A5027156402- interferon and immune responses
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Hematopoietic Stem Cell Transplantation
- Inflammasome and immune disorders
- RNA regulation and disease
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Supramolecular Self-Assembly in Materials
- Biochemical and Structural Characterization
- IoT-based Smart Home Systems
- Whipple's Disease and Interleukins
- Genetic factors in colorectal cancer
- Retinoids in leukemia and cellular processes
- Carcinogens and Genotoxicity Assessment
- Advanced biosensing and bioanalysis techniques
- Bacterial biofilms and quorum sensing
Chinese Academy of Sciences
2014-2024
University of Chinese Academy of Sciences
2017-2024
Institute of Hydrobiology
2024
Wuhan Institute of Virology
2014-2020
Jinyintan Hospital
2020
Hangzhou Dianzi University
2015-2020
ShanghaiTech University
2017-2018
Center for Excellence in Brain Science and Intelligence Technology
2018
Guizhou University
2008-2011
Sichuan University
2008
Abstract Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies shown that some bat SARSr-CoVs potential to infect humans 5–7 Here we report identification and characterization new coronavirus (2019-nCoV), which caused an epidemic Wuhan, China. The epidemic, started on 12 December 2019, had 2,794 laboratory-confirmed infections...
Interleukin (IL)-16, a multifunctional cytokine, plays fundamental role in inflammatory diseases, as well the development and progression of tumors. Genetic variation DNA sequence IL-16 gene may lead to altered cytokine production and/or activity, this modulate an individual's susceptibility both colorectal cancer (CRC) gastric (GC). To test hypothesis, we investigated association polymorphisms with serum levels risk CRC GC Chinese population. We analyzed single-nucleotide 596 patients (376...
Toll‐like receptor 3 (TLR3) recognizes dsRNA generated during viral infection and activation of TLR3 results in induction type I interferons (IFNs) cellular anti‐viral response. is associated with a TIR domain‐containing adapter protein TRIF, which activates distinct downstream pathways leading to NF‐κB ISRE sites the promoters IFNs. We show here that A20, NF‐κB‐inducible zinc finger has been demonstrated be an inhibitor TNF‐induced physiological suppressor inflammatory response, potently...
Abstract Mediator of IFN regulatory transcription factor 3 activation (MITA) is an important adaptor protein to mediate the induction type I IFNs. In this study, we identified alternatively spliced isoform MITA lacking exon 7, termed MITA-related (MRP). MRP shares N-terminal portion aa 1–253 with but possesses a unique 30-aa sequence at carboxyl terminal part, therefore conserved domains including TANK-binding kinase 1 (TBK1) and cyclic diguanylate binding domain. expressed in multiple...
Self-assembling supramolecular nanofibers, common in the natural world, are of fundamental interest and technical importance to both nanotechnology materials science. Despite important advances, synthetic nanofibers still lack structural functional diversity biological molecules, controlled assembly one type molecule into a variety fibrous structures with wide-ranging attributes remains challenging. Here, we harness low-complexity (LC) sequence domain fused sarcoma (FUS) protein, an...
Abstract Class II HDACs, such as HDAC4, are critical regulators of the immune response in various cells; however, its role innate immunity remains largely unknown. Here, we report that overexpression HDAC4 suppresses production type I interferons triggered by pattern-recognition receptors (PRRs). repressed translocation transcription factor IRF3 to nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, also determined can be phosphorylated and simultaneously block...
Abstract Protein modification by small ubiquitin-like modifier (SUMO) is an important regulatory mechanism for multiple cellular processes. Although the canonical pathway involving ubiquitylation or phosphorylation of IκBα has been well characterized, little known about sumoylation in control NF-κB activity. Here, we find that histone deacetylase 4 (HDAC4) negatively regulates tumor necrosis factor-alpha- lipopolysaccharide-triggered activation. HDAC4 belongs to SUMO E3 ligase family and can...
An efficient clearance of hepatitis B virus (HBV) requires the coordinated work both innate and adaptive immune responses. MITA/STING, an adapter protein signaling pathways, plays a key role in regulating responses to DNA infection. Previously, we identified alternatively spliced isoform called MITA-related (MRP), found that MRP could specifically block MITA-mediated interferon (IFN) induction while retaining ability activate NF-κB. Here, asked whether MITA/STING were able control HBV...
WD repeat-containing protein 5 (WDR5) is essential for assembling the VISA-associated complex to induce a type I interferon antiviral response Sendai virus infection. However, roles of WDR5 in DNA infections are not well described. Here, we report that human cytomegalovirus exploits facilitate capsid nuclear egress. Overexpression fibroblasts slightly enhanced infectious yield. knockdown dramatically reduced titers with only small decrease viral genome replication or gene expression. Further...
As a key molecule in the antiviral innate immune response, activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as host factor that modulates TBK1 activation. Knockdown expression suppressed signaling induced by RNA viruses, while overexpression enhanced signaling. functioned at level pathway, silencing blocked TBK1, but not interferon regulatory 3 (IRF3) interferon-β (IFN-β) promoter activity. The...
Upon virus infection, retinoic acid-inducible gene I-like receptors in host cells recognize viral RNA and activate type I IFN expression. Previously, we identified WD repeat domain (WDR) 5 as one positive regulator for pathway activation. In this study, report that WDR82, a homolog protein of WDR5, acts opposite to WDR5 inhibits the activation signaling pathway. WDR82 overexpression virus-triggered activation, whereas its knockdown enhances induced IFN-β is localized on mitochondria, first...
IFN regulatory factor 3 (IRF3) is the transcription crucial for production of type I in viral defence and inflammatory responses. The activity IRF3 strictly modulated by post-translational modifications (PTMs) to effectively protect host from infection while avoiding excessive immunopathology. Here, we report that zebrafish myosin-regulated light chain interacting protein b ( mylipb ) inhibits virus-induced via two synergistic mechanisms: induction autophagic degradation irf3 reduction...
Cyclin-dependent kinase inhibitors (CKIs) p18INK4c (p18) and p27Kip1 (p27) were reported to be able modulate self-renewal differentiation of hematopoietic stem cells (HSCs) progenitor cells, regulate the lineage cell proliferation maturation into terminal elements; however, whether p18 p27 in HSCs affect development especially B lymphocytes, reconstituted blood is unknown. Here we employed small-interference RNA (siRNA) technique, which provides a powerful tool for tissue-targeted knockdown...
A combination of extrinsic hematopoietic growth regulators, such as stem cell factor (SCF), interleukin (IL)-3 and IL-6, can induce division quiescent cells (HSCs), but it usually impairs HSCs' self-renewal ability. However, intrinsic negative cycle p18INK4C (p18), p27Kip1 (p27) MAD1, regulate the HSCs. It is unknown whether removal some regulators knockdown via RNA interference (RNAi) ex vivo expansion To address this question, a lentiviral vector-based RNAi tool was developed to produce...