A5007556918- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Antimicrobial Resistance in Staphylococcus
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Bacterial biofilms and quorum sensing
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Fungal Biology and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Bioactive Natural Diterpenoids Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Prostate Cancer Treatment and Research
- Natural product bioactivities and synthesis
- Muscle activation and electromyography studies
- MicroRNA in disease regulation
- Molecular Sensors and Ion Detection
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
Fourth Hospital of Hebei Medical University
2021-2024
Shanghai Jiao Tong University
2008-2024
Hebei Medical University
2009-2024
Fudan University
2024
Renji Hospital
2016-2024
Xi'an Jiaotong University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
First Affiliated Hospital of Hebei Medical University
2009-2024
Shanghai Clinical Research Center
2024
Mudanjiang Medical University
2018-2024
The aim of this study was to determine the size-dependent penetration ability gold nanoparticles and potential application ultrasmall for intranucleus delivery therapy. We synthesized with diameters 2, 6, 10, 16 nm compared their intracellular distribution in MCF-7 breast cancer cells. Nanoparticles smaller than 10 (2 6 nm) could enter nucleus, whereas larger ones (10 were found only cytoplasm. then investigated possibility using 2 as carriers nuclear a triplex-forming oligonucleotide (TFO)...
Nucleic acids in biofluids are emerging biomarkers for the molecular diagnostics of diseases, but their clinical use has been hindered by lack sensitive detection assays. Herein, we report development a nucleic acid assay named SPOT (sensitive loop-initiated DNAzyme biosensor detection) rationally designing catalytic endonuclease capability into unified one-stranded allosteric biosensor. is activated once target specific sequence binds to its module enable continuous cleavage reporters....
Abstract Crack assessment has remained one of the high‐priority research topics for structural health monitoring. However, current mainly focuses on crack at some point, but pays relatively less attention to long‐term development cracks, which is important structure In this paper, a new method based dual‐convolutional neural network (CNN) (well over 94% accuracy), digital image processing technology and shape context proposed, achieves fully automated process composed detection, measurement,...
Cellular senescence, a process that arrests the cell cycle, is cellular response mechanism for various stresses and implicated in aging age-related diseases. However, understanding of senescence living organisms insufficient, largely due to scarcity sensitive tools detection
Micro-RNA (miRNA) emerges as a promising type of biomarker for cancer diagnosis. There is an urgent need developing rapid, convenient, and precise miRNA detection methods that may be conducted with limited laboratory facilities, especially in underdeveloped areas. Herein, we developed method termed miRoll-Cas, where first amplified by rolling circle transcription then subject to CRISPR-Cas13a assay. Using realized the sensitive multiple cancer-relevant markers (miR21, miR141, Let7b)...
Epidemiological data imply links between the increasing incidences of Alzheimer's disease (AD) and type 2 diabetes mellitus. In this study, an AD rat model was established by combining treatments with intracerebroventricular streptozotocin (icv-STZ) subcutaneous D-galactose, effects curcumin on depressing AD-like symptoms were investigated. group, rats treated icv-STZ in each hippocampus 3.0 mg/kg bodyweight once then subcutaneously injected D-galactose daily (125 bodyweight) for 7 weeks....
Detection of cellular senescence is important not only in the study various biological systems, but also practical applications such as image-guided surgical removal senescent cells, well monitoring drug-responsiveness during cancer therapies. Due to lack suitable imaging probes for detection, particularly living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated...
Background and Purpose Methyl salicylate 2‐ O ‐β‐ d ‐lactoside ( MSL ), whose chemical structure is similar to that of salicylic acid, a natural product derivative isolated from traditional Chinese herb. The aim this study was investigate the therapeutic effect in mice with collagen‐induced arthritis CIA ) explore its underlying mechanism. Experimental Approach anti‐arthritic effects were evaluated on human rheumatoid fibroblast‐like synoviocytes FLS vitro vivo by obtaining clinical scores,...
Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in United States and are on a global rise. However, what defines particularly CA-MRSA lineages poorly understood. Threatening vast population, predominant Asian lineage ST59 major epidemiological importance. there have been no molecular analyses using defined gene deletion mutants that...
Staphylococcus aureus (S. aureus) is an important pathogen of humans and livestock species, but understanding the clonal distribution S. causing different host-species infections in same geographical environment within period lacking. By characterizing caused by bovine, pediatric, adult patients Shanghai, China, between 2012 2014, we identified methicillin-sensitive (MSSA) ST188 as major lineage multiple host species. Whole-genome sequencing phenotypic analyses demonstrated that might evolve...
Abstract Backgroud With the reform of medical system in China, Beijing municipal hospitals explored a new pharmaceutical care model and set up medication therapy management services (MTMs) ambulatory since 2019. We were one first to this service China. At present, there relatively few reports about effect MTMs In study, we summarized implementation our hospital, explore feasibility pharmacist-led impact on patients’ costs. Methods A retrospective study was conducted university-affiliated,...