A5039345750- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Photochromic and Fluorescence Chemistry
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Cellular Mechanics and Interactions
University of Colorado Denver
2024
University of Colorado Anschutz Medical Campus
2022
University of New Mexico
2019-2021
Detection of cellular senescence is important not only in the study various biological systems, but also practical applications such as image-guided surgical removal senescent cells, well monitoring drug-responsiveness during cancer therapies. Due to lack suitable imaging probes for detection, particularly living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated...
Naïve T cell activation in secondary lymphoid organs such as lymph nodes (LNs) occurs upon recognition of cognate antigen presented by presenting cells (APCs). requires cytoskeleton rearrangement and sustained interactions with APCs. Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) proteins are a family cytoskeletal effector responsible for actin polymerization frequently found at the leading edge motile cells. Ena/VASP have been implicated motility adhesion various types, but their...
Lymphocyte trafficking and migration through tissues is critical for adaptive immune function and, to perform their roles, T cells must be able navigate diverse tissue environments that present a range of mechanical challenges. predominantly express two members the formin family actin effectors, Formin-like 1 (FMNL1) mammalian diaphanous-related (mDia1). While both FMNL1 mDia1 have been studied individually, they not directly compared determine functional differences in promoting cell...
Abstract Naive T cell activation in secondary lymphoid organs such as lymph nodes (LNs) occurs upon recognition of cognate antigens presented by antigen presenting cells (APCs). requires cytoskeleton rearrangement and sustained interactions with APCs. Ena/VASP proteins are a family cytoskeletal effector responsible for actin polymerization frequently found at the leading edge motile cells. have been implicated motility adhesion various types, but their role primary has not explored. Our goal...
Abstract Hydrolases are important molecules that involved in a wide range of biological functions and their activities tightly regulated healthy or diseased states. Detecting imaging the hydrolases, therefore, can reveal underlying molecular mechanisms context cells to organisms, correlation with different physiological conditions therefore be used diagnosis. Due nature substrate-based probes activated catalytic cycles, cleavage covalent bonds frees reporter moieties. For test-tube type bulk...