A5100335457- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Magnetic Properties of Alloys
- Advanced Sensor and Energy Harvesting Materials
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- RNA Research and Splicing
- 3D Printing in Biomedical Research
- Supercapacitor Materials and Fabrication
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Magnetic properties of thin films
- Conducting polymers and applications
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Advancements in Battery Materials
- Electrospun Nanofibers in Biomedical Applications
- Magnetic Properties and Applications
- biodegradable polymer synthesis and properties
- Neuroscience and Neural Engineering
- Magnetic and transport properties of perovskites and related materials
- Perovskite Materials and Applications
- MXene and MAX Phase Materials
Beijing Institute of Nanoenergy and Nanosystems
2015-2025
Chinese Academy of Sciences
2012-2025
Shanxi Medical University
2025
Yangzhou University
2024-2025
PowerChina (China)
2025
Nanjing Medical University
2010-2025
University of Chinese Academy of Sciences
2015-2024
National Center for Nanoscience and Technology
2015-2024
Hebei University of Technology
2019-2024
Mianyang Central Hospital
2024
Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer cells with minimal invasiveness specificity. In this study, we demonstrate self-assembled copper-amino acid mercaptide nanoparticles (Cu-Cys NPs) in situ glutathione-activated H2O2-reinforced chemodynamic therapy drug-resistant breast cancer. After endocytosis into cells, Cu-Cys NPs could first react local GSH,...
Engineered conductive scaffolds toward neural regeneration should have the ability to regulate mesenchymal stems cell (MSC) differentiation into lineage through an electrical stimulation-assisted culture process. In this work, a self-powered system for MSCs was realized by combining high effective triboelectric nanogenerator (TENG) supply pulsed electric simulation signals and poly(3,4-ethylenedioxythiophene) (PEDOT)–reduced graphene oxide (rGO) hybrid microfiber (80 μm in diameter) as...
Nondestructive, high-efficiency, and on-demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, biomechanical-energy-powered triboelectric nanogenerator (TENG)-driven electroporation system is developed drug with high efficiency minimal cell damage in vitro vivo. In the integrated system, self-powered TENG as stable voltage pulse source triggers increase of plasma membrane potential permeability. Cooperatively, silicon nanoneedle-array...
Pathogenic bacterial infections pose a significant threat to human life, health, and socioeconomic development, with those arising from Escherichia coli (E. coli) O157:H7 being particularly concerning. Herein, customized aggregation-induced emission luminogens (AIEgen)-based signaling tags (TPA-galactose) were combined microfluidic chip for the determination of E. O157:H7. TPA-galactose undergoes hydrolysis by β-galactosidase, resulting in formation highly fluorescent TPA–OH AIE...
To meet the growing demands in flexible and wearable electronics, various sensors have been designed for detecting monitoring physical quantity changes. However, most of these can only detect one certain kind based on a single mechanism. In this paper, we fabricated multifunctional sensor made from carbonized electrospun polyacrylonitrile/barium titanate (PAN-C/BTO) nanofiber film. It two quantities (pressure curvature), independently simultaneously, by integrating piezoresistive,...
Multicolor conjugated polymer nanoparticles (CPNs) are designed and biofunctionalized with antibody for targeted cell imaging detection. In comparison to single-antibody recognition mode tumor cells, enhanced specificity detection of cells is achieved by binding two functionalized CPNs one cell. This strategy provides a new platform designing useful imaging, other biological applications. Conjugated nanoparticles combine the properties polymers (CPs) define class promising fluorescence...
The PADM–rGO hybrid scaffold is a promising candidate for nerve regeneration, which can not only support the adhesion and proliferation of MSCs but also enhance cells neural differentiation.
Multidrug resistance (MDR) is the key cause that accounts for failure of clinical cancer chemotherapy. To address problem, herein, we presented an alternative strategy to conquer drug-resistant breast through combinatorial delivery Ca2+ channel siRNA with cytotoxic drugs. Mesoporous silica nanocapsules (MSNCs) mesoporous and hollow structure were fabricated co-delivery T-type doxorubicin (DOX) high drug loading efficiency. The DOX/siRNA co-loaded MSNCs showed a synergistic therapeutic effect...
