Vivek Iyer
A5103072904- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Semantic Web and Ontologies
- Natural Language Processing Techniques
- ECG Monitoring and Analysis
- Neuroscience and Neural Engineering
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Data Quality and Management
- Topic Modeling
- Diabetes and associated disorders
- Hospital Admissions and Outcomes
- Mechanical Circulatory Support Devices
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Network Security and Intrusion Detection
- Security and Verification in Computing
- Genomics and Rare Diseases
- Cardiovascular Function and Risk Factors
- Health, Environment, Cognitive Aging
- COVID-19 Clinical Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
Wellcome Sanger Institute
2023-2025
Marin Endocrine Care and Research
2019-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Indian Institute of Technology Hyderabad
2022
Columbia University
2010-2021
University of Edinburgh
2021
International Institute of Information Technology, Hyderabad
2020
Columbia University Irving Medical Center
2011-2019
Mayo Clinic in Arizona
2017
Wayne State University
2017
Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added standard care for COVID-19 pneumonia. Design, Setting, and Participants Randomized, double-masked, placebo-controlled clinical trial using a master protocol immunomodulators treatment of participants hospitalized with The results 3 substudies are reported from 95 hospitals at 85 research sites the US Latin America....
Structured Abstract Background and Aims Studies have shown correlations between early recurrence (ER) late (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyze ER versus LR in patients paroxysmal fibrillation (PAF) undergoing pulsed field (PFA). Methods Patients symptomatic ≥1 transtelephonic monitoring transmission during the blanking period were included (n=169). was defined as documented (days 1–90), evaluation...
The delayed rectifier I Ks potassium channel, formed by coassembly of α- (KCNQ1) and β- (KCNE1) subunits, is essential for cardiac function. Although KCNE1 necessary to reproduce the functional properties native mechanism(s) through which modulates KCNQ1 unknown. Here we report measurements voltage sensor movements in KCNQ1/KCNE1 channels using clamp fluorometry. exhibit indistinguishable dependence fluorescence current signals, suggesting a one-to-one relationship between movement channel...
BACKGROUND: Evidence from clinical trials of early pulsed field ablation (PFA) systems in treating atrial fibrillation has demonstrated their promising potential to reduce complications associated with conventional thermal modalities while maintaining efficacy. However, the lack a fully integrated mapping system, staple technology most modern electrophysiology procedures, poses limitations lesion creation and workflow options. A novel variable-loop PFA catheter an electroanatomic system been...
A chromosomal haplotype producing cardiac overexpression of dipeptidyl peptidase-like protein-6 (DPP6) causes familial idiopathic ventricular fibrillation. The molecular basis transient outward current (I(to)) in Purkinje fibers (PFs) is poorly understood. We hypothesized that DPP6 contributes to PF I(to) and its might specifically alter properties repolarization.To assess the potential role I(to).Clinical data 5 fibrillation patients suggested arrhythmia origin PF-conducting system. muscle...
QT interval-prolonging drug-drug interactions (QT-DDIs) may increase the risk of life-threatening arrhythmia. Despite guidelines for testing from regulatory agencies, these are usually discovered after drugs marketed and go undiscovered years. Using a combination adverse event reports, electronic health records (EHR), laboratory experiments, goal this study was to develop data-driven pipeline discovering QT-DDIs. 1.8 million reports were mined signals indicating QT-DDI. 1.6 electrocardiogram...
Ventricular arrhythmias (VAs) are common after implantation of a left ventricular assist device (LVAD) and in subset patients may be refractory to medication. Morbidity from VA this population includes right failure (RVF). We sought evaluate the efficacy catheter ablation for with LVAD. A retrospective analysis supported by continuous-flow LVAD referred tachycardia (VT) between 2008 present was performed. Seven were VT an average 236 ± 292 days implantation. Three (42.9%) developed RVF...
Abstract South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores (pPSs) to elucidate underlying etiological pathways British Pakistani Bangladeshi individuals T2D ( n = 11,678) gestational mellitus (GDM) 1,965) the Genes & Health study 50,556). Beta cell...
