A5100393558- Fatty Acid Research and Health
- Reproductive biology and impacts on aquatic species
- Gut microbiota and health
- Reproductive Biology and Fertility
- Echinoderm biology and ecology
- Cholesterol and Lipid Metabolism
- Sperm and Testicular Function
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Seaweed-derived Bioactive Compounds
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipid metabolism and biosynthesis
- COVID-19 epidemiological studies
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Birth, Development, and Health
Wuhan University
2018-2025
Hunan Academy of Traditional Chinese Medicine
2024-2025
Ocean University of China
2017-2025
Nankai University
2023-2025
Jinan University
2016-2025
Zhejiang University
2022-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Air Force Medical University
2023-2025
Xijing Hospital
2023-2025
Xi’an Jiaotong-Liverpool University
2025
Abstract Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting deubiquitinase, USP8, significantly enhances efficacy of anti-PD-1/PD-L1 through reshaping an inflamed tumor microenvironment (TME). Mechanistically, USP8 inhibition increases PD-L1...
Background: Curcumin, the active ingredient in curcuma rhizomes, has a wide range of therapeutic effects. However, its atheroprotective activity human acute monocytic leukemia THP-1 cells remains unclear. We investigated and molecular mechanism action curcumin polarized macrophages. Methods: Phorbol myristate acetate (PMA)-treated were differentiated to macrophages, which further M1 by lipopolysaccharide (LPS; 1 µg/ml) interferon (IFN)-γ (20 ng/ml) treated with varying concentrations....
Abstract Enantiopure vicinal amino alcohols and derivatives are essential structural motifs in natural products pharmaceutically active molecules, serve as main chiral sources asymmetric synthesis. Currently known catalytic protocols for this class of compounds still rare often suffer from limited scope substrates, relatively low regio- or stereoselectivities, thus prompting the development more effective methodologies. Herein we report a dual strategy convergent enantioselective synthesis...
A direct difunctionalization protocol of alkenes with nitriles and thiols toward β-acetamido sulfide derivatives has been proposed under metal-free synthesis conditions. The present provides the facile highly efficient various sulfides in a scaled-up manner good to excellent yields simply using inexpensive molecular iodine as catalyst, DMSO mild oxidant, readily available thiolating reagents.
Diabetic retinopathy (DR) has become a leading cause of global blindness as microvascular complication diabetes. Regular screening diabetic is strongly recommended for people with diabetes so that timely treatment can be provided to reduce the incidence visual impairment. However, DR not well carried out due lack eye care facilities, especially in rural areas China. Artificial intelligence (AI) based emerged novel strategy and show promising diagnostic performance sensitivity specificity,...
A massive rock and ice avalanche occurred on the western slope of Ronti Gad valley in northern part Chamoli, Indian Himalaya, 7 February 7, 2021. The high mountain at an elevation 5600 m above sea level triggered a long runout disaster chain, including mass avalanche, debris flood. chain had horizontal travel distance larger than 17,600 difference 4300 m. In this study, characteristics dynamic process were analyzed by multitemporal satellite imagery. results show that was caused four large...
The common and frequent disease, ulcerative colitis (UC), causes serious physical mental distress to patients. M2 macrophages have proven play a role in anti-inflammation, which is new potential target for UC therapy. In this study, we designed safe macrophages-targeting oral drug delivery system. Natural products, berberine (BBR), Epigallocatechin Gallate (EGCG) with anti-inflammatory activity were assembled encapsulated into yeast microcapsule (YM), generating therapeutic system...
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells, immune stromal cytokines, and chemokines which together govern progression response to immunotherapies. Methyltransferase-like 3 (METTL3), core catalytic subunit for RNA N6-methyladenosine (m6A) modification, plays crucial role in regulating various physiological pathological processes. Whether how METTL3 regulates the TME anti-tumor immunity non-small-cell lung (NSCLC) remain poorly understood. Here, we...
Abstract Faced with challenging cases, doctors are increasingly seeking diagnostic advice from large language models (LLMs). This study aims to compare the ability of LLMs and human physicians diagnose cases. An offline dataset 67 cases primary gastrointestinal symptoms was used solicit possible diagnoses seven 22 gastroenterologists. The by Claude 3.5 Sonnet covered highest proportion (95% confidence interval [CI]) instructive (76.1%, [70.6%–80.9%]), significantly surpassing all...
AimsEndothelial progenitor cells (EPCs) are capable of proliferating and differentiating into mature endothelial cells, they have been considered as potential candidates for coronary heart disease therapy. However, the transition EPCs to mesenchymal is not fully understood. This study aimed explore role microRNA 126 (miR-126) in endothelial-to-mesenchymal (EndMT) induced by transforming growth factor beta 1 (TGFβ1). Methods ResultsEndMT rat bone marrow-derived was TGFβ1 (5 ng/mL) 7 days....
Regulation of mitochondrial biogenesis and respiration is a complex process that involves several signaling pathways transcription factors as well communication between the nuclear genomes. Under aerobic conditions, budding yeast Saccharomyces cerevisiae metabolizes glucose predominantly by glycolysis fermentation. We have recently shown altered chromatin structure in induces mechanism requires transport metabolism pyruvate mitochondria. However, how controls transcriptional responses...
The possible molecular mechanism of EPA-pPE and EPA-PE on AD.
Metabolic stress induced by a high-fat (HF) diet leads to cognitive dysfunction and aging. In the present study, Chinese hamster ovary cells stably transfected with amyloid precursor protein (APP) presenilin 1 (PS1) (CHO-APP/PS1 cells) SAMP8 mice fed an HF were used study effects of docosahexaenoic acid (DHA)-enriched phosphatidylcholine (DHA-PC) eicosapentaenoic (EPA)-enriched (EPA-PC) on Alzheimer's disease (AD) possible mechanisms involved in these effects. Behavior test results indicated...