A5021379709- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Nausea and vomiting management
- Anesthesia and Pain Management
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Pathogenesis and Treatment of Hiccups
- HER2/EGFR in Cancer Research
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- Renal cell carcinoma treatment
- Chronic Lymphocytic Leukemia Research
- Drug Transport and Resistance Mechanisms
- Economic and Financial Impacts of Cancer
- Cancer Cells and Metastasis
- Chronic Myeloid Leukemia Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Cancer therapeutics and mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Pharmacy and Medical Practices
Showa University
2019-2025
Translational Research Institute
2021-2024
Keio University
2013-2022
Weatherford College
2021
Kubota (Japan)
2021
Pharmac
2013-2019
University of Florida
2016
Princeton University
2016
Nagoya University Hospital
2015
The University of Tokyo
2010
Purpose The clinical efficacy of tamoxifen is suspected to be influenced by the activity drug-metabolizing enzymes and transporters involved in formation, metabolism, elimination its active forms. We investigated relationships polymorphisms transporter genes CYP2D6 outcome patients receiving tamoxifen. Patients Methods studied 282 with hormone receptor–positive, invasive breast cancer monotherapy, including 67 who have been previously reported. effects allelic variants haplotype-tagging...
Abstract Patients with cancer should appropriately receive antiemetic therapies against chemotherapy-induced nausea and vomiting (CINV). Antiemetic guidelines play an important role in managing CINV. Accordingly, the first Japanese guideline published 2010 by Japan Society of Clinical Oncology (JSCO) has considerably aided medical staff providing across chemotherapy clinics. With yearly advancements therapies, require revisions according to evidence regarding management worldwide. A revised...
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) synergistically increased the effectiveness of antiprogrammed cell death protein-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibodies in preclinical studies. Methods This non-randomized, multicohort, phase II study evaluated efficacy safety anti-PD-1 antibody nivolumab 240 mg administered every...
Abstract Background The Japan Society of Clinical Oncology Practice Guidelines for Antiemesis 2023 was extensively revised to reflect the latest advances in antineoplastic agents, antiemetics, and regimens. This update provides new evidence on efficacy antiemetic Methods Guided by Minds Guideline Development Manual 2017, a rigorous approach used guidelines; thorough literature search conducted from January 1, 1990, December 31, 2020. Results Comprehensive process resulted creation 13...
Spliced variant isoforms of CD 44 ( 44v) are a marker cancer stem cells in solid tumors. They stabilize the xCT subunit transporter system xc(–) and thereby promote synthesis antioxidant glutathione. Salazosulfapyridine SASP ) is an inhibitor suppresses proliferation 44v‐positive cells. Chemotherapy‐naïve patients with advanced non‐squamous non‐small‐cell lung were enrolled dose‐escalation study (standard 3 + design) combination cisplatin pemetrexed. The primary end‐point was percentage who...
Although many association studies of polymorphisms in candidate genes with the clinical outcomes breast cancer patients receiving adjuvant tamoxifen therapy have been reported, genetic factors determining individual response to are not fully understood. To identify associated treatment, we conducted a genome-wide study (GWAS). We studied 462 Japanese hormone receptor-positive, invasive therapy. Of them, 240 were analyzed by genotyping using Illumina Human610-Quad BeadChips, and two...
This study evaluated the effects of cytochrome P450 (CYP) 2C19 polymorphisms on tacrolimus pharmacokinetics when coadministered with voriconazole. Eighteen healthy volunteers, including 6 individuals in each CYP2C19 genotype (extensive metabolizers [EMs], intermediate [IMs], and poor [PMs]), received a single oral dose 3 mg alone or combination 200 voriconazole twice daily at steady state. When was voriconazole, significant increase area under its concentration-time curve (AUC0-24 ) observed...
We developed and refined an S-1 dosage formula based on renal function, sex, body surface area (BSA) to achieve the target under concentration-time curve of 5-fluorouracil in two prospective pharmacokinetic studies. The clinical validity (BBT formula) was evaluated using data from phase III trials fist-line chemotherapy including for advanced gastric cancer, which demonstrated that overall survival progression-free tended be shorter patients whose standard dose, BSA alone, lower than...
Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that acts against receptors for vascular endothelial growth factor and platelet-derived factor. Common toxicities of sunitinib treatment include hypertension, hand–foot syndrome, vomiting, diarrhea, the proportion grade 3 or 4 adverse events relating to range from 1 13% all categories. It reported increased exposure associated with improved clinical outcomes but also carries an risk effects. A 73-year-old Japanese woman...
In patients taking tamoxifen, the CYP2D6 genotype causes different exposure of active metabolite endoxifen. The objective this randomized, open-label, multicenter, phase II study was to prospectively evaluate whether genotype-guided tamoxifen dosing in with hormone receptor-positive metastatic breast cancer could have an impact on clinical outcome.Patients who needed first-line therapy were enrolled. Based individual genotype, heterozygous (wild type [wt]/variant [V]) or homozygous (V/V) for...
Abstract Introduction: Immune checkpoint inhibitors (ICIs), particularly anti-PD-1 antibody, have dramatically changed cancer treatment; however, fatal immune-related adverse events (irAEs) can develop. Here, we describe a severe case of sclerosing cholangitis-like irAE. We report the use 3 immunosuppressive agents that resulted in death patient due to treatment inefficacy. According postmarketing study nivolumab, frequency ICI-related cholangitis is 0.27% and 0.20%. There been 4 reports...
Abstract Purpose To investigate whether palonosetron is better than granisetron in preventing chemotherapy‐induced nausea and vomiting (CINV) a three‐drug combination with dexamethasone fosaprepitant (Fos) patients breast cancer who are placed on anthracycline cyclophosphamide (AC‐based regimen). Patients Methods Chemo‐naive women primary were randomly administered either 0.75 mg (day 1) or 1 combined (12 at day 1, 8 2 3) Fos 150 before receiving AC‐based regimen double‐blind study. The...
The hybrid liposomes (90mol% DMPC/10mol% C12 (EO)8 and 90mol% (EO)12) have a highly inhibitory action against the growth of tumor cells. uniform stable structure was revealed on basis electron microscopy dynamic light scattering measurements.