The influence of graphene quantum dots (GQDs) on key characteristics bone marrow derived mesenchymal stem cells (MSCs) phenotype (i.e., self‐renewal, differentiation potential, and pluripotency) is systematically investigated in this work. First, the viability impact GQDs self‐renewal potential MSCs evaluated order to determine a threshold for exposing dose. Second, uptake by confirmed due excellent fluorescent properties particles. They exhibit homogenous cytoplasmatic distribution that...
Abstract The biophysical characteristics of the extracellular matrix, such as nanotopography and bioelectricity, have a profound influence on cell proliferation, adhesion, differentiation, etc. Recognition function certain cue fabrication biomaterial scaffolds with specific properties would important implications significant applications in tissue engineering. Herein, nanotopographic piezoelectric biomaterials are fabricated combination effect individual contribution to neuron‐like...
Biocompatibility and bioelimination are basic requirements for systematically administered nanomaterials biomedical purposes. Gold-based plasmonic have shown potential applications in photothermal cancer therapy. However, their inability to biodegrade has impeded practical application. In this study, a kind of bioeliminable magnetoplasmonic nanoassembly (MPNA), assembled from an Fe3O4 nanocluster gold nanoshell, was elaborately designed computed tomography, photoacoustic magnetic resonance...
Abstract Wearable devices are being intensively investigated in an extensive range of applications, particularly the field human motion detection. Herein, a graphene‐modified silk fabric strain sensor is fabricated and its satisfactory performance including high sensibility comfortable fit to body reported. Graphene oxide coated on by vacuum filtration reduced hot press method, which provides obtained with good piezoresistivity more environmentally friendly compared chemical reduction....
Abstract Antibacterial photocatalytic therapy (APCT) is considered to be a potential treatment for administrating antibiotic‐resistant bacteria. However, due the low efficiency and weak ability capture bacteria, it not practically applied. In this work, an organic–metal oxide hybrid semiconductor heterostructure fabricated generation of reactive oxygen species (ROS) kill drug‐resistant The organic semiconductor, perylene diimide (PDI), can self‐assemble on Sn 3 O 4 nanosheets form...
Abstract Sensitive and specific blood-based assays for the detection of pulmonary extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses, particularly in children. Here we report a nanoparticle-enhanced immunoassay read by dark-field microscopy that detects two Mycobacterium virulence factors (the glycolipid lipoarabinomannan its carrier protein) on surface circulating extracellular vesicles. In cohort study 147 hospitalized severely immunosuppressed children...
Abstract A system of poly(lactide‐co‐glycolide)‐methoxy poly(ethylene glycol) (PLGA‐mPEG) nanoparticles is developed to formulate superparamagnetic iron oxides (IOs) for magnetic resonance imaging (MRI). This improves the effects, increases half‐life IOs in circulation, and reduces their side effects. The IO‐loaded PLGA‐mPEG were prepared by a modified water‐in‐oil‐in‐water double‐emulsion technique. Their physicochemical properties characterized various techniques. In vitro IO release...
A novel technique was developed for preparing encoded multicolour microparticles based on the self-assembly of bacteria and conjugated polymer nanoparticles (CPNs) by a very simple time-saving manner. These bacteria-CPNs show multicolor emissions tuning FRET efficiencies among CPNs under single excitation wavelength can be successfully applied cell imaging optical barcoding.
In this paper, highly selective core–shell molecularly imprinted polymers (MIPs) of tadalafil on the surface magnetic nanoparticles (MNPs) were prepared. Three widely used functional monomers 2-(trifluoromethyl) acrylic acid (TFMAA), (AA), and methacrylic (MAA) compared theoretically as candidates for MIP preparation. MIP-coated (MIP-coated MNPs) showed large adsorption capacity, high recognition ability, fast binding kinetics tadalafil. Furthermore, because good properties, MNPs can achieve...
Polarized ferroelectric crystal lithium niobate wafers with different cuts are selected to offer differently charged surfaces. By induction of the mesenchymal stem cells differentiation into osteoblasts on surfaces, specific osteogenic-associated markers assessed and results illustrate that positively wafer surface enhances rBMMSCs osteogenic differentiation. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may...