A5003648443- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Quantum Chromodynamics and Particle Interactions
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- High-Energy Particle Collisions Research
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Nausea and vomiting management
- Colorectal and Anal Carcinomas
- T-cell and Retrovirus Studies
- Metastasis and carcinoma case studies
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
Yokohama City University
2014-2023
Chiba University
2023
Yokohama City University Hospital
2018-2021
National Cancer Center Hospital East
2011-2021
Osaka University
1999-2021
Kanagawa Prefectural Hospital Organization
2021
Kanagawa Cancer Center
2021
Yokohama City University Medical Center
2021
Tokyo Medical University
2010-2019
Inform (Germany)
2018
Abstract The number of deaths from colorectal cancer in Japan continues to increase. Colorectal exceeded 50,000 2016. In the 2019 edition, revision all aspects treatments was performed, with corrections and additions made based on knowledge acquired since 2016 version (drug therapy) 2014 (other treatments). Japanese Society for Cancer Colon Rectum guidelines treatment (JSCCR 2019) have been prepared show standard strategies cancer, eliminate disparities among institutions terms treatment,...
Since 2004, a regimen of 6 months treatment with oxaliplatin plus fluoropyrimidine has been standard adjuvant therapy in patients stage III colon cancer. However, since is associated cumulative neurotoxicity, shorter duration could spare toxic effects and health expenditures.
Noninvasive methods have been evaluated for the assessment of liver fibrosis and steatosis in patients with nonalcoholic fatty disease (NAFLD). We compared ability transient elastography (TE) M-probe, magnetic resonance (MRE) to assess fibrosis. Findings from imaging (MRI)-based proton density fat fraction (PDFF) measurements were those TE-based controlled attenuation parameter (CAP) steatosis.We performed a cross-sectional study 142 NAFLD (identified by biopsy; mean body mass index, 28.1...
Abstract Background Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), aimed to identify factors. Methods Data were collected retrospectively all consecutive who underwent HCC curative intent between January 2004 December 2009. Patients assigned one two groups according presence or absence sarcopenia,...
In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine prognostic implications N/L ratio in peripheral blood gastric patients.Study participants were identified from a prospective cohort patients advanced Japan (n = 1,220).The median baseline 2.58 (range, 0.63-12.7). Univariate analysis revealed that an > pr =2.5 644) had significantly poorer prognosis than those <2.5 576; log rank...
In Brief Objective: To clarify the prognostic value of preoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Background: Although a high NLR has been reported to be predictor poor survival with various cancers, it not extensively examined HCC. Methods: This retrospective study enrolled 958 who underwent without therapy HCC from 1996 2009. Clinicopathological parameters, including NLR, were evaluated identify predictors...
Purpose Approximately 1% to 2% of non-small-cell lung cancers (NSCLCs) harbor a c-ros oncogene 1 ( ROS1) rearrangement. Crizotinib, an inhibitor anaplastic lymphoma kinase (ALK), ROS1, and MET, has shown marked antitumor activity in small expansion cohort patients with ROS1-positive advanced NSCLC from ongoing phase I study. We assessed the efficacy safety crizotinib largest NSCLC. Patients Methods This II, open-label, single-arm trial enrolled East Asian (assessed through validated AmoyDx...
A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With data collected in 2015, corresponding to 2.2×10^{19} protons on target, a single event sensitivity of (1.30±0.01_{stat}±0.14_{syst})×10^{-9} achieved and no candidate events were observed. We set an upper limit 3.0×10^{-9} branching fraction at 90% confidence level (C.L.), which improved previous by almost order magnitude. An K_{L}→π^{0}X^{0} also as 2.4×10^{-9} C.L., where X^{0} is invisible boson with mass 135 MeV/c^{2}.
This study evaluated the continuous use of trastuzumab beyond progression (TBP) in human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction (G/GEJ) cancer.Patients with HER2-positive G/GEJ cancer refractory to first-line chemotherapy combination fluoropyrimidine and platinum were eligible. Patients randomly assigned paclitaxel (80 mg/m2, days 1, 8, 15, every 4 weeks) (PT; initially 8 mg/kg followed by 6 mg/kg, 3 arms. The primary endpoint was...
Abstract Adjuvant chemotherapy has reduced the risk of tumor recurrence and improved survival in patients with resected colorectal cancer. Potential utility circulating DNA (ctDNA) prior to post surgery been reported across various solid tumors. We initiated a new type adaptive platform trials evaluate clinical benefits ctDNA analysis refine precision adjuvant therapy for resectable cancer, named CIRCULATE‐Japan including three trials. The GALAXY study is prospectively conducted large‐scale...
Abstract A number of preclinical studies have indicated the therapeutic potential endothelial progenitor cells for vascular regeneration in ischemic diseases. phase I/IIa clinical trial transplantation autologous CD34+ cells, and hematopoietic progenitor-enriched fraction, was performed no-option patients with atherosclerotic peripheral artery disease or Buerger's critical limb ischemia (CLI). were isolated from G-CSF-mobilized apheresis product using a magnetic cell sorting system. (105/kg,...
Purpose The prognosis of acute- and lymphoma-type adult T-cell leukemia/lymphoma (ATL) is poor, but there marked diversity in survival outcomes. aim this study was to develop a prognostic index (PI) for ATL (ATL-PI). Patients Methods In retrospective review, data from 807 patients newly diagnosed with between January 2000 May 2009 were evaluated. We randomly divided subjects into training (n = 404) validation 403) samples, developed PI using multivariable fractional polynomial model. Results...
Abstract Although previous studies have indicated important roles of palmitate, a saturated fatty acid, in the pathogenesis nonalcoholic liver disease (NAFLD), it remains unclear how palmitate contributes to inflammation and fibrosis liver. Administration high fat diet (HFD)-fed but not basal (BD)-fed mice resulted an increase serum alanine aminotransferase (ALT) levels. Surprisingly, combined administration very low dose lipopolysaccharide palmitate-treated led marked ALT levels despite...