A5002515242- Carbon and Quantum Dots Applications
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Advanced biosensing and bioanalysis techniques
- Photosynthetic Processes and Mechanisms
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Nanocluster Synthesis and Applications
- melanin and skin pigmentation
- Metalloenzymes and iron-sulfur proteins
- Agricultural Innovations and Practices
- Lipid metabolism and biosynthesis
- Plant nutrient uptake and metabolism
- ATP Synthase and ATPases Research
- Fish Biology and Ecology Studies
- Renal and related cancers
- Endometriosis Research and Treatment
- Biochemical Analysis and Sensing Techniques
- Ophthalmology and Visual Impairment Studies
- Ginger and Zingiberaceae research
- Berry genetics and cultivation research
- Transcranial Magnetic Stimulation Studies
- Natural Compounds in Disease Treatment
China Agricultural University
2018-2025
Shandong University of Traditional Chinese Medicine
2023
Xinjiang Agricultural University
2023
Peking University Shenzhen Hospital
2022-2023
Chinese Academy of Sciences
2018-2022
Changchun Institute of Applied Chemistry
2018-2022
Peking University
2021
People's Hospital of Cangzhou
2021
University of Science and Technology of China
2018-2019
The First People's Hospital of Changde
2015-2019
As an essential and universal hydrolase, alkaline phosphatase (ALP) has been identified as a crucial indicator of various diseases. Herein, we, for the first time, expanded application fluorescent polydopamine (F-PDA) nanoparticles to nanoquencher-based biosensing system, well discovered reversible quenching effect manganese dioxide (MnO2) nanosheets on fluorescence F-PDA intensively confirmed mechanism Förster resonance energy transfer by using transmission electron microscopy, UV-vis,...
Therapeutic interventions of hepatic ischemia-reperfusion injury to attenuate liver dysfunction or multiple organ failure following surgery and transplantation remain limited. Here we present an innovative strategy by integrating a platinum nanoantioxidant inducible nitric oxide synthase into the zeolitic imidazolate framework-8 based hybrid nanoreactor for effective prevention injury. We show that can scavenge excessive reactive oxygen species at site meanwhile generate subsequent synthesis...
Abstract The energy sensor AMP-activated protein kinase (AMPK) can activate autophagy when cellular production becomes compromised. However, the degree to which nutrient sensing impinges on autophagosome closure remains unknown. Here, we provide mechanism underlying a plant unique FREE1, upon autophagy-induced SnRK1α1-mediated phosphorylation, functions as linkage between ATG conjugation system and ESCRT machinery regulate deprivation. Using high-resolution microscopy, 3D-electron...
Gentamicin-induced nephrotoxicity is one of the most common causes acute kidney injury (AKI). The phenotypic alterations that contribute to include inflammatory response and oxidative stress. Curcumin has a wide range biological functions, especially as an antioxidant. This study was designed evaluate renoprotective effects curcumin treatment in gentamicin-induced AKI.Gentamicin-induced AKI established female Sprague-Dawley rats. Rats were treated with (100 mg/kg body mass) by intragastric...
Alkaline phosphatase (ALP) usually acts as a signal transmitter in enzyme-linked immunosorbent assay (ELISA); therefore, developing an attractive ALP activity assay, especially using preferable substrate, would help improve the efficiency and convenience of ELISA practical applications. Herein we have first prepared original creative named m-hydroxyphenyl phosphate sodium salt (m-HPP), with desirable dephosphorylation site for ALP. On basis ALP-catalyzed hydrolysis m-HPP to resorcinol its...
Inspired by the coreactive activity of carbon nanodots (CDs) and branched polyethylenimine (BPEI) toward electrochemiluminescence (ECL) Ru(bpy)32+, a highly luminescent self-enhanced ECL nanohybrid (Ru-BCDs) was synthesized through covalently linking BPEI-coated dots (BCDs) with Tris (4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+). The composition morphological characterization demonstrated that spherical Ru-BCDs particles 12.1 ± 1.4 nm diameter were obtained....
Abstract High soil salinity negatively affects plant growth and development, leading to a severe decrease in crop production worldwide. Here, we report that secreted peptide, PAMP-INDUCED SECRETED PEPTIDE 3 (PIP3), plays an essential role salt tolerance through RECEPTOR-LIKE KINASE 7 (RLK7) Arabidopsis (Arabidopsis thaliana). The gene encoding the PIP3 precursor, prePIP3, was significantly induced by stress. Plants overexpressing prePIP3 exhibited enhanced tolerance, whereas knockout mutant...
