A5044676710- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Hypothalamic control of reproductive hormones
- Reproductive Biology and Fertility
- Genomics and Phylogenetic Studies
- Cancer Mechanisms and Therapy
- Endometriosis Research and Treatment
- Plant-Microbe Interactions and Immunity
- Nuts composition and effects
- RNA modifications and cancer
- Plant and Fungal Interactions Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Food composition and properties
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Peroxisome Proliferator-Activated Receptors
- Microbial Natural Products and Biosynthesis
- Graphene and Nanomaterials Applications
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
University of Science and Technology of China
2025
Fujian Medical University
2016-2024
Jinshan Hospital of Fudan University
2023-2024
Codexis (United States)
2024
Qingdao Agricultural University
2022-2024
Dalian Polytechnic University
2022-2024
Shenyang Pharmaceutical University
2017-2023
HBIS (China)
2023
Nanjing Agricultural University
2018-2022
Nantong University
2020-2022
Abstract Nesfatin-1 is an important molecule in the regulation of reproduction. However, its role reproductive axis male animals remains to be understood. Here, we found that nesfatin-1 was mainly distributed arcuate nucleus (ARC), paraventricular (PVN), periventricular (PeN), and lateral hypothalamic area (LHA) hypothalamus; adenohypophysis Leydig cells rats. Moreover, concentrations serum mRNA hypothalamo-pituitary-gonadal (HPGA) vary with age rat. After intracerebroventricular injection...
Long non-coding RNAs (lncRNAs) regulate the development of follicles and reproductive diseases, but mechanisms by which lncRNAs ovarian functions fertility remain elusive. We profiled expression in tissues Hu sheep with different prolificacy identified 21,327 lncRNAs. Many were differentially expressed groups. further characterized an lncRNA that was predominantly ovaries low FecB+ (LPB+) group mainly present granulosa cells (GCs), this decreased during follicular development, we named...
Long noncoding RNAs (lncRNAs) are involved in regulating animal development, however, their function the onset of puberty goats remain largely unexplored. To identify genes controlling regulation goats, we measured lncRNA and mRNA expression levels from hypothalamus. We applied RNA sequencing analysis to examine hypothalamus pubertal (case; n = 3) prepubertal (control; goats. Our results showed 2943 predicted lncRNAs, including 2012 differentially expressed which corresponded 5412 target...
Female pubertal development is tightly controlled by complex mechanisms, including neuroendocrine and epigenetic regulatory pathways. Specific gene expression patterns can be influenced DNA methylation changes in the hypothalamus, which turn regulate timing of puberty onset. In order to understand relationship between hypothalamus goats, whole-genome bisulfite sequencing RNA-sequencing analyses were carried out. There was a decline levels during 268 differentially methylated regions (DMR)...
Abstract Class II HDACs, such as HDAC4, are critical regulators of the immune response in various cells; however, its role innate immunity remains largely unknown. Here, we report that overexpression HDAC4 suppresses production type I interferons triggered by pattern-recognition receptors (PRRs). repressed translocation transcription factor IRF3 to nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, also determined can be phosphorylated and simultaneously block...
Circular RNAs (circRNAs) are an indispensable element of post-transcriptional gene regulation, influencing a variety biological processes including myogenic differentiation; however, little is known about the function circRNA in goat differentiation. Using RNA-sequencing data from our laboratory, we explored influences circUSP13, as candidate circRNA, on myoblast differentiation since its expression higher myoblasts lamb (first day age) than that fetus (75th pregnancy). In vitro experiments,...
Over the past a few years, evidences indicate that adenosine triphosphate (ATP) is an energy source for binding, maturation, assembly, and budding process of many enveloped viruses. Our previous studies suggest F1-ATP synthase beta subunit (ATPsyn β, BP53) shrimp Litopenaeus vannamei (L. vannamei) might serve as potential receptor white spot syndrome virus (WSSV)’s infection. BP53 was localized on surface hemocytes gill epithelial cells by immunofluorescence assay immunogold labeling...
Porcine reproductive and respiratory syndrome (PRRS) caused by a single-stranded RNA virus, PRRSV, is highly infectious disease leads to huge economic losses the swine industry worldwide. To investigate role of miRNAs in infection lung injury induced differentially expressed (DE-miRs) were isolated from PRRSV infected/mock-infected PAMs Meishan, Landrace, Pietrain Qingping pigs at 9hpi, 36hpi, 60hpi. Mir-331-3p was only common DE-miR 4 pig breeds 36hpi one DE-miRs Landrace Mir-210 7...
Runt-related transcription factor 1 translocation partner (RUNX1T1), a potential novel regulator of adipogenesis, exists in two splice variants: long (RUNX1T1-L) and short (RUNX1T1-S) isoform. However, there is no data showing the existence RUNX1T1 ovine subcutaneous fat at different stages developmental its role on adipogenesis. Therefore, objectives this study were to evaluate presence five-day-old 24-month-old sheep investigate In study, we detected 1829 bp cDNA fragment which contains...
Puberty is a pivotal stage in female animal development, and marks the onset of reproductive capability. However, little known about function lncRNAs (long noncoding RNAs) puberty. Therefore, RNA-seq analysis were performed between goats rats to clarify roles mRNAs In present study, length lncRNAs, open reading frame exon count compared two species. Furthermore, functional annotation based on Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) target genes differentially expressed...
In March 2020, widespread anthracnose was observed on soybean (Glycine max) in southeastern Jiangsu (Nantong municipality; 120.53° E, 31.58° N) China. Plants exhibited irregular brown necrotic lesions stem and leaves, pronounced wilting. The symptoms were detected one field, 0.42 ha, surrounded by healthy wheat fields. Approximately 65% of the plants showed disease symptoms, crop yield reduced 28-35% with respect achieved previous years, when no observed. consistent those previously reported...
There are many variables affecting the onset of puberty in animals, including genetic, nutritional, and environmental factors. Recent studies suggest that epigenetic regulation, especially DNA methylation, plays a majorrole regulation puberty. However, there have been no reports on methylation pubertal genome. We investigated female rat hypothalamus at prepuberty using reduced representation bisulfite sequencing technology. The identified genes signaling pathways exhibiting changes to rats...
As a key molecule in the antiviral innate immune response, activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as host factor that modulates TBK1 activation. Knockdown expression suppressed signaling induced by RNA viruses, while overexpression enhanced signaling. functioned at level pathway, silencing blocked TBK1, but not interferon regulatory 3 (IRF3) interferon-β (IFN-β) promoter activity. The...