A5086380959- Genomics and Chromatin Dynamics
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- Plant Stress Responses and Tolerance
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
- Genetic diversity and population structure
- Plant Reproductive Biology
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Microbial Community Ecology and Physiology
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Silk-based biomaterials and applications
- Invertebrate Immune Response Mechanisms
- Fecal contamination and water quality
- Plant nutrient uptake and metabolism
- Insect Resistance and Genetics
- Animal Genetics and Reproduction
- Gut microbiota and health
- Plant Genetic and Mutation Studies
- Enzyme Structure and Function
University of Buenos Aires
2015-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2012-2024
Fundación Ciencias Exactas y Naturales
2014-2024
Institute of Astronomy and Space Physics
2020-2022
National Agricultural Technology Institute
2013
Princeton University
2010-2012
Howard Hughes Medical Institute
2010-2012
National University of Quilmes
2004
Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early work revealed remarkable modularity of enhancers, whereby distinct DNA drive gene expression in defined spatiotemporal domains. Nevertheless, a few reports shown that enhancers function developmental stages, implying be pleiotropic. Here, we studied the activity shavenbaby throughout D. melanogaster development. We found all seven tissues and stages. explored how enhancer pleiotropy is encoded two...
Species of the Drosophila melanogaster species subgroup, including D. simulans, mauritiana, yakuba, and santomea, have long served as model systems for studying evolution. However, studies in these been limited by a paucity genetic transgenic reagents. Here, we describe collection strains generated to facilitate within between species. We many each containing mapped piggyBac transposons an enhanced yellow fluorescent protein (EYFP) gene expressed eyes ϕC31 attP site-specific integration...
Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is that morphological convergence can occur through changes orthologous genes. In some cases of convergence, cis -regulatory generate parallel modifications the expression patterns Our understanding how regions contribute to hampered, usually, by limited global structure evolving Here we examine genetic causes case precise phenotypic between...
Abstract Asr (for ABA, stress, ripening) genes are exclusively found in the genomes of higher plants, and encoded proteins have been localized both to nucleus cytoplasm. However, before mechanisms underlying activity ASR can be determined, role these planta should deciphered. Results from this study suggest that is positioned within signaling cascade interactions among glucose, abscisic acid, gibberellins. Tobacco (Nicotiana tabacum) transgenic lines with reduced levels protein showed...
Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes such evolutionary 'hotspots' are thought to maximally affect phenotype with minimal pleiotropic consequences. This has led suggestion that if a GRN understood sufficient detail, path of may be predictable. repeated loss larval trichomes among Drosophila species shavenbaby (svb) expression. svb also required for development leg trichomes, but...
Abstract Evolutionary analyses have estimated that ∼60% of nucleotides in intergenic regions the Drosophila melanogaster genome are functionally relevant, suggesting regulatory information may be encoded more densely than has been revealed by most functional dissections DNA. Here, we approached this issue through a dissection region gene shavenbaby (svb). Most ∼90 kb large is highly conserved genus Drosophila, though characterized enhancers occupy small fraction region. By analyzing...
Enhancers are regulatory elements of genomes that determine spatio-temporal patterns gene expression. The human genome contains a vast number enhancers, which largely outnumber protein-coding genes. Historically, enhancers have been regarded as highly tissue-specific. However, recent evidence has demonstrated many pleiotropic, with activity in multiple developmental contexts. Yet, the extent and impact pleiotropy remain unexplored. In this study we analyzed active across organs based on...
Riboflavin, an essential cofactor for all organisms, is biosynthesized in plants, fungi and microorganisms. The penultimate step the pathway catalyzed by enzyme lumazine synthase. One of most distinctive characteristics this that it found different species two quaternary structures, pentameric icosahedral, built from practically same structural monomeric unit. In fact, icosahedral structure best described as a capsid twelve pentamers. Despite noticeable difference, active sites are virtually...
Abstract Escherichia coli dynamics in urban watersheds are affected by a complex balance among external inputs, niche modulation and genetic variability. To explore the ecological processes influencing E. spatial patterns, we analyzed its abundance phylogenetic structure water samples from stream network with heterogeneous infrastructure environmental conditions. Our results showed that variables, such as macrophyte coverage, DIN sewerage density, mostly explained abundance. Moreover, main...
Despite considerable progress in recent decades dissecting the genetic causes of natural morphological variation, there is limited understanding how variation within species ultimately contributes to differences. We have studied patterning non-sensory hairs, commonly known as "trichomes," on dorsal cuticle first-instar larvae Drosophila. Most Drosophila produce a dense lawn trichomes, but subset these trichomes were lost D. sechellia and ezoana due entirely regulatory evolution shavenbaby...
The stochastic nature of biochemical processes is a source variability that influences developmental stability. Developmental instability (DI) often estimated through fluctuating asymmetry (FA), parameter deals with within-individual variation in bilateral structures. A relevant goal to shed light on how environment, physiology and genotype relate DI, thus providing more comprehensive view organismal development. Using Drosophila melanogaster isogenic lines, we investigated the effect...