A5100380084- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bacteriophages and microbial interactions
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Magnesium Alloys: Properties and Applications
- Plasmonic and Surface Plasmon Research
- Extracellular vesicles in disease
- RNA modifications and cancer
- Plant Water Relations and Carbon Dynamics
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- DNA and Biological Computing
- Aluminum Alloys Composites Properties
- Biological Activity of Diterpenoids and Biflavonoids
- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Proteoglycans and glycosaminoglycans research
- Hydrogen Storage and Materials
Shanghai Jiao Tong University
2016-2025
Shanghai University
2022-2025
China Pharmaceutical University
2023-2025
Guiyang Medical University
2023-2025
Affiliated Hospital of Guizhou Medical University
2023-2025
Chengdu Third People's Hospital
2025
Chongqing Medical University
2011-2024
CompuTherm (United States)
2015-2024
Gansu Provincial Maternal and Child Health Hospital
2021-2024
China University of Mining and Technology
2023-2024
Cancer cells in hypoxic tumors are remarkably resistant to photodynamic therapy. Here, we hypothesize that an oxygen and Pt(II) self-generating multifunctional nanocomposite could reverse the hypoxia-triggered PDT resistance. The contains Pt(IV) chlorin e6, which upconversion nanoparticles loaded convert 980 nm near-infrared light into 365 660 emissions. Upon accumulation at tumor site, a laser is used trigger generate O2 for consumption process produce cytotoxic reactive species. composite...
Spherical nucleic acid (SNA) nanoparticle conjugates are a class of bionanomaterials that extremely potent in many biomedical applications. Their unique ability to enter multiple mammalian cell types as single-entity agents arises from their novel three-dimensional architecture, which consists dense shell highly oriented oligonucleotides chemically attached typically gold core. This architecture allows SNAs engage certain surface receptors facilitate entry. Here, we report studies aimed at...
A macrophage exosome coated nanoplatform for targeted chemotherapy of triple-negative breast cancer.
Abstract Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐grafted polycaprolactone (DNA‐ g ‐PCL) brushes form spherical and nanosized hydrogels via nucleic acid hybridization in which small interfering RNAs (siRNAs) fully embedded protected for systemic delivery. Owing existence multivalent mutual crosslinking events inside, crosslinked nanogels with tunable size exhibit not only good thermostability, but also remarkable physiological stability that can...
Immunotherapy is recognized as one of the most promising approaches to treat cancers. However, its effect in glioblastoma (GBM) treatment insufficient, which can part be attributed immunosuppressive tumor microenvironment (TME). Microglia and macrophages are main immune infiltrating cells TME GBM. Unfortunately, instead initiating anti-tumor response, GBM-infiltrating microglia switch a tumor-promoting phenotype (M2), support growth, angiogenesis, immunosuppression by release cytokines. In...
Packaging multiple drugs into a nanocarrier with rational design to achieve synergistic cancer therapy remains challenge due the intrinsically varied pharmacodynamics of therapeutic agents. Especially difficult is combining small-molecule and macromolecular biologics. Here, we successfully graft pheophorbide A (PPA) photosensitizers on DNA backbone at predesigned phosphorothioate modification sites. The synthesized four PPA-grafted DNAs are assembled tetrahedron framework, which further...
<h3>Importance</h3> The lack of experienced ophthalmologists limits the early diagnosis retinal diseases. Artificial intelligence can be an efficient real-time way for screening <h3>Objective</h3> To develop and prospectively validate a deep learning (DL) algorithm that, based on ocular fundus images, recognizes numerous diseases simultaneously in clinical practice. <h3>Design, Setting, Participants</h3> This multicenter, diagnostic study at 65 public medical centers hospitals 19 Chinese...
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Plastic products in plant production and protection help farmers increase crop production, enhance food quality, reduce global water use their environmental footprint. Simultaneously, plastic has emerged as a critical ecological issue recent years, its pollution significantly impacted soil, water, plants. Thus, this review examines the multifaceted problems of agriculture risk to security, ecosystem, environment. The study’s objective was present most information on using different...
Nucleic acids in biofluids are emerging biomarkers for the molecular diagnostics of diseases, but their clinical use has been hindered by lack sensitive detection assays. Herein, we report development a nucleic acid assay named SPOT (sensitive loop-initiated DNAzyme biosensor detection) rationally designing catalytic endonuclease capability into unified one-stranded allosteric biosensor. is activated once target specific sequence binds to its module enable continuous cleavage reporters....
Molecular self-assembly is a promising approach to the preparation of nanostructures. DNA, in particular, shows great potential be superb molecular system. Synthetic DNA molecules have been programmed assemble into wide range It generally believed that rigidities nanomotifs (tiles) are essential for programmable well defined Recently, we shown adequate conformational flexibility could exploited assembling 3D objects, including tetrahedra, dodecahedra, and buckyballs, out three-point star...
MafB is a member of the large Maf family transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains. Although it well known specifically expressed in glomerular epithelial cells (podocytes) macrophages, characterization null mutant phenotype these tissues has not been previously reported. To investigate suspected functions kidney we generated mafB/green fluorescent protein (GFP) knock-in mice. homozygous mutants displayed renal...
Epsilon-near-zero behavior and an optically metallic response are predicted using electrodynamics simulations in superlattices comprising silver nanoparticles. Programmable DNA-mediated assembly is used to synthesize both binary silver–gold nanoparticle superlattices, which characterized small-angle X-ray scattering, transmission electron microscopy, elemental mapping. As a service our authors readers, this journal provides supporting information supplied by the authors. Such materials peer...
Abstract Based on their structural similarity to natural nucleobases, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid‐phase synthesis. By elaborately designing sequences, floxuridine‐integrated synthesized and self‐assembled well‐defined polyhedra with definite drug‐loading ratios as well tunable size morphology. As a novel drug delivery system, these drug‐containing could ideally mimic the Trojan Horse deliver chemotherapeutics tumor cells fight...
Most chemotherapeutics are hydrophobic molecules and need to be converted into hydrophilic form before administration. Based on the excellent hydrophilicity programmability of DNA, now, a general strategy construct precise drug-containing DNA framework for cancer treatment is reported. In this novel drug delivery system, carbonethyl bromide-modified camptothecin (CPT) employed directly react with phosphorothioate (PS) modified DNAs, resulting in formation chemotherapeutics-grafted DNAs...
Significance DNA-programmable methods provide unprecedented control over the assembly of nanoparticles into complex structures, including superlattices with deliberately tailorable compositions, crystal symmetries, lattice constants, and habits. In principle, such bottom-up approaches can be used to assemble interesting photonic ones containing quantum dots metal nanoparticles. Herein we show that tune interaction between light collective electronic modes gold by independently adjusting...
We report the large-area assembly of anisotropic gold nanoparticles into lithographically defined templates with control over their angular position using a capillary force-based approach. elucidate role geometry in consisting different shapes and sizes. These insights allow us to design that immobilize individual triangular nanoprisms concave nanocubes shape-selective manner filter undesired impurity particles from mixture prisms other polyhedra. Furthermore, by studying two same template,...
DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With compact architecture that embeds functional inside, the self-assembled can efficiently enter cells and knock down target gene expression, making them potential noncationic vectors nucleic acid