A5016693708- Tuberculosis Research and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Antifungal resistance and susceptibility
- Lung Cancer Treatments and Mutations
- Sarcoidosis and Beryllium Toxicity Research
- Myasthenia Gravis and Thymoma
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Nail Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Inflammatory Myopathies and Dermatomyositis
- Colorectal Cancer Treatments and Studies
- Fungal Infections and Studies
- Emergency and Acute Care Studies
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cellular transport and secretion
- Drug-Induced Hepatotoxicity and Protection
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
Akita Prefectural University
2025
Tokyo National Hospital
2024
Saitama Prefecture
2016-2020
The Jikei University Hospital
2015-2020
SummaryPrevious studies have suggested that chromogranin A (CgA) is a partner molecule of secretogranin III (SgIII). In mouse pituitary corticotroph-derived AtT-20 cells, SgIII plays role in sorting CgA/hormone aggregates into secretory granules (SGs). Although CgA expression equivocal, CgB clearly detectable the rat corticotrophs. Therefore, we hypothesized shares function with binding assays, CgB, similar to CgA, showed activity under weakly acidic conditions and presence Ca
Relapse of cryptogenic organizing pneumonia (COP) may lead to poor long-term prognosis and necessitates multiple rounds steroid treatment with potential adverse effects. The objective this study is identify predictive factors COP relapse by comparing demographic clinical variables between non-relapse groups.During 2008-2013, 33 patients were treated, which 23 (69.7%) 10 (30.3%) assigned the group, respectively. From medical records, we compared following at initial episode: characteristics,...
The effectiveness of hepatoprotective drugs for DIH (drug induced hepatotoxicity) during tuberculosis treatment is not clear. We evaluated the by comparing period until normalization hepatic enzymes between patients who were prescribed with after was occurred and drugs.During 2006-2010, 389 active included in this study. defined as elevation peak serum aspartate aminotransferase (AST) and/or alanine (ALT) more than twice upper limit normal (ULN). divided into severe (peak AST ALT >5 times...
The incidence and etiologies of chronic pulmonary infection (CPI) in patients with idiopathic fibrosis (IPF) have been poorly investigated.We conducted a retrospective study 659 IPF to assess the incidence, etiologies, risk factors CPI development. was defined if etiology diagnosed one or more months after onset symptoms upon appearance new shadows on radiological images.At diagnosis, 36 (5.5%) had CPI, 46 (7.0%) without at diagnosis developed over median follow-up period 6.1 years. density...
A 58-year-old man presented with right chest pain, anorexia, general malaise, and fever. Chest computed tomography showed a mass lesion middle lobe atelectasis. The bronchoscopy polypoid lesions smooth surface in each bronchial lumen. histopathology revealed the dense accumulation of histiocyte-like cells foamy cytoplasm under epithelium along yeast-like fungi stained positively both Alcian blue Grocott's stains. Cryptococcus neoformans was cultured from washings. We diagnosed patient...
Patients with antisynthetase-positive interstitial lung disease (ILD) alone sometimes develop myositis during follow-up, but myasthenia gravis (MG) overlapping on antisynthetase syndrome is unusual. A 56-year-old woman ILD and anti-EJ antibody treated for 8 years developed MG. Physicians should consider MG when patients muscle symptoms follow-up.
Abstract Background Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies investigated smoking-associated lung diseases. Emphysema is major pathological finding smoking-related damage. We aimed to clarify effect emphysema sputum culture conversion rate for Mycobacterium (MTB). Methods retrospectively studied 79 male patients with PTB confirmed by acid-fast bacillus smear and at Jikei University Daisan Hospital between...
<title>Abstract</title> Background Visual abnormalities are relatively common side effects of voriconazole use, but optic neuropathy is rare and not well recognized. The aim this study was to investigate the characteristics patients diagnosed with during treatment. Methods We reviewed six who developed treatment at our hospital. acuity critical flicker fusion frequency (CFF) tests were used diagnose neuropathy. Results Voriconazole treat chronic pulmonary aspergillosis in all patients....
BackgroundThe incidence and etiologies of chronic pulmonary infection (CPI) in patients with idiopathic fibrosis (IPF) have been poorly investigated. Methods We conducted a retrospective study 659 IPF to assess the incidence, etiologies, risk factors CPI development. was defined if etiology diagnosed one or more months after onset symptoms upon appearance new shadows on radiological images. Results At diagnosis, 36 (5.5%) had CPI, 46 (7.0%) without at diagnosis developed over median...
Abstract Background Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies investigated smoking-associated lung diseases. Emphysema is major pathological finding smoking-related damage. We aimed to clarify effect emphysema sputum culture conversion rate for Mycobacterium (MTB). Methods retrospectively studied 79 male patients with PTB confirmed by acid-fast bacillus smear and at Jikei University Daisan Hospital between...
Abstract Background Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies investigated smoking-associated lung diseases. Emphysema is major pathological finding smoking-related damage. We aimed to clarify effect emphysema sputum culture conversion rate for Mycobacterium (MTB). Methods retrospectively studied 79 male patients with PTB confirmed by acid-fast bacillus smear and at Jikei University Daisan Hospital between...