A5035682381- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Animal Nutrition and Physiology
- Sarcoidosis and Beryllium Toxicity Research
- Ruminant Nutrition and Digestive Physiology
- Animal Behavior and Welfare Studies
- Meat and Animal Product Quality
- Rabbits: Nutrition, Reproduction, Health
- Cardiac Imaging and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological disorders and treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Philosophy, Science, and History
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Phytase and its Applications
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
Harvard University
2019-2025
Brigham and Women's Hospital
2019-2025
Hospital Universitario de San Vicente Fundación
2024
University of Graz
1983-2021
Aurora University
2018-2021
Baylor Jack and Jane Hamilton Heart and Vascular Hospital
2021
University of Colorado Denver
2011-2020
University of Colorado Anschutz Medical Campus
2011-2020
Vanderbilt Health
2020
University of Colorado Hospital
2007-2020
Background— Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited genetic myocardial disease characterized by fibrofatty replacement of the myocardium and a predisposition to cardiac arrhythmias sudden death. We evaluated gene titin ( TTN ) as candidate ARVC because its proximity locus at position 2q32 connection protein transitional junction intercalated disks. Methods Results— All 312 exons known be expressed in human complete 3′ untranslated region were sequenced 38...
Structured Abstract Background and Aims Studies have shown correlations between early recurrence (ER) late (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyze ER versus LR in patients paroxysmal fibrillation (PAF) undergoing pulsed field (PFA). Methods Patients symptomatic ≥1 transtelephonic monitoring transmission during the blanking period were included (n=169). was defined as documented (days 1–90), evaluation...
Background Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this through attenuation of serotonin-mediated platelet activation in addition to treatment depression itself. Methods and Results A case-control study first MI smokers 30 65 years age was conducted among all 68 hospitals 8-county area during a 28-month period. Cases were patients hospitalized with MI. Approximately 4 community control subjects per...
Evaluation of ventricular rate control in atrial fibrillation (AF) can be difficult, and the presence an AF-induced cardiomyopathy due to intermittent poor or other causes may underestimated. The outcome with AF ablation patients a decreased left ejection fraction (LVEF) provide insight into this important clinical issue.To determine effect pulmonary vein isolation on LVEF (< = 50%).Ablation consisted proximal arrhythmogenic veins (PVs) elimination non-PV triggers. was determined within 24...
Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), attenuate platelet activation by depleting storage and may decrease risk of myocardial infarction (MI). These drugs differ in their affinity for the transporter therefore vary effects on MI protection.A case-control study first patients aged 40 through 75 years was conducted among 36 hospitals a 5-county area during 3-year period. Case subjects were hospitalized with MI, control randomly selected from same...
Nine barrows with an average initial weight of 60 kg were fitted simple T-cannulas at the distal ileum. The animals fed four different protein-free diets according to incomplete latin square design. Diet 1 (control diet) consisted 79.7% cornstarch, 10% sucrose, 3% Alphafloc (a source cellulose), canola oil and a vitamin-mineral premix. Diets 2, 3 4 contained, respectively, 4% pectin, additional 7% cellulose oil, each included expense cornstarch. Feces collected during d following 7-d...
A method for measuring protein digestibility of small feed samples was developed with growing pigs fitted a single cannula in the duodenum. Feed ground through 0.8-mm mesh screen and 1-g were enclosed 25 × 40-mm monofilament nylon bags (50-μm mesh). Following pre-digestion vitro to simulate gastric digestion (0.01 N HCI; pepsin 1 g/L; 2.5 h), inserted into intestine via duodenal cannula, recovered feces within 48 h, frozen, lyophilized analyzed protein. Apparent soybean meal meat-and-bone...
Studies were carried out to investigate the effect of dietary amino acid level on apparent ileal digestibility. Six barrows, average initial BW 35 kg, fitted with a simple T-cannula at distal ileum and fed six diets according 6 × Latin square design. cornstarch-based containing levels CP from SBM (4, 8, 12, 16, 20, 24% CP, respectively) formulated. Chromic oxide was included as digestibility marker. Each experimental period consisted 8 d. After 6-d adaptation period, digesta collected for 24...
Radiofrequency ablation of multiple or unmappable ventricular tachycardias (VTs) remains a challenge with unclear end points. We present our experience new strategy isolating core elements VT circuits.Patients structural heart disease presenting for radiofrequency at 2 centers were included. Strategy involved entrainment/activation mapping if was hemodynamically stable, and voltage electrogram analysis pacemapping. Core isolation (CI) performed incorporating putative isthmus early exit...
Implantable cardiac defibrillator (ICD) implantation is a class IIA recommendation for patients with sarcoidosis (CS). However, little known about the efficacy and safety of ICDs in this population. The goal multicentre retrospective data review was to evaluate CS.Electrophysiologists at academic medical centres were asked identify consecutive CS an ICD. Clinical information, ICD therapy history, device complications collected each patient. Data on 235 from 13 institutions, 64.7% male mean...
In patients referred for radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in the setting structural heart disease, early post-procedural mortality (EM) has not been previously investigated. The purpose this study was to evaluate EM after scar-related VT. Associations between clinical and procedural variables (within 31 days procedure) were tested with disease undergoing RFCA VT at 12 international centers. Of 2,061 (mean age 62 ± 13 years; left ejection fraction [LVEF]...
Diarrhea incidence in weaned pigs may be associated with the concentration of intestinal microbial metabolites (ammonia, amines, and VFA) that are influenced by dietary CP content. Three experiments were conducted to determine effects a low-protein, AA-supplemented diet on ileal AA digestibility, growth performance, diarrhea incidence, cecal digesta at 14 d age. In Exp. 1, 8 fitted simple T-cannula distal ileum assigned crossover design 2 diets containing 24 or 20% using wheat, corn,...
ICD Shocks in Cardiac Sarcoidosis.An implantable cardioverter defibrillator (ICD) is indicated for some patients with cardiac sarcoidosis (CS) prevention of sudden death. However, there are little data regarding the event rates therapies these patients. We sought to identify incidence and characteristics this patient population.We performed a cohort study ICDs at 3 institutions. Cases were those CS an implanted primary or secondary Additionally, we included comparison historical controls...
The purpose of this study was to assess whether delayed enhancement (DE) on MRI is associated with ventricular tachycardia (VT)/ventricular fibrillation or death in patients cardiac sarcoidosis and left ejection fraction >35%. Fifty-one >35% underwent DE-MRI. DE assessed by visual scoring quantified the full-width at half-maximum method. were followed for 48.0 ± 20.2 months. Twenty-two 51 (63%) had DE. Forty no prior history VT (primary prevention cohort). Among those, 3 developed 2 died....