A5100782437- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- Wound Healing and Treatments
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Surgical Sutures and Adhesives
- RNA Interference and Gene Delivery
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Muscle Physiology and Disorders
- Nerve injury and regeneration
- Immune cells in cancer
- Total Knee Arthroplasty Outcomes
- Graphene and Nanomaterials Applications
Zhejiang University
2016-2025
Second Affiliated Hospital of Zhejiang University
2019-2025
Zhejiang University-University of Edinburgh Institute
2018-2025
Zhejiang Medicine (China)
2021-2023
Zhejiang International Studies University
2022
Hangzhou Red Cross Hospital
2016-2021
First Affiliated Hospital Zhejiang University
2018-2021
Guangxi Medical University
2019
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2015-2018
Shanghai Research Institute of Materials
2018
Abstract In this article, ultrafine gelatin (Gt) fibers were successfully produced with the use of electrical spinning or electrospinning technique. A fluorinated alcohol 2,2,2‐trifluoroethanol (TFE) was used as dissolving solvent. The morphology electrospun found to be dependent on alteration concentration ranging from 2.5% w/v 12.5% at increment intervals. Based obtained, 10% gelatin/TFE solution selected and mixed poly(ϵ‐caprolactone) (PCL) in TFE a ratio 50:50 co‐electrospun produce...
Uncontrollable bleeding is a major problem in surgical procedures and after trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial cardiac wounds because of their weak adhesion to wet mobile tissues. Here we design photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based hydrogel can undergo rapid gelling fixation adhere seal arteries walls UV light irradiation. These repairs withstand up 290 mm Hg blood...
Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have implicated in many diseases and known to participate physiological processes. Here, we investigate therapeutic potential exosomes from human embryonic cell-induced mesenchymal cells (ESC-MSCs) alleviating (OA).Exosomes were harvested conditioned culture media ESC-MSCs by a sequential centrifugation process....
Abstract Individual cells are basic units of life. Despite extensive efforts to characterize the cellular heterogeneity different organisms, cross-species comparisons landscape dynamics have not been achieved. Here, we applied single-cell RNA sequencing (scRNA-seq) map organism-level cell landscapes at multiple life stages for mice, zebrafish and Drosophila. By integrating comprehensive dataset > 2.6 million single cells, constructed a identified signatures common pathways that...
Cartilage damage has been documented as one of the major problems leading to knee repair procedures worldwide. The low availability cartilage that can be harvested without causing a negative health impact led focus on potential stem cells, which have transplanted into damaged areas and successfully grown new healthy tissue. This study aims compare chondrogenic two cell sources--adipose tissue bone marrow. Stem cells were isolated from donor-matched adipose marrow, following established...
Abstract One of the key problems hindering skin repair is deficiency dermal vascularization and difficulty epidermis regeneration, which makes it challenging to fabricate scaffolds that can biologically fulfill requirements for regeneration. To overcome this problem, three-dimensional printing was used a gelatin-sulfonated silk composite scaffold incorporated with basic fibroblast growth factor 2 (FGF-2) through binding sulfonic acid group (SO 3 ) (3DG-SF-SO -FGF). The efficacy mechanism by...
Tendon stem/progenitor cells (TSPCs) were recently identified within tendon tissues. The aim of this study was to investigate TSPC-seeded knitted silk—collagen sponge scaffold for functional shoulder repair. multidifferentiation potential, proliferation, and immune properties TSPCs investigated in vitro, while the efficacy scaffolds promoting rotator cuff regeneration evaluated vivo a rabbit model. TSPCs, which exhibited universal stem cell characteristics (i.e., clonogenicity, high...