A5100459278- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Traffic control and management
- Photodynamic Therapy Research Studies
- Nonmelanoma Skin Cancer Studies
- Transportation Planning and Optimization
- Vehicular Ad Hoc Networks (VANETs)
- Vehicle emissions and performance
- Advanced Photocatalysis Techniques
- Iron oxide chemistry and applications
- Extracellular vesicles in disease
- Cancer and Skin Lesions
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Gold and Silver Nanoparticles Synthesis and Applications
- Ferroelectric and Negative Capacitance Devices
- Microwave Imaging and Scattering Analysis
- Geophysical Methods and Applications
- Advancements in Battery Materials
- Skin Protection and Aging
- Cancer Research and Treatments
- Ultrasonics and Acoustic Wave Propagation
- Opportunistic and Delay-Tolerant Networks
- Photoacoustic and Ultrasonic Imaging
- Cutaneous Melanoma Detection and Management
Tongji University
2019-2025
Technical Institute of Physics and Chemistry
2020-2025
Chinese Academy of Sciences
2020-2025
Shanghai Skin Disease Hospital
2019-2024
Jilin University
2017-2024
Qingdao University
2023-2024
Shandong University
2024
Hebei Medical University
2020-2024
University of Science and Technology of China
2023-2024
Shanghai Electric (China)
2024
Therapeutic interventions of hepatic ischemia-reperfusion injury to attenuate liver dysfunction or multiple organ failure following surgery and transplantation remain limited. Here we present an innovative strategy by integrating a platinum nanoantioxidant inducible nitric oxide synthase into the zeolitic imidazolate framework-8 based hybrid nanoreactor for effective prevention injury. We show that can scavenge excessive reactive oxygen species at site meanwhile generate subsequent synthesis...
Objective Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading to non-alcoholic liver disease (NAFLD). This study aimed investigate the underlying mechanisms by which FFA contributes pathogenesis NAFLD via regulation 3-mercaptopyruvate sulfurtransferase (MPST), a key enzyme that regulates endogenous hydrogen sulfide (H 2 S) biosynthesis. Design Hepatic MPST expression was evaluated mice and patients with NAFLD. A variety molecular approaches were used effects...
Cancer nanotheranostics, integrating both diagnostic and therapeutic functions into nanoscale agents, are advanced solutions for cancer management. Herein, a light-responsive biodegradable nanorattle-based perfluoropentane-(PFP)-filled mesoporous-silica-film-coated gold nanorod (GNR@SiO2 -PFP) is strategically designed prepared enhanced ultrasound (US)/photoacoustic (PA) dual-modality imaging guided photothermal therapy of melanoma. The as-prepared nanorattles composed thin mesoporous silica...
To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate preparation process. These issues less concern if nanocarrier itself has most functions. In this work, poly(ethylene glycol)-boron dipyrromethene amphiphile (PEG-F54 -BODIPY) with 54 fluorine-19 (19 F) is synthesized employed to emulsify...
Development of stimuli-responsive theranostics is great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as theranostic agents multimodal imaging chemo-photothermal combination therapy. The Bi-BSA NRs synthesized in aqueous phase via a facile reduction method using Bi2O3 nanospheres the sacrificial template. morphology, biocompatibility, photothermal effect, drug loading/releasing abilities,...
A novel covalent organic framework polymer material that bears conjugated anthraquinone and triazine units in its skeleton has been prepared via a facile one-pot condensation reaction employed as an anode for Li-ion batteries. The consist of C═N groups, C═O benzene which enable 17-electron redox with Li per repeating unit bring theoretical specific capacity 1450 mA h g-1. also shows large surface area hierarchically porous structure to trigger interfacial storage contribute additional...
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single modality, and higher therapeutic efficiency one or their simple “mechanical” combination. Herein, we report a dual‐stimuli responsive nanotheranostic based on hierarchical nanoplatform, composed of mesoporous silica‐coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), 5‐fluorouracil (5‐FU), for in vivo multimodal therapy. The 5‐FU loaded ICG‐conjugated (GNR@SiO2‐5‐FU‐ICG) was able to response...
Gold nanorods (GNRs) have shown great potential applications in cancer theranostics due to the unique phenomenon of surface plasmon resonance, which leads strong electric fields on and consequently enhances absorption scattering near-infrared (NIR) region. Indocyanine green (ICG), an amphipathic dye, is not only excellent NIR imaging agent but also ideal light absorber for laser-mediated photodynamic photothermal therapy. In this study, order integrate merits GNRs ICG biomedical...
Allyl isothiocyanate (AITC), a classic anti-inflammatory and antitumorigenic agent, was recently identified as potential treatment for obesity insulin resistance. However, little is known about its direct impact on the liver.To investigate effect underlying mechanism of AITC in nonalcoholic fatty liver disease (commonly referred to NAFLD).To establish mouse cellular model NAFLD, C57BL/6 mice were fed high fat diet (HFD) 8 wk, AML-12 cells treated with 200 μM palmitate acid 24 h. For...
Heavy metals (HMs) contamination and vegetation destruction in the mining area caused by activities are severely increasing. It is urgent to restore stabilize HMs. In this study, we compared ability of HMs phytoextraction/phytostabilization three dominant plants, including Artemisia argyi (LA), Miscanthus floridulus (LM), Boehmeria nivea (LZ) a lead-zinc Huayuan County (China). We also explored role rhizosphere bacterial community assisting phytoremediation using 16S rRNA sequencing...
Usually, vehicles' stop-and-go driving will consume more fuel and emit CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> than constant speed driving. To reduce emissions, travel should be smoothed by reducing the times. In this paper, a three-tier structure is proposed to realize dynamic traffic light control for smoothing travel. tier-1, an electronic toll collection (ETC) system employed collecting road flow data calculating...
Great enhancement of the second harmonic generation response is achieved in AgHgPS<sub>4</sub>by introducing vacancy defects and highly distorted HgS<sub>4</sub>tetrahedra using AgGaS<sub>2</sub>as template.
Multimodality imaging-guided therapy can improve the diagnostics and therapeutics efficiency of cancer. Herein, we developed a light-responsive nanotheranostic agent based on indocyanine green (ICG) conjugated mesoporous silica coated gold nanobipyramid (GNB@SiO2) (denoted as GNB@SiO2-ICG) for simultaneous fluorescence (FL)/photoacoustic (PA) photothermal (PTT). The GNB@SiO2 with excellent photostability was used PA imaging well PTT. loaded ICG promised FL feasibility cancer theranostic...
Combined therapy provides a more effective method in the treatment of tumors and becomes research hotspot. To improve outcomes reduce serious side effects, hydrogel-based local delivery was developed herein to form drug depot suit eliminate tumors. Indocyanine green imiquimod were coencapsulated novel temperature-sensitive chitosan hydrogel. After intratumoral injection hydrogel, indocyanine that accumulated tumor area could induce thermal ablation primary under laser irradiation. In...