A5057044706- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Brain Metastases and Treatment
- Pleural and Pulmonary Diseases
- Cancer Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Infectious Diseases and Mycology
- Pneumonia and Respiratory Infections
- Eosinophilic Disorders and Syndromes
- Occupational exposure and asthma
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA modifications and cancer
Kanagawa Cardiovascular and Respiratory Center
2016-2025
Boehringer Ingelheim (Canada)
2022
Weatherford College
2022
Patients First
2022
Hokkaido hospital
2019
Respiratory Clinical Trials
2017
National Hospital Organization
2012-2016
Ibarakihigashi National Hospital
2012-2016
University of Tsukuba
2008
Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue (MCTD). The heterogeneous, its outcome unpredictable. Some patients have severe progressive deterioration ILD, which the leading cause mortality. We aimed to determine whether serum levels Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity.We retrospectively analyzed medical records 40 ILD: 29 SSc 11 MCTD. Measurement KL-6...
There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of for such remains unclear. The objective this study was to identify factors that predicted survival benefit chemotherapy.All consecutive (≥75 years) NSCLC, Eastern Cooperative Oncology Group PS ≥2, EGFR mutation wild type/unknown, newly diagnosed from January 2009 December 2012 at a tertiary hospital were retrospectively reviewed.We...
Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrotic lung disease with poor prognosis. Some patients PPFE have prominent lesions in one upper lobe. Due to the unilateral nature of lesions, similarities between some and field pulmonary fibrosis (unilateral upper-PF) been indicated. A 55-year-old man was referred our hospital PPFE, which had developed dyspnea 9 months previously. He undergone resection renal cancer 64 prior onset PPFE. administered antifibrotic drug nintedanib, but...
Little has been reported on long-term pulmonary function trends among patients with interstitial lung disease associated anti-aminoacyl-tRNA synthetase antibodies (ARS-ILD).To clarify the factors predictive of progression in ARS-ILD based patients' initial clinical and radiological features.The courses 88 > 1 year follow-up data tests (PFTs) were retrospectively analyzed. Disease behavior was categorized into three groups: (1) improved or (2) worsened (defined as increases decreases,...
After the commercialization of nintedanib in Japan, a high incidence hepatotoxicity resulting treatment interruption was noted idiopathic pulmonary fibrosis (IPF) patients treated with our hospital. This study aimed to clarify risk factors for nintedanib. Sixty-eight consecutive cases IPF newly at dose 150 mg twice daily from September 2015 2016 were enrolled: 46 (67.6%) exhibited aspartate aminotransferase (AST) and/or alanine (ALT) elevation and 16 (23.5%) also had Common Terminology...
We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which became thicker and formed consolidation, resulting in remarkable loss volume. Specimens taken from SLB membranous organization alveolar occlusion, dilation ducts, sacs collapsed alveoli, are typical features diffuse damage (DAD)....
Abstract This prespecified subanalysis of the global, randomized controlled phase III KEYNOTE‐024 study pembrolizumab vs chemotherapy in previously untreated metastatic non ‐ small‐cell lung cancer without EGFR / ALK alterations and a programmed death ligand 1 (PD‐L1) tumor proportion score 50% or higher evaluated clinical outcomes among patients enrolled Japan. Treatment consisted 200 mg every 3 weeks (35 cycles) platinum‐based (four to six cycles). The primary end‐point was...
Non-small-cell lung cancer (NSCLC) with comorbid interstitial pneumonia (IP) is a population limited treatment options and poor prognosis. Patients IP are at high risk of developing fatal drug-induced pneumonitis, data on the safety efficacy molecularly targeted therapies lacking. KRAS mutations have been frequently detected in patients NSCLC IP. However, low detection rate common driver gene mutations, such as epidermal growth factor receptor anaplastic lymphoma kinase, results inadequate...
Aims To investigate the pathological features of idiopathic interstitial pneumonia ( IIP )‐associated pulmonary adenocarcinoma. Methods and results Surgically resected adenocarcinomas associated with (the group) without non‐ were subjected to analysis. Adenocarcinomas in group subdivided into two groups: one included tumours connected bronchiolar metaplasia honeycomb lesions H‐ group), other unrelated NH ‐ group). Histomorphological appearance immunohistochemical expression compared among...
Current clinical practice guidelines for idiopathic pulmonary fibrosis (IPF) conditionally recommend use of pirfenidone and nintedanib. However, an optimal treatment sequence has not been established, the data from to nintedanib are limited. This study aimed evaluate safety, tolerability efficacy switched in patients with IPF. Thirty consecutive IPF cases, which discontinued because a decline forced vital capacity (FVC) or intolerable adverse event (AE), newly started (150 mg twice daily)...
Cardiovascular magnetic resonance (CMR) provides non-invasive and more accurate assessment of right ventricular (RV) function in comparison to echocardiography. Recent study demonstrated that RV by echocardiography was an independent predictor for mortality patients with interstitial lung disease (ILD). The purpose this determine the prognostic significance CMR derived ejection fraction (RVEF) ILD patients. We enrolled 76 24 controls current study. By using 1.5 T scanner equipped 32 channel...
ABSTRACT Background and objective Non‐specific interstitial pneumonia (NSIP) has heterogeneous characteristics in terms of background, disease behaviour prognosis. This study fibrotic NSIP (f‐NSIP) aimed to elucidate prognosis from the viewpoint clinical background determine whether long‐term change pulmonary function could provide useful prognostic information. Methods We analysed medical records 157 consecutive patients diagnosed with f‐NSIP by surgical lung biopsy. Disease was categorized...
The JIPANG study is a randomized phase III of pemetrexed/cisplatin (Pem/Cis) versus vinorelbine/cisplatin (Vnr/Cis) for completely resected stage II-IIIA non-squamous non-small cell lung cancer (Ns-NSCLC). This did not meet the primary endpoint (recurrence-free survival, RFS) but Pem/Cis had similar efficacy to Vnr/Cis with better tolerability. Tumor mutation burden (TMB) thought have predictive value immune checkpoint inhibitors. However, relevance TMB cytotoxic chemotherapy remains...
Background: Pleuroparenchymal fibroelastosis (PPFE) is a unique clinical, radiologic, and histopathologic entity for which several potential etiologies have been reported recently. However, there has no comprehensive study of secondary PPFE. Objective: Assessment the clinical characteristics, outcomes, prognostic factors idiopathic Methods: We retrospectively reviewed medical records consecutive PPFE patients between January 1999 December 2018. identified 132 32 patients. Results: The...
Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD.This study was conducted to elucidate characteristics, prognosis, behavior in patients lung (ILD) associated systemic sclerosis (SSc)-related autoantibodies.We retrospectively analyzed medical records 72 ILD patients: 40 SSc (SSc-ILD) 32 SSc-related autoantibody-positive but CTD (ScAb-ILD), indicating...