A5100393465- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Circular RNAs in diseases
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Glycosylation and Glycoproteins Research
- Advanced MRI Techniques and Applications
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Monoclonal and Polyclonal Antibodies Research
- Insect Resistance and Genetics
The First People's Hospital of Changzhou
2024
National University Heart Centre Singapore
2016-2024
National University of Singapore
2013-2023
University of South China
2023
National University Health System
2014-2023
Beijing University of Chinese Medicine
2023
Wuhan University
2017-2022
West China Medical Center of Sichuan University
2022
Zhejiang Chinese Medical University
2021
South China University of Technology
2020
It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's disease (AD) brains are higher than healthy brains, but direct evidence from living beings is scarce. Herein, we report a NIR emissive fluorescent probe with large Stokes shift for associated detection of mitochondrial live rat AD first time.
Increased levels of O-linked attachment N-acetylglucosamine ( O-GlcNAc) on nucleocytoplasmic proteins are implicated in the development diabetic cardiomyopathy and regulated by O-GlcNAc transferase (OGT) expression its substrate UDP-GlcNAc. Therefore, goal this study was to determine whether diabetes Zucker fatty (ZDF) rat, a model Type 2 diabetes, results defects cardiomyocyte mechanical function and, if so, is associated with increased OGT expression. Six-week-old ZDF rats were...
Asthma is a chronic inflammatory disease, with hyper-responsive bronchoconstriction and airway remodelling, leading to extensive narrowing. The regulation of responsiveness inflammation by endogenous hydrogen sulfide (H(2)S) during the pathogenic development asthma has been suggested. Hydrogen can be produced in lung tissues via actions two H(2)S-generating enzymes, cystathionine β-synthase (CBS) and/or γ-lyase (CSE). abnormal metabolism function H(2)S have reported experimental animals...
In vivo, cells migrate on complex three-dimensional (3D) fibrous matrices, which has made investigation of the key molecular and physical mechanisms that drive cell migration difficult. Using reductionist approaches based 3D electrospun fibers, we report for various types single-cell along fibronectin-coated nanofibers is associated with lateral actin-based waves. These cyclical waves have a fin-like shape propagate up to several hundred micrometers from body, extending leading edge...
The goal of this study was to determine whether changes in cardiac metabolism Type 2 diabetes are associated with contractile dysfunction or impaired response ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats were isolated perfused glucose, lactate, pyruvate, palmitate. rates palmitate oxidation glycolysis determined during baseline perfusion low-flow ischemia (LFI; 0.3 ml/min for 30 min) after LFI reperfusion. Under all conditions, ATP synthesis increased lactate...
Heart failure is a leading cause of mortality and morbidity, the search for novel therapeutic approaches continues. In monogenic disease mucopolysaccharidosis VI, loss-of-function mutations in arylsulfatase B lead to myocardial accumulation chondroitin sulfate (CS) glycosaminoglycans, manifesting as myriad cardiac symptoms. Here, we studied changes CS nonmucopolysaccharidosis failing hearts assessed its generic role pathological remodeling. Healthy diseased human rat left ventricles were...
Reduced myocardial miR-221 expression is associated with severe cardiac fibrosis in heart failure patients. We aimed to demonstrate its mechanisms cardioprotection and remodeling following infarction (MI). Using vitro hypoxia reoxygenation (H/R) of H9c2 rat fibroblast (cFB) models, we found that protects through combined anti-apoptotic anti-autophagic effects cFB via alone H/R. It inhibits myofibroblast (myoFB) activation as indicated by lowering α-smooth muscle actin (α-SMA) expression, gel...
The aim of this study was to determine whether the transition from insulin resistance hyperglycemia in a model type 2 diabetes leads intrinsic changes myocardium that increase sensitivity ischemic injury. Hearts 6-, 12-, and 24-wk-old lean (Control) obese Zucker diabetic fatty (ZDF) rats were isolated, perfused, subjected 30 min low-flow ischemia (LFI) 60 reperfusion. At 6 wk, ZDF animals resistant but not hyperglycemic. By 12 group hyperglycemic became progressively worse by 24 wk. In...
Inhibition of fatty acid oxidation has been reported to be cardioprotective against myocardial ischemic injury; however, recent studies have questioned whether the cardioprotection associated with putative inhibitors, such as ranolazine and trimetazidine, are due changes in substrate oxidation. Therefore, goals this study were compare effects a new inhibitor, CVT-4325...
A highly efficient approach to select microRNA (miRNA) targets is a key develop miRNA-based therapeutic cardiac ischemia-reperfusion (I/R). To reverse the change induced by disease, I/R in this case, traditional strategy drugs. However, examples show that it will not always serve purpose. In study, we demonstrate an additional of selecting miRNA with potential following cues from cardioprotection-induced changes rather than reversing disease-induced I/R.Isolated perfused rat hearts subjected...