A5113616202- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Lipid metabolism and biosynthesis
- Pluripotent Stem Cells Research
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Human Pose and Action Recognition
- Lipoproteins and Cardiovascular Health
- Reproductive Physiology in Livestock
- Sperm and Testicular Function
- Fault Detection and Control Systems
- Autophagy in Disease and Therapy
- FOXO transcription factor regulation
- Renal and related cancers
- Multimodal Machine Learning Applications
Nanjing Agricultural University
2016-2025
Chinese Academy of Sciences
2023-2024
Jilin University
2023-2024
Wuhan Engineering Science & Technology Institute
2023-2024
University of Science and Technology of China
2023-2024
Shenzhen Institutes of Advanced Technology
2023-2024
Suzhou University of Science and Technology
2024
Xinjiang University
2023-2024
Tsinghua University
2023
Shanghai University of Engineering Science
2021-2023
Pyroptosis is a new programmed cell death discovered in recent years. plays an important role various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using help understand future development basic clinical research.The articles reviews regarding were culled from Web Science Core Collection. Countries, institutions, authors, references keywords field visually analyzed by...
To identify the cooperation and impact of authors, countries, institutions, journals, evaluate knowledge base, find hotspot trends, detect emerging topics regarding ferroptosis research.The articles reviews related to were obtained from Web Science Core Collection on November 1, 2020. Two scientometric software (CiteSpace 5.7 VOSviewer 1.6.15) used perform bibliometric knowledge-map analysis.A total 1,267 papers included, in 466 academic journals by 6,867 authors 438 institutions 61...
Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies this field. We aimed to visualize the hotspots trends of exosomes CVDs using a analysis help understand future development basic clinical research. Methods: The articles reviews regarding were culled from Web Science Core Collection, knowledge maps generated CiteSpace VOSviewer software. Results: A total 1,039...
Abstract Background DNA methylation is an epigenetic regulatory form that plays important role in regulating the gene expression and tissues development.. However, regulators involved sheep muscle development remain unclear. To explore functional importance of genome-scale during growth, this study systematically investigated genome-wide profiles at key stages Hu developmental (fetus adult) using deep whole-genome bisulfite sequencing (WGBS). Results Our found levels methyltransferase...
N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the of m6A skeletal muscle development remains largely unknown. Here, we report global pattern goat at two key stages and identified that regulated expression growth arrest DNA damage-inducible 45B (GADD45B) gene, which is involved myogenic differentiation. We showed GADD45B increased during myoblast differentiation, whereas downregulation inhibits differentiation mitochondrial biogenesis....
Excessive fat deposition is the main character in nonalcoholic fatty liver disease (NAFLD), while γ-linolenic acid (GLA) a polyunsaturated that can reduce lipid deposition. This study investigated effect and regulatory mechanism of GLA (100 μM) on metabolism alpha mouse 12 (AML-12) cells treated by 400 μM palmitic (PA). reduced content increased β oxidation, as indicated decreasing triglyceride cholesterol contents increasing mRNA protein expressions CPT1α PPARα. relieved oxidative stress...
Understanding the genetic characteristics of indigenous goat breeds is vital for their conservation and breeding. Haimen goats, native to China’s Yangtze River Delta, possess distinctive traits such as white hair, moderate growth rate, high-quality meat, small body size. However, knowledge regarding structure germplasm goats remains limited. In this study, we performed 20× whole-genome resequencing 90 (60 30 Boer goats) identify single-nucleotide polymorphisms (SNPs) insertions/deletions...
Aim A comprehensive safety assessment of potential probiotic strains was essential for their application in the food industry. This article systematically evaluated characteristics, whole-genome sequence analysis and Lacticaseibacillus paracasei LC86 casei LC89. Methods Firstly, two lactic acid bacteria selected were identified. Secondly, sequencing performed on LC89, antibiotic resistance, pathogenicity, virulence genes analyzed. We tested various properties strains, included tolerance,...
As an important type of noncoding RNA molecules, long non-coding RNAs (lncRNAs) act as versatile players in various biological processes. However, little is known about lncRNA regulators during sheep muscle growth. To explore functional lncRNAs growth, we systematically investigated using strand-specific Ribo-Zero sequencing at three key developmental stages Hu sheep. A total 6924 were obtained, and the differentially expressed genes screened from (control vs. experiment) fetus lamb, lamb...
During goat follicular development, abnormal expression of nuclear respiratory factor 1 ( NRF1 ) in granulosa cells may drive atresia with unknown regulatory mechanisms. In this study, we investigated the effects on steroidogenesis and cell apoptosis by overexpressing or silencing it luteinized (LGCs). Results showed that knockdown significantly inhibited STAR CYP19A1 , which are involved sex steroid hormones synthesis, led to lower estrogen levels. Knockdown resulted an increased percentage...
Circular RNAs (circRNAs) are an indispensable element of post-transcriptional gene regulation, influencing a variety biological processes including myogenic differentiation; however, little is known about the function circRNA in goat differentiation. Using RNA-sequencing data from our laboratory, we explored influences circUSP13, as candidate circRNA, on myoblast differentiation since its expression higher myoblasts lamb (first day age) than that fetus (75th pregnancy). In vitro experiments,...