A5100411866- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Plant-Microbe Interactions and Immunity
- Cancer, Hypoxia, and Metabolism
- Respiratory viral infections research
- Genomics and Chromatin Dynamics
- Influenza Virus Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- RNA and protein synthesis mechanisms
- Plant biochemistry and biosynthesis
- Gut microbiota and health
- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Microbial Natural Products and Biosynthesis
- Adipose Tissue and Metabolism
- Virology and Viral Diseases
- Genetic factors in colorectal cancer
- Gestational Diabetes Research and Management
University of California, Los Angeles
2020-2025
Shandong Agricultural University
2018-2025
Ministry of Agriculture and Rural Affairs
2025
University of California, San Francisco
2003-2024
Cotton Research Institute
2024
Chinese Academy of Agricultural Sciences
2020-2024
Zhengzhou University
2024
University of Kentucky
2021-2024
Xinjiang Agricultural University
2019-2024
Tianjin Medical University General Hospital
2024
Abstract Background As core units of organ tissues, cells various types play their harmonious rhythms to maintain the homeostasis human body. It is essential identify characteristics in organs and regulatory networks for understanding biological mechanisms related health disease. However, a systematic comprehensive single-cell transcriptional profile across multiple normal adult missing. Results We perform transcriptomes 84,363 derived from 15 tissue one donor generate an cell atlas. The...
Abstract Individual cells are basic units of life. Despite extensive efforts to characterize the cellular heterogeneity different organisms, cross-species comparisons landscape dynamics have not been achieved. Here, we applied single-cell RNA sequencing (scRNA-seq) map organism-level cell landscapes at multiple life stages for mice, zebrafish and Drosophila. By integrating comprehensive dataset > 2.6 million single cells, constructed a identified signatures common pathways that...
Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative torsional strain, which occurs during replication and transcription, may lead genomic instability. However, how ADS are recognized in cells is unclear. We found that the binding candidate anticancer drug, curaxin, cellular results uncoiling nucleosomal DNA, accumulation supercoiling conversion multiple regions into left-handed Z-form. Histone chaperone FACT binds rapidly same via SSRP1 subunit...
Rigid polyurethane foam (RPUF) is one of the most widely used construction materials, but it flammable and releases toxic smoke during combustion. In this study, a novel, synergistic-effect flame retardant (FPASO-DOPO) was synthesized by Atherton–Todd reaction 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) with fumaropimaric acid-based siloxane (FPASO). The obtained FPASO-DOPO then introduced into cross-linking network an RPUF chemical bonding. retardancy enhanced synergistic...
Abstract Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA nominating susceptibility genes. Here, we performed a 3′ untranslated region (3′UTR) TWAS (3′aTWAS) for 11 disorders by combining their genome-wide data with 17,300 RNA-seq samples across 2,937 individuals. We identified 354 3′aTWAS-significant genes, including known APA-linked risk such as SNCA Parkinson’s disease. Among...
All nonmammalian vertebrates studied can regenerate inner ear mechanosensory receptors (i.e., hair cells) (Corwin and Cotanche, 1988; Lombarte et al., 1993; Baird 1996), but mammals possess only a very limited capacity for regeneration after birth (Roberson Rubel, 1994). As result, experience permanent deficiencies in hearing balance once their cells are lost. The mechanisms of cell poorly understood. Because the sensory epithelium is highly conserved all (Fritzsch 2007), we chose to study...
Ovarian cancer has a poor prognosis, with different outcomes for patients. The mechanism underlying this prognosis and heterogeneity is not well understood. We have developed an unbiased, adaptive clustering approach to integratively analyze ovarian genome-wide gene expression, DNA methylation, microRNA copy number alteration profiles. uncovered seven previously uncategorized subtypes of that differ significantly in median survival time. then algorithm uncover molecular signatures...
Rationale: Tanshinone, a type of diterpenes derived from salvia miltiorrhiza, is particularly promising herbal medicine compound for the treatment cancers including acute myeloid leukemia (AML). However, therapeutic function and underlying mechanism Tanshinone in AML are not clear, toxic effect limits its clinical application. Methods: Our work utilizes human cell lines, zebrafish transgenics xenograft models to study cellular molecular mechanisms how affects normal abnormal hematopoiesis....
More than a decade of gut microbiome studies have common goal improving human health. However, while most the disease focused on elderly or middle-aged, reference cohort for in young individuals has been lacking. It is also not clear what other omics data need to be measured better understand microbiome. Here, we present including 2183 adults with high-depth metagenomic shotgun sequencing fecal and data. In this multiomic cohort, observe number vitamins, hormones, amino acids, trace elements...
Candida tropicalis (C. tropicalis) is an important opportunistic pathogenic species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C. relationship between ERG11 UPC2 expression resistance to azole antifungal agents.C. was cultured identified by Sabouraud Agar Medium, CHROM ATB tests (Bio-Mérieux, France). Total RNA extracted from collected strains, mRNA levels were quantitative real-time PCR.In total, 2872 clinical isolates...
Influenza D virus (IDV), with bovines as a primary host, circulates widely in cattle populations across North America and Eurasia. Here we report the identification of novel IDV group broad antigenicity U.S. bovine herds, which is genetically different from previously known lineages IDV.
Abstract Women show resilience to cognitive aging, in the absence of dementia, many populations. To dissect sex differences, we utilized FCG and XY * mouse models. Female gonads chromosomes improved cognition aging mice both sexes. Further, presence a second X male female conferred while its females blocked it. In hippocampal proteome mice, increased proteins involved synaptogenesis signaling – potential pathway cognition.
Influenza D virus (IDV) plays an important role in the bovine respiratory disease (BRD) complex. Its potential for zoonotic transmission is of particular concern. In China, IDV has previously been identified agricultural animals by molecular surveys with no live isolates reported. this study, IDVs were successfully isolated from cattle which prompted us to further investigate national prevalence, antigenic property, and infection biology virus. RNA was detected 11.1% (51/460) throughout...
Intramuscular fat (IMF) not only directly affects the tenderness, juiciness, and overall flavour of meat but also plays a significant role in influencing consumer preferences for pork. Therefore, exploring key biomarkers that influence IMF deposition is highly important breeding high-quality typical quantitative trait regulated by interaction multiple coding noncoding RNAs. Traditional differential analysis methods typically focus on individual genes, making it difficult to identify genes...
As an important type of noncoding RNA molecules, long non-coding RNAs (lncRNAs) act as versatile players in various biological processes. However, little is known about lncRNA regulators during sheep muscle growth. To explore functional lncRNAs growth, we systematically investigated using strand-specific Ribo-Zero sequencing at three key developmental stages Hu sheep. A total 6924 were obtained, and the differentially expressed genes screened from (control vs. experiment) fetus lamb, lamb...
Abstract Long non-coding RNAs (lncRNAs), >200 nt in length, are transcribed from mammalian genomes. They play important regulatory roles various biological processes; However, the function and expression profile of lncRNAs involved development hair follicles fetus, have been relatively under-explored area. To investigate specific role mRNAs that regulate follicle development, we herein performed a comprehensive study on lncRNA mRNA profiles sheep at multiple embryonic days (E65, E85,...