A5068985012- interferon and immune responses
- RNA modifications and cancer
- Immune Response and Inflammation
- Sulfur Compounds in Biology
- UAV Applications and Optimization
- Tryptophan and brain disorders
- Nuclear Physics and Applications
- Indoor and Outdoor Localization Technologies
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Radiation Detection and Scintillator Technologies
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Treatment of Major Depression
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Underwater Acoustics Research
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Medical Imaging Techniques and Applications
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Neurogenesis and neuroplasticity mechanisms
- T-cell and B-cell Immunology
- Video Surveillance and Tracking Methods
Beijing Normal University
2022-2023
Shandong University
2015-2023
Western University
2022
Jiangxi University of Science and Technology
2020-2021
To address the threat of drones intruding into high-security areas, real-time detection is urgently required to protect these areas. There are two main difficulties in drones. One them that move quickly, which leads requiring faster detectors. Another problem small difficult detect. In this paper, firstly, we achieve high accuracy by evaluating three state-of-the-art object methods: RetinaNet, FCOS, YOLOv3 and YOLOv4. Then, first problem, prune convolutional channel shortcut layer YOLOv4...
TBK1 is an essential kinase for the innate immune response against viral infection. However, key molecular mechanisms regulating activation remain elusive. Here, we identify PRMT1, a type I protein arginine methyltransferase, as regulator of activation. PRMT1 directly interacts with and catalyzes asymmetric methylation R54, R134, R228 on TBK1. This modification enhances oligomerization after infection, which subsequently promotes phosphorylation downstream interferon production. More...
Abstract Although the neuroprotective effects of hydrogen sulfide (H 2 S) have been demonstrated in several studies, whether H S protects against early brain injury (EBI) and secondary cognitive dysfunction subarachnoid hemorrhage (SAH) model remains unknown. This study was undertaken to evaluate influence on both acute neurobehavioral changes as well underlying mechanisms after SAH. The donor, NaHS, administered via an intraperitoneal injection at a dose 5.6 mg/kg h, 6 24 46 h SAH rat...
Abstract Spleen tyrosine kinase (SYK) is a non-receptor kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly understood. Here we identified E3 ligase TRIM31 as crucial regulator of activation. We found interacted with catalyzed K27-linked polyubiquitination at Lys375 Lys517 SYK. This promoted its plasma membrane translocation binding C-type lectin receptors (CLRs), also prevented interaction...
// Qun Zhang 1 , Song Liu Tong Li Lin Yuan Hansen 2 Xueer Wang Fuwu 3 Shuanglian Aijun Hao Dexiang Zhen 1, Department of Physiology, Shandong University School Medicine, Jinan, 250012, P.R. China Medical Psychology, Key Laboratory the Ministry Education for Experimental Teratology, Provincial Mental Disorders, Histology and Embryology, Correspondence to: Liu, email: Liudexiang@sdu.edu.cn Wang, wangzhen@sdu.edu.cn Keywords: hydrogen sulfide, bone marrow mesenchymal stem cells, transplants,...
Stringent regulation of the transcription factor NF-κB signaling is essential for activation host immune responses and maintaining homeostasis, yet molecular mechanisms involved in its tight are not completely understood. In this study, we report that IKK-interacting protein (IKIP) negatively regulates activation. IKIP interacted with IKKα/β to block association NEMO, thereby inhibiting phosphorylation NF-κB. Upon LPS, TNF-α, IL-1β stimulation, IKIP-deficient macrophages exhibited more...
ABSTRACT Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It chiefly regulated by Keap1, a substrate adaptor protein that mediates degradation. activity also influenced many other interactions provide Keap1-independent regulation. To study regulation, we established and characterized yeast models expressing human (also known as NFE2L2), Keap1 proteins interact with regulate Nrf2. Yeast have been well powerful tools to function genetic physical...
Unmanned Aerial Vehicles (UAVs), in recent years, are developing rapidly. However, when fly into private residences or public areas without authorizations, UAVs pose latent threats to personal privacy and security. localization is a significant part of an anti-UAV system. In this paper, remolded acoustic energy decay model preserved relative attenuation inverse distance square used generate training data. Multilayer perceptron(MLP) the train these data predicts accurate 3D space coordinates....
Abstract The IκB kinase (IKK) complex plays a vital role in regulating the NF-κB activation. Aberrant activation is involved various inflammatory diseases. Thus, targeting IKK an ideal therapeutic strategy to cure and prevent diseases related In previous study, we demonstrated that IKK-interacting protein (IKIP) inhibits phosphorylation of IKKα/β through disruption formation complex. this identified 15-aa peptide derived from mouse IKIP (46–60 aa IKIP), which specifically suppressed targeted...
Compton camera is an extremely important technology to observe the prompt emissions from gamma-ray bursts. To improve imaging efficiency of regions directly ahead system, a novel with annular absorber was proposed and evaluated. The sensitivity angular resolution such were compared those typical two planar detectors. scatterers cameras identical contained 8 × GAGG crystals, dimensions 10 5 mm3. in each measures Sixty-four also measuring mm3, arranged shape inner radius ~51.5 mm outer ~73.9...
Unmanned aerial vehicles (UAVs) have developed rapidly and are widely used in many fields. This phenomenon also causes security problems that urgently need to be addressed by anti-UAV technique. The localization of UAV plays an important role system. An acoustic source scheme based on machine learning (ML) wireless sensor networks is proposed this study. Five ML algorithms, namely, artificial neural network (ANN), Naive Bayes, decision tree (DT), K nearest neighbors (KNN) random forest (RF),...
Upon viral infection, several proteins in the innate signaling pathway form aggregates, which turn promote activation of antiviral immune response. In this protocol, we use herpes simplex virus type 1 (HSV-1) to infect mouse peritoneal macrophages, and show how detect aggregation TBK1 upon infection. The protocol is adaptable for other viruses. For complete details on execution profile, please refer Yan et al. (2021).
This paper proposed a novel Compton camera with an annular absorber which improved the imaging efficiency of immediate regions. We compared sensitivity and angular resolution such those typical two planar detectors. The scatterers consisted 8×8 GAGG crystals, each measuring 1 cm×1 cm×0.5 cm same system was composed measures cm. as one, but sixty-four also cm, were arranged in shape inner radius ~5.15 outer ~7.39 A point <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...