A5084369090- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Systemic Sclerosis and Related Diseases
- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Salivary Gland Disorders and Functions
- Inflammatory Myopathies and Dermatomyositis
- Occupational exposure and asthma
- T-cell and B-cell Immunology
- Lung Cancer Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Sarcoidosis and Beryllium Toxicity Research
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
- Systemic Lupus Erythematosus Research
- Occupational and environmental lung diseases
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
Kanagawa Cardiovascular and Respiratory Center
2016-2025
Yokohama City University
1992-2021
National Institute of Infectious Diseases
2021
Nihon University
2016-2020
Toshima Hospital
2020
Respiratory Clinical Trials
2017
University of Shizuoka
2011
Tottori University
2002
Health First
1999
United States Food and Drug Administration
1995-1998
To compare the phenotype and frequency of cells that actively secrete type 1 2 cytokines in systemic lupus erythematosus (SLE) patients (n = 46), versus normal controls 60).ELISPOT analysis freshly isolated peripheral blood mononuclear (PBMC).T were major source interleukin-2 (IL-2), IL-4, interferon gamma (IFN gamma), whereas monocytes primary IL-6 IL-10 PB patients. Significantly fewer PBMC spontaneously secreted IFN IL-2 (P > or 0.03), while significantly more produced < 0.001), controls....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of disease 2019 (COVID-19), is an enveloped, single-stranded RNA virus. Favipiravir orally administrable antiviral drug whose mechanism action to selectively inhibit RNA-dependent polymerase. A preliminary trial in COVID-19 patients reported significant improvements across a multitude clinical parameters, but these findings have not been confirmed adequate well-controlled trial. We conducted randomized, single-blind,...
Abstract The mechanism of immune activation induced by a plasmid-encoding GM-CSF (pGM-CSF), administered in combination with DNA vaccine encoding the envelope HIV, was studied. Injecting pGM-CSF i.m. into mice 3 days before vaccination primarily Th2 response. Simultaneous administration plus activated both Th1 and When plasmid injected after vaccination, enhancement immunity predominated. These results suggest that timing cytokine expression determines phenotype resultant Th After injection,...
The number, type, and location of cytokine- Ab-secreting cells activated in mice immunized boosted with plasmid DNA encoding the circumsporozoite protein malarial parasite Plasmodium yoelii (PyCSP) were monitored. initial humoral response was localized to draining lymph nodes characterized by production IgG1 anti-PyCSP Abs Th2 cytokine IL-4. In contrast, secondary dominated IFN-gamma (a Th1 cytokine) secretion IgG2a spleen. PyCSP mRNA detected only quadriceps muscles (sites injection), yet...
Introduction Interstitial lung disease associated with primary Sjögren’s syndrome (pSS–ILD) shows several patterns such as nonspecific interstitial pneumonia (NSIP) and usual (UIP). Although UIP is a well–recognized prognostic determinant in idiopathic pneumonias, whether this also the case pSS–ILD unclear. The objectives of study were to evaluate effect UIP, identify factors pSS–ILD. Methods A retrospective review medical records identified 33 consecutive patients pathologically–proven Each...
Abstract Background and objective Myeloperoxidase anti‐neutrophil cytoplasmic antibody (MPO‐ANCA) is occasionally positive in patients with usual interstitial pneumonia (UIP). However, the differences from idiopathic pulmonary fibrosis (IPF/UIP) have not been well documented. We aimed to clarify clinical, radiological pathological features of UIP associated MPO‐ANCA (ANCA/UIP). Methods retrospectively reviewed medical records 12 consecutive ANCA/UIP manifesting microscopic polyangiitis 108...
Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue (MCTD). The heterogeneous, its outcome unpredictable. Some patients have severe progressive deterioration ILD, which the leading cause mortality. We aimed to determine whether serum levels Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity.We retrospectively analyzed medical records 40 ILD: 29 SSc 11 MCTD. Measurement KL-6...
The COVID-19 pandemic is an unprecedented threat to humanity that has provoked global health concerns. Since the etiopathogenesis of this illness not fully characterized, prognostic factors enabling treatment decisions have been well documented. Accurately predicting progression disease would aid in appropriate patient categorization and thus help determine best option. Here, we introduced a proteomic approach utilizing data-independent acquisition mass spectrometry (DIA-MS) identify serum...
RanBPM is a RanGTP-binding protein required for correct nucleation of microtubules. To characterize the mechanism, we searched RanBPM-binding proteins by using yeast two-hybrid method and isolated cDNA encoding ubiquitin-specific protease USP11. The full-length USP11 was cloned from Jurkat cell library. Sequencing revealed that possesses Cys box, His Asp KRF domains, which are highly conserved in many proteases. By immunoblotting HeLa cells, concluded 921-residue version predominant form,...
Little has been reported on long-term pulmonary function trends among patients with interstitial lung disease associated anti-aminoacyl-tRNA synthetase antibodies (ARS-ILD).To clarify the factors predictive of progression in ARS-ILD based patients' initial clinical and radiological features.The courses 88 > 1 year follow-up data tests (PFTs) were retrospectively analyzed. Disease behavior was categorized into three groups: (1) improved or (2) worsened (defined as increases decreases,...
To assess the relationships among pulmonary vascular enlargement, computed tomography (CT) findings quantified with software, and coronavirus disease (COVID-19) severity.Ultra-high-resolution (UHR) CT images of 87 patients (50 males, 37 females; median age, 63 years) COVID-19 confirmed using real-time polymerase chain reaction were analyzed. The maximum subsegmental diameter was measured on CT. Total lung volume (CTLV total) lesion extent (ratio to CTLV ground-glass opacities, reticulation,...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
<title>Abstract</title> Backgrounds: Several guidelines have recently indicated amikacin liposome inhalation suspension (ALIS) as a new treatment option for refractory <italic>Mycobacterium avium</italic> complex pulmonary disease (MAC-PD). There are few reports on the efficacy of ALIS in clinical settings. We investigated adverse events and outcomes patients who were treated with at our hospital. Methods The subjects 20 MAC-PD observed over six months after introduction hospital from August...
The catalytic residues of levansucrase (sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase, EC 2.4.1.10) from Zymomonas mobilis were analyzed by random mutation and site-directed mutagenesis. We found that substitution Glu278 with Asp His reduced the k(cat) for sucrose hydrolysis 30- 210-fold, respectively, strongly suggesting plays a key role in catalyzing this reaction. Given likelihood another acidic amino residue was also involved, we constructed variants which acids located within...
The different characteristics of usual interstitial pneumonia in patients with primary Sjögren׳s syndrome (UIP/pSS) compared idiopathic pulmonary fibrosis (UIP/IPF) are not fully understood. This study aimed to compare characteristics, prognosis, and treatment responses these patients. Among 129 consecutive who underwent surgical lung biopsy diagnose diffuse diseases at Kanagawa Cardiovascular Respiratory Center between 1998 2002, we identified 10 19 UIP/pSS UIP/IPF, respectively. Baseline...
Anti-glycyl-tRNA synthetase (anti-EJ) antibody is occasionally positive in patients with interstitial lung disease (ILD). We aimed to define the clinical, radiological and pathological features of anti-EJ antibody-positive ILD (EJ-ILD). retrospectively analyzed medical records 12 consecutive EJ-ILD who underwent surgical biopsy. The median follow-up time was 74 months (range, 17–115 months). age 62 years 47–75 years). Seven were female. Eight presented acute onset. Six eventually developed...