A5030278968- Nanoplatforms for cancer theranostics
- Dermatological and Skeletal Disorders
- Genetic and rare skin diseases.
- Cardiac Ischemia and Reperfusion
- Healthcare and Venom Research
- Cancer and Skin Lesions
- Surface Modification and Superhydrophobicity
- Hormonal and reproductive studies
- interferon and immune responses
- Photodynamic Therapy Research Studies
- Dermatologic Treatments and Research
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
Wenzhou Medical University
2016-2024
First Affiliated Hospital of Wenzhou Medical University
2016-2024
Xiaomi (China)
1999
Cyclic dinucleotides (CDNs) are a promising class of immune agonists that trigger the stimulator interferon genes (STING) to activate both innate and acquired immunity. However, efficacy CDNs is limited by drug delivery barriers. Therefore, we developed combined immunotherapy strategy based on injectable reactive oxygen species (ROS)-responsive hydrogels, which sustainably release 5,6-dimethylxanthenone-4-acetic acid (DMXAA) as known STING agonist indocyanine green (ICG) utilizing high level...
Combined therapy provides a more effective method in the treatment of tumors and becomes research hotspot. To improve outcomes reduce serious side effects, hydrogel-based local delivery was developed herein to form drug depot suit eliminate tumors. Indocyanine green imiquimod were coencapsulated novel temperature-sensitive chitosan hydrogel. After intratumoral injection hydrogel, indocyanine that accumulated tumor area could induce thermal ablation primary under laser irradiation. In...
To explore the role of Nrf2/ARE pathway in skeletal muscle ischemia/reperfusion(I/R) injury preconditioning by dexmedetomidine(DEX).Twenty-eight SD rats were randomly divided into sham-operated(Sham group)、I/R group、I/R+ DEX(DEX group) and I/R+DEX +Atipamezole (Atip group). In Atip group, Atip(250 μg/kg) DEX(25 injected together after anesthesia; Sham I/R groups, homologous saline was also at same time; DEX coinjected. After 30 minutes, hind limb ischemia induced clamping common femoral...