A5100405116- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Heat shock proteins research
- Bioactive natural compounds
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Parasites and Host Interactions
- RNA Research and Splicing
- Plant biochemistry and biosynthesis
- Plant tissue culture and regeneration
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Biomarkers in Disease Mechanisms
- Alkaloids: synthesis and pharmacology
- Ziziphus Jujuba Studies and Applications
- Hormonal Regulation and Hypertension
- Plant Reproductive Biology
- NF-κB Signaling Pathways
- Wheat and Barley Genetics and Pathology
- Cancer, Lipids, and Metabolism
- Plant Gene Expression Analysis
- Ferroptosis and cancer prognosis
- Research on Leishmaniasis Studies
Yantai University
2024-2025
The University of Texas MD Anderson Cancer Center
2007-2025
Qingdao University
2023-2025
Affiliated Hospital of Qingdao University
2023-2025
Nanjing Forestry University
2022-2024
Eastern New Mexico University
2010-2024
Chosun University
2021-2024
Peking University People's Hospital
2018-2024
Peking University
2018-2024
Qilu Hospital of Shandong University
2016-2023
Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have implicated in many diseases and known to participate physiological processes. Here, we investigate therapeutic potential exosomes from human embryonic cell-induced mesenchymal cells (ESC-MSCs) alleviating (OA).Exosomes were harvested conditioned culture media ESC-MSCs by a sequential centrifugation process....
Deregulated miRNAs participate in osteosarcoma genesis. In this study, the expression of miRNA-218 human osteosarcomas, adjacent normal tissues and Saos-2 cells was first assessed. Then precise role investigated. Upon transfection with a miR-218 vector, proliferation determined using ATPlite assay significantly suppressed, whilw migration detected by wound healing invasion transwells were dramatically inhibited. Potential target genes predicted T-cell lymphoma metastasis 1 (TIAM1) matrix...
Abstract Progesterone resistance can significantly restrict the efficacy of conservative treatment for patients with endometrial cancer who wish to preserve their fertility or those suffer from advanced and recurrent cancer. SREBP1 is known be involved in occurrence progression cancer, although precise mechanism remains unclear. In present study, we carried out microarray analysis progesterone-sensitive progesterone-resistant cell lines demonstrated that related progesterone resistance....
Brain tumors almost universally have fatal outcomes; new therapeutics are desperately needed and will only come from improved understandins of glioma biology.Exosomes endosomally derived 30~100 nm membranous vesicles released many cell types. Examples GL26 cells were here purified using density gradient ultracentrifugation monitored for effects on tumor growth in C57BL/6j mice (H-2b). Lactate dehydrogenase release assays used to detect the cytotoxic activity CD8+T NK cells. Percentages...
Tung tree (Vernicia fordii) is an economically important widely cultivated for industrial oil production in China. To better understand the molecular basis of tung chloroplasts, we sequenced and characterized its genome using PacBio RS II sequencing platforms. The chloroplast was with 161,528 bp length, composed one pair inverted repeats (IRs) 26,819 bp, which were separated by small single copy (SSC; 18,758 bp) large (LSC; 89,132 bp). contains 114 genes, coding 81 protein, four ribosomal...
To seek new conservative treatments for young women with early-stage endometrial carcinoma (EC) who desire to retain fertility, we investigated the effects and underlying mechanism of silibinin in EC, which exhibits promising anti-cancer tumour-suppressing properties many malignant tumours.Through relevant experiments such as MTT assay, cell colony formation assay subcutaneous xenograft experiment, showed that inhibited proliferation EC cells tumours. Silibinin significantly induced cycle...
Progesterone resistance is a problem in endometrial carcinoma, and its underlying molecular mechanisms remain poorly understood. The aim of this study was to elucidate the progesterone identify key genes pathways mediating cancer using bioinformatics analysis. We developed stable MPA (medroxyprogesterone acetate)-resistant cell subline named IshikawaPR. Microarray analysis used differentially expressed (DEGs) from triplicate samples Ishikawa IshikawaPR cells. PANTHER, DAVID Metascape were...
Hydrangea macrophylla has a large inflorescence and rich colors, which made it one of the most popular ornamental flowers worldwide. Thus far, molecular mechanism flower color formation in H. is unknown. By comparing pigment content transcriptome data bud period (FSF1), discoloration (FSF2) full-bloom stage (FSF3) infertile blue cv. “Forever Summer,” we found that genes associated with anthocyanin production were throughout development. The biosynthesis pathway main metabolic formation,...
Abstract Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment progestin, and its underlying mechanisms remain unclear. YAP TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway, promote viability, metastasis also drug malignant tumors. According to our microarray analysis, YAP/TAZ were upregulated in progestin resistant IshikawaPR cell versus sensitive Ishikawa cell, which implied that may be vital promotor...
Inflammation has always been considered a trigger or consequence of neurodegenerative diseases, and the inhibition inflammation in central nervous system can effectively protect nerve cells. Several studies have indicated that various natural products inhibit neuroinflammation. Among these, Antarctic fungal metabolites pharmacological activities developmental value. Therefore, this study aimed to evaluate anti-neuroinflammatory activity an fungus belonging Aspergillus (strain SF-7367)....
Progesterone induces maturation of the amphibian oocyte through its action on plasma membrane. However, whether or not this requires high-affinity binding to a specific receptor is unclear. In study, activity progesterone was characterized in membranes from whole ovaries defolliculated oocytes Xenopus laevis. Membrane-bound, radiolabeled isolated by filtration membrane suspensions and quantified liquid scintillation. The association preparations reached equilibrium within 15 min. directly...
Article9 July 2020Open Access Source DataTransparent process Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction Gang Du Laboratory for Stem Cell and Anti-Aging Research, National Clinical Research Center Geriatrics, West China Hospital, Sichuan University, Chengdu, Key of Gene Engineering the Ministry Education, State Biocontrol, School Life Sciences, Sun Yat-sen Guangzhou, Search more papers this author Yicheng Qiao Zhangpeng Zhuo Jiaqi Zhou...
Pain is the most severe and common symptom of endometriosis. Its underlying pathogenetic mechanism poorly understood. Nerve sensitization a particular research challenge, due to limitations general endometriosis models sampling nerve tissue from patients. The chemokine fractalkine (FKN) has been demonstrated play key role in various forms neuropathic pain, while its endometriotic pain unknown. Our study was designed explore function FKN development maintenance peripheral hyperalgesia central...
Dove tree (Davidia involucrata Baill.) is a rare and endangered species. Natural reproduction of dove extremely difficult due to its low fecundity. Serious seed abortion one the key factors restraining sexual reproduction. Understanding inducements critical for addressing issue offspring production survivability such an However, studies on molecular mechanism in woody plants are lacking, dearth genomic resources restricts further research. In this study, using Illumina platform, we performed...
Abstract Asthma, an increasingly common chronic disease among children, are characterized by airway remodeling, which is partly attributed to the proliferation and migration of smooth muscle cell (ASMC). The purpose present study was investigate potential roles mechanisms tumor necrosis factor‐like weak inducer apoptosis (TWEAK)/fibroblast growth factor‐inducible molecule 14 (Fn14) axis on in HASMCs. Compared HASMCs from non‐asthmatic patients, those asthmatic patients showed elevated...