A5100402715- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Membrane Separation Technologies
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Advanced oxidation water treatment
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Nanocluster Synthesis and Applications
- Sulfur Compounds in Biology
- Streptococcal Infections and Treatments
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Circular RNAs in diseases
- Molecular Sensors and Ion Detection
- Carbon and Quantum Dots Applications
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
Zunyi Medical University
2020-2025
Southwest Medical University
2025
First Affiliated Hospital Zhejiang University
2022-2025
Fudan University
2020-2025
Cornell University
2024
Weill Cornell Medicine
2024
Wuhan Institute of Physics and Mathematics
2017-2024
Wuhan National Laboratory for Optoelectronics
2024
Chinese Academy of Sciences
2017-2024
University of Chinese Academy of Sciences
2024
TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent receptor-stimulated activation of this provides high protection from several common autoimmune diseases but without immunodeficiency. An agent that recapitulates the phenotype may therefore represent an important advancement treatment autoimmunity. BMS-986165 potent oral similarly blocks allosterically with selectivity potency afforded...
A macrophage exosome coated nanoplatform for targeted chemotherapy of triple-negative breast cancer.
Uncontrolled bleeding and infection can cause significant increases in mortalities. Hydrogel sealants have attracted extensive attention for their ability to control bleeding. However, because interfacial water is a formidable barrier strong surface bonding, challenge remains finding product that offers robust tissue adhesion combined with anti-infection properties. Inspired by the adhesive mechanism of biofilm mussels, we report novel dual bionic hydrogel (DBAH) based on chitosan grafted...
Immunotherapy is recognized as one of the most promising approaches to treat cancers. However, its effect in glioblastoma (GBM) treatment insufficient, which can part be attributed immunosuppressive tumor microenvironment (TME). Microglia and macrophages are main immune infiltrating cells TME GBM. Unfortunately, instead initiating anti-tumor response, GBM-infiltrating microglia switch a tumor-promoting phenotype (M2), support growth, angiogenesis, immunosuppression by release cytokines. In...
A series of dimeric compounds based on the AVPI motif Smac were designed and prepared as antagonists inhibitor apoptosis proteins (IAPs). Optimization cellular potency, physical properties, pharmacokinetic parameters led to identification compound 14 (AZD5582), which binds potently BIR3 domains cIAP1, cIAP2, XIAP (IC50 = 15, 21, 15 nM, respectively). This causes cIAP1 degradation induces in MDA-MB-231 breast cancer cell line at subnanomolar concentrations vitro. When administered...
Abstract Separation and purification on molecular level from organic solvent mixtures are of paramount importance in industries. Organic nanofiltration (OSN) is a pressure‐driven membrane separation process providing an attractive alternative to conventional energy‐intensive technologies. However, devising stable, scalable with high permeability excellent selectivity still challenge. Interfacially polymerized thin‐film composite (TFC) OSN membranes integrating ultrathin selective layer...
The edge sites of MoS2 are catalytically active for the hydrogen evolution reaction (HER), and growing monolayer structures that edge-rich is desirable. Here, we show production large-area highly branched dendrites on amorphous SiO2/Si substrates using an atmospheric pressure chemical vapor deposition explore their use in electrocatalysis. By tailoring substrate construction, evolves from triangular to dendritic morphology because change growth conditions. rough edges endow with a fractal...
Membranes with strong solvent resistance and efficient molecular separation are desirable in industries. Especially the fractionation of organic molecules harsh solvents still remains a challenge pharmaceutical industry. Here, we report flexible aliphatic–aromatic polyamide thin-film composite (TFC) membrane high stability, permeability, precise selectivity mild as well polar aprotic solvents. This nanofiltration (OSN) integrates cross-linked sub-100 nm nanofilm nanofibrous sublayer. The...
Herein, we developed hybrid DNAzyme nanoparticles (NPs) to achieve light-induced carrier-free self-delivery of DNAzymes with sufficient cofactor supply and lysosome escape capacity. In this system, aggregation-induced emission (AIE) photosensitizer (PS) (TBD-Br) was grafted onto a phosphorothiolated backbone, which automatically self-assembled form NPs the surface phosphorothioate group could easily coordinate Zn2+ in buffer. When yielded were located inside tumor cell lysosomes, 1O2 from...
The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe
Flux and antifouling properties of mixed matrix membranes (MMMs) are yet to attain satisfactory status. The objective this study is find a method for mitigating the biofouling poly(ether sulfone) (PES) ultrafiltration via blending thermoexfoliated vermiculite (VMT). Flow cytometry analysis shows that behaviors Bacillus subtilis 168 as Gram-positive bacterium Escherichia coli DH5 alpha Gram-negative were different. Hence, cell property suspected contributory factor in biofilm formation....
Abstract Autophagy plays critical roles in airway inflammation and fibrosis-mediated remodeling many factors including proinflammatory cytokines related pathways are involved the process. The aim of present study was to examine role epithelial microRNAs (miRNAs) autophagy-mediated identify underlying mechanisms. Serum miR-34/449, inflammatory factors, autophagy fibrosis-related proteins were determined by real-time PCR, enzyme-linked immunosorbent assay western blotting 46 subjects with...
Abstract Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade, remains difficult to treat. Furthermore, molecular mechanisms underlying its development are still unclear. In this study, bioinformatics analysis showed that MELK was highly expressed lung negatively correlated survival adenocarcinoma (LUAD). Immunohistochemistry LUAD patient tissues revealed there were high level expression LUAD. Knockdown inhibits migration invasion cells, which may be mediated...
Abstract Exosomal microRNAs (miRNAs) are important biomarkers for clinical diagnosis and disease treatment monitoring. However, most approaches exosomal miRNA detection time‐consuming, laborious, expensive. Herein, we report a virus‐mimicking fusogenic vesicle (Vir‐FV) that enables rapid, efficient, high‐throughput of miRNAs within 2 h. Fusogenic proteins on Vir‐FVs can specifically target the sialic‐acid‐containing receptors exosomes, inducing efficient fusion exosomes. Upon content mixing,...