A5102999110- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Inflammatory Myopathies and Dermatomyositis
- Tuberculosis Research and Epidemiology
- Head and Neck Cancer Studies
- Sarcoidosis and Beryllium Toxicity Research
- Pneumocystis jirovecii pneumonia detection and treatment
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Mycobacterium research and diagnosis
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Pleural and Pulmonary Diseases
- Antifungal resistance and susceptibility
- Quinazolinone synthesis and applications
- Dermatological and COVID-19 studies
- Hypertrophic osteoarthropathy and related conditions
- Dermatological and Skeletal Disorders
- Urinary and Genital Oncology Studies
- Cancer Research and Treatments
- Eosinophilic Disorders and Syndromes
- Immune Response and Inflammation
The Jikei University Hospital
2016-2024
Kanagawa Cardiovascular and Respiratory Center
2016-2018
Kobe Medical Center
2005
Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue (MCTD). The heterogeneous, its outcome unpredictable. Some patients have severe progressive deterioration ILD, which the leading cause mortality. We aimed to determine whether serum levels Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity.We retrospectively analyzed medical records 40 ILD: 29 SSc 11 MCTD. Measurement KL-6...
The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative results. extent TB spread may influence host immune functions, which can results test. few previous reports have investigated association between radiologic pulmonary (PTB) severity and test We retrospectively patients with culture-confirmed at Jikei University Daisan Hospital September 2016 December 2021. aimed to clarify PTB severity, according computed...
After the commercialization of nintedanib in Japan, a high incidence hepatotoxicity resulting treatment interruption was noted idiopathic pulmonary fibrosis (IPF) patients treated with our hospital. This study aimed to clarify risk factors for nintedanib. Sixty-eight consecutive cases IPF newly at dose 150 mg twice daily from September 2015 2016 were enrolled: 46 (67.6%) exhibited aspartate aminotransferase (AST) and/or alanine (ALT) elevation and 16 (23.5%) also had Common Terminology...
Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD.This study was conducted to elucidate characteristics, prognosis, behavior in patients lung (ILD) associated systemic sclerosis (SSc)-related autoantibodies.We retrospectively analyzed medical records 72 ILD patients: 40 SSc (SSc-ILD) 32 SSc-related autoantibody-positive but CTD (ScAb-ILD), indicating...
Pulmonary emphysema combined with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) occurs more often in smokers but also never-smokers. This study aimed to describe a new finding characterized by peculiar emphysematous change SSc-associated ILD (SSc-ILD).We conducted retrospective review of 21 consecutive patients SSc-ILD diagnosed surgical biopsy and focused on the radio-pathological correlation change.Pathological pulmonary (p-PE) was predominant complication 16 (76.2%)...
Abstract We report a case of infective endocarditis (IE) due to nasal septal perforation during Home oxygen therapy (HOT). A 64‐year‐old man with history interstitial pneumonia (IP) and on HOT was hospitalized for dyspnea. Methicillin‐sensitive Staphylococcus aureus (MSSA) repeatedly detected in blood cultures. Echocardiography revealed tricuspid valve vegetation regurgitation. The patient diagnosed IE, according the modified Duke criteria. full‐body examination MSSA isolated from cavity....
As an idiopathic interstitial pneumonia, desquamative pneumonia (DIP) is uncommon form of lung disease and considered to be a smoking- or dust inhalation-related in the majority cases. However, details regarding immunoglobulin G4 (IgG4)-related remain unclear controversial. We herein report first case DIP complicated with IgG4-related disease. Even if patient has smoking history, we emphasize importance exploring association between clarify pathogenesis these two disorders.
Some forms of idiopathic retroperitoneal fibrosis (RF) have recently been considered to be a part the spectrum immunoglobulin G4 (IgG4)-related disease. This case report is first description spontaneous remission in patient with pathologically proven IgG4-related RF. Although pathogenesis and long-term disease behavior RF remains unknown, we believe that an initial assessment consisting only careful monitoring might one important strategy, especially asymptomatic patients without...
We report an 80-year-old woman with EGFR-mutant lung adenocarcinoma multiple brain metastases (BMs). All lesions including BM showed a successful resolution after initiating daily 150 mg erlotinib. However, grade 2 bilirubin-increase developed, and it was necessary to reduce the dose of erlotinib 50 every other day, which aggravated BM. Switching afatinib led without increase in bilirubin level. Our results indicate that is important treatment option when erlotinib-induced hepatotoxicity...