Correct classification of type 1 (T1D) and 2 diabetes (T2D) is challenging due to overlapping clinical features the increasingly early onset T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D T2D have been shown work relatively well Asians, despite being derived from largely European-ancestry samples. Here we used PRSs investigate rate potential misclassification amongst British Bangladeshis Pakistanis. Using linked health records Genes & Health cohort (n = 38,344)...
Human embryonic stem cells (hESCs) are an important cellular model for studying ion channel function in the context of a human cardiac cell and will provide wealth information about both heritable arrhythmias acquired electrophysiological disorders. However, detailed characterization channels has been so far overlooked. Because mutations gene I(Ks) α subunit, KCNQ1, constitute majority long QT syndrome (LQT-1) cases, we have carried out biophysical analysis this expressed hESCs to establish...
Significance Na v 1.1 is a potential therapeutic target for brain disorders, such as epilepsy, Alzheimer's disease, and autism. Moreover, this voltage-gated sodium (Na ) channel subtype contributes to mechanical pain by regulating excitability in specific subset of sensory neurons within the peripheral nervous system. The results our study shed light on molecular mechanisms underlying inactivation suggest pharmacologic approaches address relevant disease-related phenotypes.
Abstract Long QT syndrome (LQTS) is characterized by ventricular arrhythmias and sudden cardiac death. Purkinje cells (PC) within the specialized conduction system have unique electrophysiological properties that we hypothesize may produce primary sources of arrhythmia in heritable LQTS. LQTS type 3 (LQT3) transgenic mice harboring ΔKPQ +/− mutation were crossed with Contactin2-EGFP BAC mice, which express a fluorescent reporter gene fiber network. Isolated myocytes (VMs) (EGFP − ) PCs +...
Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity mortality. Recently, we created a mouse model with spontaneous sustained AF caused by mutation in NaV1.5 channel (F1759A) that enhances persistent Na+ current, thereby enabling investigation of molecular mechanisms cause identification potentially novel treatment strategies. The mice have regional heterogeneity action potential duration atria similar to observations patients AF. In these...
Leadless pacemakers (LPMs) have been shown to lower postoperative complications than traditional permanent but there no studies on the outcomes of LPMs in patients with transcatheter heart valve replacements (THVRs). This study determined compared transvenous single-chamber (SCPs) post-THVR.This is a retrospective single-center including 10 who received post-THVR between February 2017 and August 2018 comparison group 23 SCP July 2008 2018. LPM or was implanted at discretion...
Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects human physiology. We report a genome-wide association study 42 quantitative test traits defined using Electronic Healthcare Records (EHRs) ~50,000 British Bangladeshi and Pakistani adults. demonstrate causal variant within PIEZO1 locus which was associated with alterations in red cell glycated haemoglobin. Conditional analysis within-ancestry fine mapping confirmed that this signal is...
Catecholaminergic polymorphic ventricular tachycardia is a heritable arrhythmia unmasked by exertion or stress and characterized triggered activity sudden cardiac death. In this study, we simulated mutations in 2 genes linked to catecholaminergic tachycardia, the first located calsequestrin (CSQN2) second ryanodine receptor (RyR2). The aim of study was investigate mechanistic basis for spontaneous Ca2+ release events that lead delayed afterdepolarizations affected patients. Sarcoplasmic...
Despite considerable advances in guidance of radiofrequency ablation (RFA) therapy for the treatment cardiac arrhythmias, success rates have been hampered by a lack tools precise intraoperative evaluation lesion extent. Near-infrared spectroscopic (NIRS) techniques are sensitive to tissue structural and biomolecular properties, characteristics that directly altered (RF) treatment. In this work, combined NIRS-RFA catheter is developed real-time monitoring reflectance during RF energy...
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. The 12-lead electrocardiogram (ECG) is the current noninvasive clinical tool used to diagnose localize cardiac arrhythmias. However, it has limited accuracy subject operator bias. Here, we present electromechanical wave imaging (EWI), high-frame rate ultrasound technique that can noninvasively map with high activation atrial ventricular in adult patients. This study evaluates EWI for localization various all four...
The pharmacokinetics of abatacept and the association between exposure outcomes in patients with severe COVID-19 are unknown.