A5100615658- Diet and metabolism studies
- Dietary Effects on Health
- Mesenchymal stem cell research
- Salivary Gland Disorders and Functions
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Eating Disorders and Behaviors
- Traumatic Brain Injury and Neurovascular Disturbances
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Trauma and Emergency Care Studies
- Diabetes and associated disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV/AIDS drug development and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Tuberous Sclerosis Complex Research
- Emergency and Acute Care Studies
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Renal and related cancers
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
Zhejiang University
2014-2025
Second Affiliated Hospital of Zhejiang University
2021-2025
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Icahn School of Medicine at Mount Sinai
2023
Hangzhou Xixi hospital
2023
Craft Group (China)
2023
Henan Provincial People's Hospital
2023
Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have implicated in many diseases and known to participate physiological processes. Here, we investigate therapeutic potential exosomes from human embryonic cell-induced mesenchymal cells (ESC-MSCs) alleviating (OA).Exosomes were harvested conditioned culture media ESC-MSCs by a sequential centrifugation process....
Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These present a mixed glioneuronal phenotype have been hypothesized to originate from neural stem cells. However, this hypothesis has not tested empirically. Here, we report that loss of Tsc1 mouse subventricular zone (SVZ) stem/progenitor cells (NSPCs) results formation SEN- SEGA-like structural abnormalities the lateral ventricle,...
To describe the prevalence of coexisting conditions that affect clinical decision-making in adults with coronary heart disease (CHD).Cross-sectional.National Health and Nutrition Examination Survey, 1999 to 2004.Eight thousand six hundred fifty-four people aged 45 older; 1,259 CHD.Coexisting relevant implementing therapy for CHD across three domains: chronic diseases, self-reported laboratory-based measures, health status factors observed function. Prevalence was estimated according sex age,...
Abstract Mitochondria are vital organelles whose impairment leads to numerous metabolic disorders. Mitochondrial transplantation serves as a promising clinical therapy. However, its widespread application is hindered by the limited availability of healthy mitochondria, with dose required reaching up 10 9 mitochondria per injection/patient. This necessitates sustainable and tractable approaches for producing high-quality human mitochondria. In this study, we demonstrated highly efficient...
Tuberous sclerosis complex (TSC) is a genetic disorder linked to mutations of either the TSC1 or TSC2 gene, which encode proteins that form negatively regulate mammalian target rapamycin 1 (mTORC1). Clinically, small percentage TSC patients develop severe infantile polycystic kidney disease (PKD), believed be caused by deletion contiguous and PKD1 genes on human chromosome 16. Recent studies have implicated TSC/mTORC1 signaling pathway in PKD, but how dysfunction induces PKD not clear. We...
Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged and improve functional recovery in a rat model acute hemisected injury (SCI). The aim present study was determine whether BMSCs ASC promote SCI through regulation apoptosis immune responses. Whether this strategy regulates secondary inflammation, which is characterized by infiltration inflammatory mediators lesion site, repair...
Age-related increases in intermuscular adipose tissue (IMAT) impair muscle quality, decrease functional capacity, and promote several cardiometabolic inflammatory disorders. Whether these age-related alterations composition improve by consuming a high-protein (HP) diet with whole eggs are unclear. This parallel-design, randomized-controlled trial assessed the effects of 12-week eucaloric HP three per day (1.4 g protein kg−1 day−1) versus normal-protein void (NP, 0.8 on (IMAT), health,...
Abstract Bariatric surgery is the most effective treatment for severe obesity (body mass index >40), helping individuals lose, on average, 25%–29% of their body weight over first year. However, many patients begin to plateau and regain within 12–24 months, 20% 6 months postsurgery. As physical activity (PA) an important predictor loss maintenance postsurgery, there a need scalable, lifestyle interventions help bariatric increase PA in order maximize maintenance. To assess feasibility...
Abstract Stem cell transplantation represents a promising strategy for the repair of spinal cord injury ( SCI ). However, low survival rate grafted cells is major obstacle hindering clinical success because ongoing secondary processes, which includes excitotoxicity, inflammation and oxidative stress. Previous studies have shown that 17b‐estradiol (E2) protects several types against cytotoxicity. Thus, we examined effects E2 on viability human eyelid adipose‐derived stem (h EASC s) in vitro...
Articular cartilage injury and degeneration causing pain loss of quality-of-life has become a serious problem for increasingly aged populations. Given the poor self-renewal adult human chondrocytes, alternative functional cell sources are needed. Direct reprogramming by small molecules potentially offers an oncogene-free cost-effective approach to generate but yet be investigated. Here, we directly reprogrammed mouse embryonic fibroblasts into PRG4+ chondrocytes using 3D system with chemical...
Unhealthy Western-style eating patterns (WSEP) predominate, adversely affecting health. Resistance to improving dietary prompts interest incorporate a potentially health-promoting ingredient into typical WSEP foods and beverages. We assessed the effect of incorporating isocalorically matched carbohydrates versus milk protein isolate (MPI) on weight loss-induced changes in cardiometabolic health body composition. In randomized, double-blind, parallel-design study, 44 participants (age 52 ± 1...
Tenofovir disoproxil (TDF) is a promising salvage therapy for patients with chronic hepatitis B (CHB) who failed regimens of other nucleoside analogues (NAs). In this study, we aimed to investigate the clinical efficacy and safety TDF monotherapy in Chinese CHB genotypic resistance.A total 33 had treatment NAs resistance were switched 48 weeks. Patients' demographic data (age, sex, history virus [HBV] therapy), laboratory testing results (hepatitis e antigen [HBeAg] status, HBV DNA levels,...
Interleukin-22 (IL-22) affects epithelial tissue function and integrity in a context-dependent manner. IL-22 levels are elevated salivary glands of Sjögren's syndrome (SS) patients, but its role the pathogenesis this disease remains unclear. The objective study is to elucidate impact on gland murine models. We showed that sera increased progressively female non-obese diabetic (NOD) mice, accompanying development SS. Administration submandibular NOD mice prior onset reduced secretion induced...