A5101558121- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Nutrition and Health in Aging
- Frailty in Older Adults
- Osteoarthritis Treatment and Mechanisms
- Stoma care and complications
- Carbohydrate Chemistry and Synthesis
- Sphingolipid Metabolism and Signaling
- Mesenchymal stem cell research
- Cerebrovascular and genetic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
Zhejiang University
2015-2021
First Affiliated Hospital Zhejiang University
2021
Second Affiliated Hospital of Zhejiang University
2017-2019
Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising candidates have performed well in preclinical studies. Tumor necrosis factor α (TNFα) has been identified as a crucial effector modulating OA pathogenesis. This study aimed to investigate the therapeutic effects of Atsttrin, novel TNFα blocker, on treatment. We developed genetically modified mesenchymal stem cells (MSCs) that expressed...
It is well known that disruption of basal ganglia function generates the motor symptoms in PD, however, these are presented a heterogeneous manner; patients can be divided into tremor-dominant and akinesia/rigidity-dominant subtypes. To date, it unknown if differences could explained by on functional connectivity with specific brain regions. In this study, we aimed to explore alterations network-based global linking between PD-TD PD-AR patients. One hundred six PD 52 normal controls were...
Hemiparkinsonism duration in patients with Parkinson's disease (PD) is a key time window to study early pathology of PD. We aimed comprehensively explore the alterations deformation and structural network PD hemiparkinsonism, which could potentially disclose biomarker for Thirty-one hemiparkinsonism 37 age- gender- matched normal controls were included present study. First all, we normalized left hemisphere images as contralateral side affected limbs. Deformation-based morphometry (DBM) was...
Sarcopenia is one of the most frequent syndromes in older adults and its main characteristics low muscle mass. Gastrointestinal tumor a malignant disease with high incidence. This study aimed to investigate risk factors mass gastrointestinal tumor, prognostic indicators short-term outcomes after resection for explore relationship between postoperative prognosis.A total 247 patients tumors who underwent radical 2019 were included this study. Relevant indexes calculated using L3 slice image...