A5055629026- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Supramolecular Self-Assembly in Materials
- Photoacoustic and Ultrasonic Imaging
- Fullerene Chemistry and Applications
- ATP Synthase and ATPases Research
- Immune cells in cancer
- Virus-based gene therapy research
- Bone Tissue Engineering Materials
- Microtubule and mitosis dynamics
National Center for Nanoscience and Technology
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2016-2025
Hebei University
2012-2025
Guangzhou Medical University
2019-2025
Southern Medical University
2024
Second Affiliated Hospital of Guangzhou Medical University
2019-2024
State Key Laboratory of Respiratory Disease
2019-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over larger in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, tumors mice. Au@tiopronin have tunable sizes from 2 to 15 with identical surface coatings tiopronin charge were successfully prepared. For monolayer the NPs, more AuNPs found each cell. In addition, accumulation Au NPs ex vivo model was size-dependent: able penetrate...
Although a multitude of promising anti-cancer drugs have been developed over the past 50 years, effective delivery to diseased cells remains challenge. Recently, nanoparticles used as drug vehicles due their high efficiencies and possibility circumvent cellular resistance. However, lack biocompatibility inability engineer spatially addressable surfaces for multi-functional activity an obstacle widespread use. Here we present novel carrier system based on self-assembled, DNA origami...
Development of nanotechnology calls for a comprehensive understanding the impact nanomaterials on biological systems. Autophagy is lysosome-based degradative pathway which plays an essential role in maintaining cellular homeostasis. Previous studies have shown that nanoparticles from various sources can induce autophagosome accumulation treated cells. However, underlying mechanism still not clear. Gold (AuNPs) are one most widely used and been reported to accumulation. In this study, we...
Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells. Polyacrylamide gel electrophoresis measurements of siRNA confirmed the occurrence charge-reversal property nanoparticles. The expression efficiency enhanced green fluorescent protein (EGFP) was improved adjuvant transfection with nanoparticles, which also had much lower toxicity cell proliferation. Lamin A/C, an...
The aim of this study was to determine the size-dependent penetration ability gold nanoparticles and potential application ultrasmall for intranucleus delivery therapy. We synthesized with diameters 2, 6, 10, 16 nm compared their intracellular distribution in MCF-7 breast cancer cells. Nanoparticles smaller than 10 (2 6 nm) could enter nucleus, whereas larger ones (10 were found only cytoplasm. then investigated possibility using 2 as carriers nuclear a triplex-forming oligonucleotide (TFO)...
Correlation of the surface physicochemical properties nanoparticles with their interactions biosystems provides key foundational data for nanomedicine. We report here systematic synthesis 2, 4, and 6 nm core gold (AuNP) featuring neutral (zwitterionic), anionic, cationic headgroups. The cellular internalization these AuNPs was quantified, providing a parametric evaluation charge size effects. Contrasting behavior observed systems: zwitterionic anionic particles, uptake decreased increasing...
Nanomaterials offer opportunities to construct novel compounds for many different fields. Applications include devices energy, including solar cells, batteries, and fuel health, contrast agents mediators photodynamic therapy hyperthermia. Despite these promising applications, any new class of materials also bears a potential risk human health the environment. The advantages innovations must be thoroughly compared against risks evaluate each nanomaterial. Although nanomaterials are often used...
A new type of metabolizable and efficient radiosensitizer for cancer radiotherapy is presented in this study by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The nano-construct (GSH-coated Au25 NCs) inherits attractive features both the core (strong radiosensitizing effect) GSH shell (good biocompatibility). It can preferentially accumulate tumor via improved EPR effect, which leads to strong enhancement radiotherapy. After...
Nanoparticles offer potential as drug delivery systems for chemotherapeutics based on certain advantages of molecular drugs. In this study, we report that particle size exerts great influence the penetration and retention behavior nanoparticles entering tumors. On comparing gold-coated Au@tiopronin were prepared with identical coating surface properties, found 50 more effective in all vitro, ex vivo, vivo assays conducted using MCF-7 breast cells a model system. Beyond superior cultured cell...
The abuse of traditional antibiotics has caused a series health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) flavonoid glycosides: nanoparticles (NPs) nanofibers (NFs), were both mainly governed by electrostatic hydrophobic interactions. These nanostructures...
Abstract New strategies with high antimicrobial efficacy against multidrug-resistant bacteria are urgently desired. Herein, we describe a smart triple-functional nanostructure, namely TRIDENT (Thermo-Responsive-Inspired Drug-Delivery Nano-Transporter), for reliable bacterial eradication. The robust antibacterial effectiveness is attributed to the integrated fluorescence monitoring and synergistic chemo-photothermal killing. We notice that temperature rises generated by near-infrared...