A5082474292- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Alcohol Consumption and Health Effects
- Gastric Cancer Management and Outcomes
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Eosinophilic Esophagitis
- Gout, Hyperuricemia, Uric Acid
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Gastrointestinal disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Drug Transport and Resistance Mechanisms
- Microscopic Colitis
Zhejiang University
2016-2025
First Affiliated Hospital Zhejiang University
2015-2025
St. Jude Children's Research Hospital
2024
Soochow University
2023
Ruihua Affiliated Hospital of Soochow University
2023
National Clinical Research Center for Digestive Diseases
2022
Beijing Institute of Graphic Communication
2022
Second Affiliated Hospital of Zhejiang University
2020-2022
First Hospital of Jiaxing
2020
Blood Center of Zhejiang Province
2017-2018
MicroRNA-34a (miR-34a) is thought to be involved in nonalcoholic fatty liver disease (NAFLD). However, the association between altered expression of miR-34a and pathophysiological features NAFLD remains unclear. Here, we investigated mechanisms by which influences through PPARα-related pathway. Real-time quantitative PCR, western blotting other assays kit were used investigate function an model. Cultured cells transfected with inhibitor C57BL/6 mice injected vein tail conducted for effects...
Magnifying endoscopy with narrow band imaging (M-NBI) has been applied to examine early gastric cancer by observing microvascular architecture and microsurface structure of mucosal lesions. However, the diagnostic efficacy non-experts in differentiating from non-cancerous lesions M-NBI remained far satisfactory. In this study, we developed a new system based on convolutional neural network (CNN) analyze observed M-NBI.A total 386 images 1702 were collected train establish CNN model...
Background and Aims: Early identification of modifiable risk factors is essential for the prevention nonalcoholic fatty liver disease (NAFLD). We aimed to systematically explore relationships between genetically predicted NAFLD. Approach Results: applied univariable multivariable Mendelian randomization analyses 35 also evaluated combined results in three independent large genome‐wide association studies. Genetically alcohol frequency, elevated serum levels enzymes, triglycerides, C‐reactive...
Despite years of effort, exact pathogenesis nonalcoholic fatty liver disease (NAFLD) remains obscure. To gain an insight into the regulatory roles microRNAs (miRNAs) in aberrant energy metabolic status and NAFLD, we analyzed expression miRNAs livers ob/ob mice, streptozotocin (STZ)-induced type 1 diabetic normal C57BL/6 mice by miRNA microarray. Compared with showed upregulation eight downregulation four livers. Upregulation miR-34a miR-122 was found STZ-induced mice. These results...
The precise prevalence and risk factors for the development of nonalcoholic fatty liver disease (NAFLD) in nonobese adults remains unclear. objective this study was to investigate NAFLD its a Chinese population.We firstly investigated associated with presence (body mass index (BMI) <25 kg/m(2)) subjects via cross-sectional study, then analyzed subsequent prospective 5-year follow-up same population.A total 6,905 were enrolled study. Baseline evaluation revealed that 7.27%. A 5,562 who free...
Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic disease, and serum uric acid observed to be significantly elevated in NAFLD patients. However, whether this elevation causal, bystander, or consequence remains unclear. We performed population-based prospective study among the employees Zhenhai Refining & Chemical Company Ltd., Ningbo, China investigate has casual role for NAFLD. A total 6890 initially NAFLD-free subjects were followed up 3 years. Overall, 11.80% (813/6890)...
Objective Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading to non-alcoholic liver disease (NAFLD). This study aimed investigate the underlying mechanisms by which FFA contributes pathogenesis NAFLD via regulation 3-mercaptopyruvate sulfurtransferase (MPST), a key enzyme that regulates endogenous hydrogen sulfide (H 2 S) biosynthesis. Design Hepatic MPST expression was evaluated mice and patients with NAFLD. A variety molecular approaches were used effects...
To identify hepatocellular carcinoma (HCC)‐implicated long noncoding RNAs (lncRNAs), we performed an integrative omics analysis by integrating mRNA and lncRNA expression profiles in HCC tissues. We identified a collection of candidate HCC‐implicated lncRNAs. Among them, demonstrated that lncRNA, which is named as p53‐stabilizing activating RNA ( PSTAR ), inhibits cell proliferation tumorigenicity through inducing p53‐mediated cycle arrest. further revealed can bind to heterogeneous nuclear...
Leukocyte cell–derived chemotaxin 2 (LECT2) is a multifunctional cytokine and reduced plasma levels were found in patients with sepsis. However, precise functions mechanisms of LECT2 remain unclear. The aim the present study was to determine role modulating immune responses using mouse sepsis models. We that treatment improved outcome mice bacterial Macrophages (MΦ), but not polymorphonuclear neutrophils, mediated beneficial effect on could alter gene expression enhance phagocytosis killing...
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases. Machine learning techniques were introduced to evaluate optimal predictive clinical model NAFLD.A cross-sectional study was performed with subjects who attended a health examination at First Affiliated Hospital, Zhejiang University. Questionnaires, laboratory tests, physical examinations, and ultrasonography employed. then implemented using open source software Weka. The tasks included feature selection...
Abstract Non-alcoholic fatty liver disease (NAFLD) is an important health issue worldwide. We aimed to develop a simple model determine the presence of NAFLD in Chinese population. A cross-sectional study with 9602 subjects was conducted. Potential predictors were entered into stepwise logistic regression analysis obtain model. used 148 patients biopsy validate this The model, named ZJU index, developed based on body mass index (BMI), fasting plasma glucose (FPG), triglycerides (TG) and...
Allyl isothiocyanate (AITC), a classic anti-inflammatory and antitumorigenic agent, was recently identified as potential treatment for obesity insulin resistance. However, little is known about its direct impact on the liver.To investigate effect underlying mechanism of AITC in nonalcoholic fatty liver disease (commonly referred to NAFLD).To establish mouse cellular model NAFLD, C57BL/6 mice were fed high fat diet (HFD) 8 wk, AML-12 cells treated with 200 μM palmitate acid 24 h. For...
Abstract Nuclear factor erythroid 2-related 2 (NRF2) is a transcription responsible for mounting an anti-oxidation gene expression program to counter oxidative stress. Under unstressed conditions, Kelch-like ECH-associated protein 1 (KEAP1), adaptor CUL3 E3 ubiquitin ligase, mediates NRF2 ubiquitination and degradation. We show here that the deubiquitinase USP25 directly binds KEAP1 prevents KEAP1’s own In absence of Usp25 or if DUB inhibited, downregulated stabilized, allowing cells respond...
Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions human disease. In this study, we investigated the expression of eight members family colon cancer identified potential tumor development progression. Antibodies against were prepared by immunizing rabbits with synthetic peptides derived from sequences members. Then constructed a tissue microarray...