The past few decades have witnessed explosive development in drug delivery systems. However, vivo suffers from non-specific distribution non-targeted organs or tissues, which may cause undesired side effects and even genotoxicity. Here, a general strategy that enables tuning the tropism of polymersomes for liver- spleen-selective is reported. By using library screening approach, spleen-targeted polymersome PH9-Aln-8020 liver-targeted PA9-ZP3-5050 are identified accordingly. Meanwhile, second...
Being a typical copper-containing oxidase, tyrosinase plays critical roles in biological activity, and its aberrant expression might cause diverse skin diseases. Herein, we, for the first time, have found an interesting green fluorogenic reaction between methyldopa ethanolamine. By combining transmission electron microscopy, UV–vis absorption spectroscopy, Fourier transform infrared X-ray photoelectron MALDI-TOF mass spectrum analysis, we confirmed that there is reliable method preparing...
IgA nephropathy (IgAN) is the finding of immune deposits predominantly containing polymeric in glomerular mesangium on renal biopsy. Recently studies show that inflammation may involve progression glomerulosclerosis and tubulointerstitial scarring IgAN. This study was designed to evaluate renoprotective effect triptolide IgAN rat model. induced Sprague–Dawley rats by oral intravenous immunization with BSA for 12 weeks. Rats were treated (200 μg/kg/d intragastrically) from 28 At Week 28,...
<b><i>Background/Aim:</i></b> Focal segmental glomerulosclerosis (FSGS) is a specific pattern of chronic renal injury with progressive glomerular scarring. The phenotypic alterations that contribute to FSGS include inflammatory response and oxidative stress. Astaxanthin (ATX) has broad range biological functions, particularly antioxidant anti-inflammatory ones. This study was designed evaluate the renoprotective effect ATX treatment on Adriamycin-induced FSGS....
Analyte-responsive chromo-fluorogenic reactions under accessible conditions are important for designing small-molecule spectroscopic probes. We describe a series of newly constructed motifs based on the reaction between catechol derivatives (typically hydroxytyrosol, dopamine, and levodopa) naphthoresorcin (NR) in aqueous solution ambient conditions. The weakly absorptive fluorogenic catechols/NR was converted to products having visible absorption bright fluorescence within several minutes....
Transforming growth factor β 1 (TGFβ1) plays a critical role in the epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells (TECs) during injury, major cause acute failure, fibrosis and obstructive nephropathy. However, underlying molecular mechanisms remain ill-defined. Here, we addressed this question.Expression TGFβ1, Snail, phosphorylated Stat3 was examined by immunohistochemistry kidney after induction unilateral ureteral obstruction (UUO) mice. In vitro, primary...
Comparing the priority order of different agricultural science and technology services adopted by cotton farmers exploring influencing factors service adoption from perspective farmer differentiation is significantly influential for high-quality development. We explore a based on 335 research data in Xinjiang China. The results show that following order: pest control technology, good seed precision sowing technology. Farm household fragmentation affects farm households. Gender satisfaction...
Abstract Salt stress causes ion toxicity in plant cells and limits growth crop productivity. Sodium ions (Na+) are transported out of the cell sequestered vacuole for detoxification under salt stress. The excretion system is controlled by SALT OVERLY SENSITIVE (SOS) pathway, which consists calcium sensors SOS3 SOS3-LIKE CALCIUM BINDING PROTEIN 8, protein kinase SOS2, plasma membrane Na+/H+ antiporter SOS1. Although much known about responses plants at molecular level, it remains unclear if...
Background: NSTEMI patients will benefit greatly with better biomarker screening to detect and prognose the disease. Using miRNAs, we evaluated clinical utility in acute myocardial infarction (AMI) during disease onset therapy. Methods: A total of 145 30 healthy volunteers no history cardiovascular (CVD) were recruited. miRNA levels plasma measured manifestation serially treatment phase. Levels multiple candidates (miR-1, miR-133, miR-208, miR-499) analysed. The directly compared between...
Lipid droplets (LDs), a dynamic organelle, are of vital importance in regulating the storage neutral lipids and energy homeostasis. The aberrant expression LDs is found to be highly associated with diverse metabolic diseases. Thus, detecting monitoring essential study pathological physiological processes living bodies. However, it remains challenging obtain suitable imaging probes track vivo. Fortunately, emergence carbon dots (CDs), which fluorescent nanomaterials good biocompatibility high...