A5101530093- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Pickering emulsions and particle stabilization
- Luminescence Properties of Advanced Materials
- Immune Cell Function and Interaction
- Advanced Photocatalysis Techniques
- Advanced Drug Delivery Systems
- Proteins in Food Systems
- Electrocatalysts for Energy Conversion
- Micro and Nano Robotics
- SARS-CoV-2 and COVID-19 Research
- Perovskite Materials and Applications
- Bacteriophages and microbial interactions
- MXene and MAX Phase Materials
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- 2D Materials and Applications
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Radiation Detection and Scintillator Technologies
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Metabolomics and Mass Spectrometry Studies
University of Chinese Academy of Sciences
2014-2024
Institute of Process Engineering
2014-2024
Southeast University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Chinese Academy of Sciences
2020-2024
China University of Geosciences (Beijing)
2015-2019
China Minmetals (China)
2019
Soochow University
2016-2018
Mineral Resources
2015-2016
Suzhou Research Institute
2016
Abstract For rapid response against the prevailing COVID‐19 (coronavirus disease 19), it is a global imperative to exploit immunogenicity of existing formulations for safe and efficient vaccines. As most accessible adjuvant, aluminum hydroxide (alum) still sole employed adjuvant in countries. However, alum tends attach on membrane rather than entering dendritic cells (DCs), leading absence intracellular transfer process antigens, thus limits T‐cell‐mediated immunity. To address this, packed...
Abstract A major challenge in vaccine delivery is to achieve robust lymph‐node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines LNs stimulate the onset persistence of adaptive immune responses. Previous attempts at developing systems have focused sizes, charges, or surface ligands but not their deformability. In fact, LN homing antigen‐presenting cells depends deformability pass through cellular gaps. Herein, albumin‐stabilized emulsions engineered. Owing...
Abstract The rational design of drug delivery systems has led to enhanced targeting, increased efficiency, and a reduction side effects in chemotherapies vaccines. As most biological reactions took place at the interface, particle‐stabilized emulsion (Pickering emulsion), may offer major implications for advanced loading, delivery, controlled release. In fact, it is aggregating particles that determined multi‐level structure, multi‐valent cellular interactions, multi‐functional...
Messenger RNA (mRNA) has emerged as an innovative therapeutic modality, offering promising avenues for the prevention and treatment of a variety diseases. The tremendous success mRNA vaccines in effectively combatting coronavirus disease 2019 (COVID-19) evidences unlimited medical potential technology. Overcoming challenges related to stability, immunogenicity, precision targeting been made possible by recent advancements lipid nanoparticles (LNPs). This review summarizes state-of-the-art...
A novel green phosphor Ca<sub>6</sub>La<sub>4</sub>(SiO<sub>4</sub>)<sub>2</sub>(PO<sub>4</sub>)<sub>4</sub>O<sub>2</sub>:Eu<sup>2+</sup> that fabricated with commercial blue and red coating on a n-UV chip.
The substitution of La<sup>3+</sup> by Ca<sup>2+</sup> in a series phosphors led to crystal structure variation and the emitted color changing from green blue.
Thickness-controlled uniform MoS<sub>2</sub> films are grown by polymer-assisted deposition approach from 50 nm to 2.5 nm, corresponding bandgaps modulated 1.50 eV 1.64 eV. The photoresponse test demonstrates as-grown has fast response light.
Abstract Current methods for intracellular protein analysis mostly require the separation of specific organelles or changes to environment. However, functions proteins are determined by their native microenvironment as they usually form complexes with ions, nucleic acids, and other proteins. Here, we show a method in situ cross-linking mitochondrial living cells. By using poly(lactic-co-glycolic acid) (PLGA) nanoparticles functionalized dimethyldioctadecylammonium bromide (DDAB) deliver...
Abstract Many candidate anticancer drugs have suffered from their intrinsic hydrophobicity, which poses several obstacles for clinical application. To overcome this challenge and further improve the performance, herein a nanocrystal‐based biomimetic formulation with sandwich structure is developed. As core, flake shaped nanocrystals (NCs) high loading of hydrophobic drug hydroxycamptothecin (HCPT) are synthesized via mild nanoprecipitation process by exploring template effect serum albumin....
Abstract Developing highly efficient electrocatalysts for hydrogen generation from water has been a crucial option future energy conversion and storage. Rhenium dichalcogenides (ReX 2 , X=S or Se) have attracted tremendous research interests due to their unique distorted‐1T phase anisotropic electronic structure. So far, there is no report about S doped ReSe electrocatalyst. In this work, we present three‐dimensional nanosheets electrocatalyst derived sulfur‐doped rhenium selenide (ReSe...
Biomolecules such as nucleic acids and proteins can undergo liquid-liquid phase separation to form biomolecular condensates with diverse architectures. However, fundamental questions surrounding the biophysical principles that govern condensate architecture their potential biotechnological applications remain unresolved. Here, we report FUS/EWS/TAF15 family fusion oncoprotein FUS-ERG forms hollow co-condensates double-stranded DNA containing GGAA microsatellites. Through a combination of...
As peripheral lymphocytes are typically excluded from the gastrointestinal lymph tissues, current parenteral vaccinations fail to simultaneously induce systemic and mucosal responses. To break natural barrier, "immunoticket" capsules developed heralded, which designed with positive charged shells oily core spatiotemporally deliver antigens all-trans retinoic acid (RA). After intramuscular vaccinations, these function as an immunoticket cultivate dendritic cells (DCs) gut-homing receptors...
Parenteral vaccinations are not able to elicit effective systemic and gastrointestinal immune protection simultaneously because the lymphocytes typically restricted primed tissues. Although all-trans retinoic acid (atRA) was reported trigger gut-homing of immunocytes, bioavailability responses remain limited for use in robust enteric vaccinations. Here, we show that co-delivery atRA, CpG oligodeoxynucleotides (CpG), antigens via engineered polymer/lipid nanoparticles (PLNPs) could exploit...
Raspberry-shaped particles have attracted increasing interest due to their tunable surface morphologies and physicochemical properties. A variety of covalent noncovalent strategies been developed for the fabrication raspberry-shaped particles. However, most these are complex or require precise control solution conditions. In this work, we develop a direct approach microgels. Our strategy works through electrostatically driven heterocoagulation binary microgels with complementary functional...