A5082139259- Retinal Diseases and Treatments
- Cystic Fibrosis Research Advances
- COVID-19 Clinical Research Studies
- Smoking Behavior and Cessation
- COVID-19 and healthcare impacts
- Retinoids in leukemia and cellular processes
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Retinal Development and Disorders
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Long-Term Effects of COVID-19
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Chemokine receptors and signaling
- Tracheal and airway disorders
- Extracellular vesicles in disease
- Ocular Diseases and Behçet’s Syndrome
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Renal function and acid-base balance
- Respiratory viral infections research
Tulane University
2019-2025
University of California, San Diego
2018-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Pulmonary and Critical Care Associates
2024
Inform (Germany)
2024
University of Maryland, College Park
2024
VA San Diego Healthcare System
2019-2021
Johns Hopkins University
2021
University of California System
2018-2020
Southeast Louisiana Veterans Health Care System
2019-2020
Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added standard care for COVID-19 pneumonia. Design, Setting, and Participants Randomized, double-masked, placebo-controlled clinical trial using a master protocol immunomodulators treatment of participants hospitalized with The results 3 substudies are reported from 95 hospitals at 85 research sites the US Latin America....
This study examined the association between sequence variation/expression of CX3CR1, a chemokine receptor, and age-related macular degeneration (AMD). Peripheral blood from 85 AMD patients 105 subjects without (controls), as well ocular tissue 40 pathological sections with two normal eye sections, were screened for V249I T280M, single nucleotide polymorphisms (SNPs) in CX3CR1. An increased prevalence, highest odds ratio 3.57, I249 M280 carriers was found among cases compared controls. When...
Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 also found be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) establish a more characteristic and reproducible AMD model.Single Ccl2- Cx3cr1-deficient were crossbred obtain mice. Funduscopy, histopathology, retinal A2E quantification, proteomics, RT-PCR gene expression assay, immunochemistry,...
Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity, and diabetes. We examined the association between diabetes, individually clustered as metabolic syndrome (MetS), COVID-19 outcomes hospitalized New Orleans during peak of outbreak.
E-cigarettes are portrayed as safer relative to conventional tobacco. However, burgeoning evidence suggests that may adversely affect host defenses. the precise mechanisms by which E-cigarette vapor alters innate immune cell function have not been fully elucidated. We determined effects of exposure on and responses infectious challenge most abundant cell, neutrophil, using isolated human neutrophils a mouse model gram-negative infection. Our results revealed exposed had 4.2-fold reductions...
Abstract Sensitive and specific blood-based assays for the detection of pulmonary extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses, particularly in children. Here we report a nanoparticle-enhanced immunoassay read by dark-field microscopy that detects two Mycobacterium virulence factors (the glycolipid lipoarabinomannan its carrier protein) on surface circulating extracellular vesicles. In cohort study 147 hospitalized severely immunosuppressed children...
This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP) and its disease association. We chose ERCC6 because roles in the aging process, DNA repair, ocular from gene disruption. Bioinformatics indicated putative binding-element alteration on sequence containing C-6530>G SNP 5' flanking region Sp1 C allele to SP1, GATA-1, OCT-1 G allele. Electrophoretic mobility shift assays displayed...
<i>Background/Aims:</i> Senescent <i>Ccl2</i><sup>–/–</sup> mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within <i>CX3CR1</i> are associated with AMD. <i>Methods:</i> We generated <i>Ccl2</i><sup>–/–</sup><i>/Cx3cr1</i><sup>–/–</sup> [double-knockout (DKO)] and evaluated the eyes using fundoscopy...
Conventional smoking is known to both increase susceptibility infection and drive inflammation within the lungs. Recently, smokers have been found be at higher risk of developing severe forms coronavirus disease 2019 (COVID-19). E-cigarette aerosol inhalation (vaping) has associated with several inflammatory lung disorders, including recent e-cigarette or vaping product use-associated injury (EVALI) epidemic, studies suggested that alters host pathogens such as acute respiratory syndrome 2...
There is a significant genetic component in age-related macular degeneration (AMD). CX3CR1, which encodes the fractalkine (chemokine, CX3CL1) receptor, has two single nucleotide polymorphisms (SNPs): V249I and T280M. These SNPs are correlated with other aged-related diseases such as atherosclerosis. We have reported an association of CX3CR1 SNP AMD. In this study we examined frequencies protein expression on archived sections AMD normal eyes. microdissected non-retinal, peripheral retinal...
purpose. Age-related macular degeneration (AMD) is a multifactorial blinding disease in the elderly. LOC387715 harbors single-nucleotide polymorphism that has an association with AMD. This study was conducted to confirm between and AMD refine estimates of impact this gene variation using samples from three studies: Australian population-based two U.S. clinic-based case–control studies. methods. Cases controls were collected National Eye Institute (NEI) clinical protocol (n = 240),...
Electronic (E)-cigarettes are the latest form of nicotine delivery device, and highly popular in general population. It is currently unknown whether vaping E-cigarettes (E-CIGs) leads to addiction. Alterations levels neurotransmitters mesocorticolimbic areas have been reported mediate initiation development Therefore, determine activate same addiction pathways as conventional cigarettes, we investigated for effects daily inhalation (24 mg/mL) containing E-CIG vapor six-months on...
The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” each E-liquid—which flavorings (flavoring chemicals) are present and at what concentrations not just focusing on flavor label. We investigated flavoring profile 10 different E-liquids. assessed bronchial epithelial cell viability apoptosis, phagocytosis bacteria apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). validated our data normal human (NHBE)...
Electronic (e)-cigarettes have been advocated as a safer alternative to conventional tobacco cigarettes. However, there is paucity of data regarding the impact e-cigarette aerosol deposition on human oral microbiome, key component in health and disease. We aimed fill this knowledge gap through comparative analysis microbial community profiles from users healthy controls [non-smokers/non-vapers (NSNV)]. Moreover, we sought determine whether exposure vaping induces persistent changes...
Bacteria of clinical importance, such as Pseudomonas aeruginosa, can become hypermutators upon loss DNA mismatch repair (MMR) and are clinically correlated with high rates multidrug resistance (MDR). Here, we demonstrate that hypermutated MMR-deficient P. aeruginosa has a unique mutational signature rapidly acquires MDR repeated exposure to first-line or last-resort antibiotics. acquisition was irrespective drug class instead arose through common mechanisms shared between the initial...
Coronavirus disease 2019 (COVID-19) has disproportionately impacted the African American community. This study aims to identify risk factors for severe COVID-19 in patients.This was a retrospective cross-sectional analysis of patients with treated between March 12 and April 9, 2020, at single tertiary center. The primary outcome interest defined as those requiring intensive care unit (ICU) admission.The included 158 consecutive patients. mean age 57 years, 61% were women. (SD) BMI 33.2 (8.6)...
To compare time to clinical worsening (TTCW) based on initial oral therapy for pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc)-related PAH.Using data from the Pulmonary Hypertension Assessment and Recognition of Outcomes Scleroderma (PHAROS) registry (a multicenter prospective observational study enrolling SSc incident hypertension), we selected group 1 PAH (World Health Organization Clinical Classification system) who received (for 6 months) an endothelin...