Key Clinical Message Organizing pneumonia (OP) and pulmonary alveolar proteinosis (PAP) are rare complications in patients with hematologic disorders. We herein report a case of PAP that developed during steroid treatment for OP patient atypical chronic myeloid leukemia. Physicians should pay close attention to these malignancies.
Chronic obstructive pulmonary disease (COPD) is a major comorbid of Mycobacterium avium complex (MAC-PD). Emphysema one the main pathological findings in COPD, risk factor for chronic aspergillosis (CPA), and associated with poor prognosis. We aimed to clarify effect emphysema on mortality MAC-PD.We retrospectively analyzed 203 patients MAC-PD at The Jikei Daisan Hospital between January 2014 December 2018. investigated CPA development rates after diagnosis or without emphysema.Multivariate...
Abstract Background Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies investigated smoking-associated lung diseases. Emphysema is major pathological finding smoking-related damage. We aimed to clarify effect emphysema sputum culture conversion rate for Mycobacterium (MTB). Methods retrospectively studied 79 male patients with PTB confirmed by acid-fast bacillus smear and at Jikei University Daisan Hospital between...
Coronavirus disease 2019 (COVID-19) pneumonia can have prolonged sequelae and lead to respiratory dysfunction, mainly because of impaired diffusion capacity for carbon monoxide (DLCO). The clinical factors associated with DLCO impairment, including blood biochemistry test parameters, remain unclear.Patients COVID-19 who underwent inpatient treatment between April 2020 August 2021 were included in this study. A pulmonary function was performed 3 months after onset, the symptoms investigated....
It is unknown whether tyrosine kinase inhibitors targeting epidermal growth factor receptor (EGFR) can be discontinued in patients whom
Abstract Background The T-SPOT. TB assay is widely used in adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative results. extent spread may influence host immune function, which can results the . few previous reports have investigated association between radiologic pulmonary (PTB) severity and Methods We retrospectively patients with culture-confirmed at Jikei University Daisan Hospital September 2016 December 2021. aimed to clarify PTB severity,...
The reversed halo sign was initially reported as a representative computed tomography scan finding of cryptogenic organizing pneumonia. Since then, however, it has been in various diseases and is now considered nonspecific finding. However, there are no cases humidifier lung with the sign. An 82-year-old Japanese male patient presented moving difficulties 48 days after starting darolutamide treatment for prostate cancer. He admitted to hospital due acute pneumonia, which bilateral extensive...
Interstitial pneumonia is a common and major comorbidity affecting the prognosis of patients with systemic sclerosis (SSc). However, there are few reported cases SSc-rheumatoid arthritis (RA) overlap-associated interstitial pneumonia. We herein report case in which clinical behavior histopathology SSc-RA overlap syndrome was followed over long course. When clinicians deciding on treatment strategy for syndrome-associated pneumonia, pathological examination surgical lung biopsy may be useful.
背景．G-CSF産生肺癌は予後不良であることが知られている．症例．症例1は68歳，男性．血痰と右肩痛で受診し，精査の結果非小細胞肺癌cT3N0M1b（OSS）stage IVと診断し，全身化学療法を行うも奏効せず，3か月で永眠した．症例2は64歳，男性．健診胸部異常陰影で受診，EGFR遺伝子変異陰性の低分化肺腺癌cT3N0M0 stage IIBと診断し，腫瘍切除後に化学療法を行うも7か月で永眠した．いずれも白血球増多，血清G-CSF高値，免疫組織学的G-CSF陽性を認めた．結論．G-CSF産生肺癌は腫瘍の浸潤と増大が速く臨床上留意すべきであり，さらなる臨床症例の集積および基礎研究の発展による治療法確立が望まれる．
We report a case of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) seroconversion with interstitial pneumonia that developed in 67-year-old Japanese man. Radiological findings included reticular shadow and cystic change along increased attenuation the lower lung. Histological revealed patchy dense fibrosis accentuated peripheral zones corresponding to usual pattern marked inflammatory cell infiltration change, which indicated unclassifiable pneumonia. Although there was no...