimed identify predictors of severity assess its impact on procedure bronchoalveolar lavage (BAL) transbronchial lung biopsy (TBLB). Methods: We conducted a prospective involving 119 consecutive patients with diffuse disease who underwent BAL TBLB at Kyorin University Hospital from April 2019 December 2023. Cough was scored...
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society Chemotherapy, Association for Infectious Diseases and Clinical Microbiology 2010.The isolates were collected clinical specimens obtained well-diagnosed adult with tract infections during the period January April 2010 three societies. Antimicrobial testing at central reference laboratory according to method recommended Laboratory Standard...
Background Pleural separation, the "split pleura" sign, has been reported in patients with empyema. However, diagnostic yield of split pleura sign for complicated parapneumonic effusion (CPPE)/empyema and its utility differentiating CPPE/empyema from (PPE) remains unclear. This differentiation is important because need thoracic drainage. In this regard, aim study was to develop a simple method distinguish PPE using computed tomography (CT) focusing on fluid attenuation values (HU: Hounsfield...
Recent reports have suggested an involvement of neutrophilic inflammation driven by interleukin (IL)-17 from Th17 cells, especially in severe, refractory asthma. It remains unknown about the possible interactions this cytokine and other proinflammatory cytokines to direct airway inflammation.We evaluated effects IL-17A, IL-17E, IL-17F combination with stimuli such as tumor necrosis factor (TNF) -α on production expression IL-8 human bronchial epithelial cells. We also studied their...
Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 stable asthmatics are predictor for exacerbation within short duration. This prospective observational study evaluated the 104 asthmatic patients who were treated by disease specialist follow-ups 3 months. High (> 18 ng/ml) predicted severe asthma correlated positively severity (treatment step),...
A 45-year-old man with allergic bronchopulmonary aspergillosis (ABPA) was treated oral prednisolone (PSL) (30 mg/day), inhaled corticosteroids, and long-acting beta2-agonists. After confirmation of a PSL-dependent status (8 subcutaneous injection anti-interleukin (IL)-5 antibody (mepolizumab, 100 mg/month) performed, the PSL dose tapered to 5 mg/day. However, ABPA recurred proved refractory itraconazole (200 mg/day). Alternative therapy dupilumab (induction 600 mg followed by maintenance 300...
Context: In management of community-acquired pneumonia (CAP), excellent biomarkers for inflammation would be helpful in our practice.Objectives: Kinetics c-reactive protein (CRP) and serum amyloid A (SAA) was characterized, using their biologic half-life times.Materials methods: Time course CRP SAA levels the successfully treated 36 CAP patients were investigated times determined compared.Results & Discussions: declined an exponential mean 34.9 ± 28.7 h, significantly shorter than that CRP,...
Abstract We studied the molecular evolution of haemagglutinin ( H ) gene (full length) in all genotypes (24 genotypes, 297 strains) measles virus (MeV). The gene’s evolutionary timescale was estimated by Bayesian Markov chain Monte Carlo (MCMC) method. also analysed positive selection sites. MCMC tree indicated that MeV diverged from rinderpest (same genus) about 250 years ago and 24 formed 3 lineages dating back to a 1915 ancestor (95% highest posterior density [HPD] 1882–1941) with...